7RL2

Crystal Structure of the Human Cytochrome P450 2C9*8 (CYP2C9*8) Genetic Variant in Complex with the Drug Losartan

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Cytochrome P450 2C9	polymer	476	54216.8	1	UniProt (P11712) Pfam (PF00067) In PDB	Homo sapiens (Human)	(R)-limonene 6-monooxygenase,(S)-limonene 6-monooxygenase,(S)-limonene 7-monooxygenase,CYPIIC9,Cholesterol 25-hydroxylase,Cytochrome P-450MP,Cytochrome P450 MP-4,Cytochrome P450 MP-8,Cytochrome P450 PB-1,S-mephenytoin 4-hydroxylase
2	A	PROTOPORPHYRIN IX CONTAINING FE	non-polymer		616.5	1	Chemie (HEM)
3	A	[2-butyl-5-chloranyl-3-[[4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol	non-polymer		422.9	2	Chemie (LSN)
4	A	POTASSIUM ION	non-polymer		39.1	1	Chemie (K)
5	A	PHOSPHATE ION	non-polymer		95.0	1	Chemie (PO4)
6		water	water		18.0	125	Chemie (HOH)

Sequence modifications

A: 24 - 490 (UniProt: P11712)

PDB	External Database	Details
Met 19	-	initiating methionine
Ala 20	-	insertion
Lys 21	-	insertion
Lys 22	-	insertion
Thr 23	-	insertion
His 150	Arg 150	engineered mutation
Ile 490	Val 490	engineered mutation
His 491	-	expression tag
His 492	-	expression tag
His 493	-	expression tag
His 494	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	54216.8
Non-Polymers*	Number of molecules	5
	Total formula weight	1596.4
All*	Total formula weight	55813.1

*Water molecules are not included.