8SG5

Cytochrome P450 (CYP) 3A5 crystallized with clotrimazole

Summary for 8SG5

• Entry DOI: 10.2210/pdb8sg5/pdb
• Related: 8SPD
• Descriptor: Cytochrome P450 3A5, PROTOPORPHYRIN IX CONTAINING FE, 1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE, ... (4 entities in total)
• Functional Keywords: inhibitor, complex, cyp, cytochrome p450, oxidoreductase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 8
• Total formula weight: 456188.32

Authors

Hsu, M.H.,Johnson, E.F. (deposition date: 2023-04-11, release date: 2023-10-11, Last modification date: 2023-11-22)

• Primary citation: Hsu, M.H.,Johnson, E.F.; Differential Effects of Clotrimazole on X-Ray Crystal Structures of Human Cytochromes P450 3A5 and 3A4.; Drug Metab.Dispos., 51:1642-1650, 2023; PubMed: 37770228; DOI: 10.1124/dmd.123.001464

Experimental method

X-RAY DIFFRACTION (2.8 Å)