7RL2

Crystal Structure of the Human Cytochrome P450 2C9*8 (CYP2C9*8) Genetic Variant in Complex with the Drug Losartan

Summary for 7RL2

• Entry DOI: 10.2210/pdb7rl2/pdb
• Descriptor: Cytochrome P450 2C9, PROTOPORPHYRIN IX CONTAINING FE, [2-butyl-5-chloranyl-3-[[4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol, ... (6 entities in total)
• Functional Keywords: cytochrome p450, cyp2c9, oxidoreductase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 55813.14

Authors

Shah, M.B. (deposition date: 2021-07-23, release date: 2021-10-06, Last modification date: 2023-10-18)

• Primary citation: Parikh, S.J.,Kamat, S.,Phillips, M.,Boyson, S.P.,Yarbrough, T.,Davie, D.,Zhang, Q.,Glass, K.C.,Shah, M.B.; Insights into the Genetic Variations of Human Cytochrome P450 2C9: Structural Analysis, Characterization and Comparison.; Int J Mol Sci, 22:-, 2021; PubMed: 34638547; DOI: 10.3390/ijms221910206

Experimental method

X-RAY DIFFRACTION (2.23 Å)