8SPD
Cytochrome P450 (CYP) 3A4 crystallized with clotrimazole
Summary for 8SPD
| Entry DOI | 10.2210/pdb8spd/pdb |
| Descriptor | Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, 1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE (3 entities in total) |
| Functional Keywords | inhibitor, complex, cyp, cytochrome p450, oxidoreductase |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 56555.96 |
| Authors | Hsu, M.H.,Johnson, E.F. (deposition date: 2023-05-02, release date: 2023-10-11, Last modification date: 2023-11-22) |
| Primary citation | Hsu, M.H.,Johnson, E.F. Differential Effects of Clotrimazole on X-Ray Crystal Structures of Human Cytochromes P450 3A5 and 3A4. Drug Metab.Dispos., 51:1642-1650, 2023 Cited by PubMed: 37770228DOI: 10.1124/dmd.123.001464 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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