1EDY
 
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1AYO
 | | RECEPTOR BINDING DOMAIN OF BOVINE ALPHA-2-MACROGLOBULIN | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ALPHA-2-MACROGLOBULIN, CALCIUM ION | | 著者 | Jenner, L.B, Husted, L, Thirup, S, Sottrup-Jensen, L, Nyborg, J. | | 登録日 | 1997-11-07 | | 公開日 | 1998-11-25 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystal structure of the receptor-binding domain of alpha 2-macroglobulin.
Structure, 6, 1998
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1BV8
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4LNV
 | | Crystal Structure of TEP1s | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Thioester-containing protein I | | 著者 | Le, B.V, Williams, M, Logarajah, S, Baxter, R.H.G. | | 登録日 | 2013-07-12 | | 公開日 | 2013-07-24 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | | 主引用文献 | Molecular basis for genetic resistance of Anopheles gambiae to Plasmodium: structural analysis of TEP1 susceptible and resistant alleles.
Plos Pathog., 8, 2012
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8UH2
 | | Complex of C3b with the inhibitor albicin | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Albicin, Complement C3 beta chain, ... | | 著者 | Andersen, J.F, Lei, H, Strayer, E, Ribeiro, J.M. | | 登録日 | 2023-10-06 | | 公開日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (3.59 Å) | | 主引用文献 | The mechanism of a mosquito salivary inhibitor of the alternative C3 convertase is elucidated through structural analysis of its complex with C3bBb
To Be Published
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8UIN
 | | Structure of the C3bBb-albicin complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Albicin, ... | | 著者 | Andersen, J.F, Lei, H. | | 登録日 | 2023-10-10 | | 公開日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (3.86 Å) | | 主引用文献 | Mechanism of complement inhibition by a mosquito protein revealed through cryo-EM
To Be Published
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2A74
 | | Human Complement Component C3c | | 分子名称: | 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose, Complement Component C3c, GLYCEROL, ... | | 著者 | Janssen, B.J.C, Huizinga, E.G, Raaijmakers, H.C.A, Roos, A, Daha, M.R, Nilsson-Ekdahl, K, Nilsson, B, Gros, P. | | 登録日 | 2005-07-04 | | 公開日 | 2005-09-27 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structures of complement component C3 provide insights into the function and evolution of immunity.
Nature, 437, 2005
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2A73
 | | Human Complement Component C3 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3, alpha-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | 著者 | Janssen, B.J.C, Huizinga, E.G, Raaijmakers, H.C.A, Roos, A, Daha, M.R, Nilsson-Ekdahl, K, Nilsson, B, Gros, P. | | 登録日 | 2005-07-04 | | 公開日 | 2005-09-27 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Structures of complement component C3 provide insights into the function and evolution of immunity.
Nature, 437, 2005
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8ENU
 | | Structure of the C3bB proconvertase in complex with lufaxin | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3 beta chain, Complement C3b alpha' chain, ... | | 著者 | Andersen, J.F, Lei, H. | | 登録日 | 2022-09-30 | | 公開日 | 2023-08-09 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | | 主引用文献 | A bispecific inhibitor of complement and coagulation blocks activation in complementopathy models via a novel mechanism.
Blood, 141, 2023
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8EOK
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3T4A
 | | Structure of a truncated form of Staphylococcal Complement Inhibitor B bound to human C3c at 3.4 Angstrom resolution | | 分子名称: | Complement C3 beta chain, Complement C3c alpha' chain fragment 1, Complement C3c alpha' chain fragment 2, ... | | 著者 | Garcia, B.L, Geisbrecht, B.V, Summers, B.J. | | 登録日 | 2011-07-25 | | 公開日 | 2011-11-23 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Diversity in the C3b Convertase Contact Residues and Tertiary Structures of the Staphylococcal Complement Inhibitor (SCIN) Protein Family.
J.Biol.Chem., 287, 2012
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7TV9
 | | HUMAN COMPLEMENT COMPONENT C3B IN COMPLEX WITH APL-1030 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, APL-1030 Nanofitin, Complement C3 beta chain, ... | | 著者 | Fontano, E, Nadupalli, A, Lakshminarasimhan, D, White, A, Garlish, J, Cinier, M, Chevrel, A, Perrocheau, A, Eyerman, D, Orme, M, Kitten, O, Scheibler, L. | | 登録日 | 2022-02-04 | | 公開日 | 2022-03-30 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Discovery of APL-1030, a Novel, High-Affinity Nanofitin Inhibitor of C3-Mediated Complement Activation.
Biomolecules, 12, 2022
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5O35
 | | Structure of complement proteins complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3, Complement factor H,Complement factor H | | 著者 | Xue, X, Wu, J, Forneris, F, Gros, P. | | 登録日 | 2017-05-23 | | 公開日 | 2017-06-28 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (4.2 Å) | | 主引用文献 | Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses.
Nat. Struct. Mol. Biol., 24, 2017
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2PN5
 | | Crystal Structure of TEP1r | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SODIUM ION, ... | | 著者 | Baxter, R.H.G. | | 登録日 | 2007-04-23 | | 公開日 | 2007-07-24 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.698 Å) | | 主引用文献 | Structural basis for conserved complement factor-like function in the antimalarial protein TEP1
Proc.Natl.Acad.Sci.Usa, 104, 2007
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4D94
 | | Crystal Structure of TEP1r | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | | 著者 | Le, B.V, Williams, M, Logarajah, S, Baxter, R.H.G. | | 登録日 | 2012-01-11 | | 公開日 | 2012-10-17 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Molecular Basis for Genetic Resistance of Anopheles gambiae to Plasmodium: Structural Analysis of TEP1 Susceptible and Resistant Alleles.
Plos Pathog., 8, 2012
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8OQ3
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5O32
 | | The structure of complement complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Xue, X, Wu, J, Forneris, F, Gros, P. | | 登録日 | 2017-05-23 | | 公開日 | 2017-06-28 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (4.206209 Å) | | 主引用文献 | Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses.
Nat. Struct. Mol. Biol., 24, 2017
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8OVB
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2QKI
 | | Human C3c in complex with the inhibitor compstatin | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BROMIDE ION, Complement C3, ... | | 著者 | Janssen, B.J.C, Halff, E.F, Lambris, J.D, Gros, P. | | 登録日 | 2007-07-11 | | 公開日 | 2007-08-14 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structure of compstatin in complex with complement component C3c reveals a new mechanism of complement inhibition.
J.Biol.Chem., 282, 2007
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7VON
 | | Native alpha-2-macroglobulin monomer | | 分子名称: | Alpha-2-macroglobulin | | 著者 | Huang, X, Wang, Y. | | 登録日 | 2021-10-14 | | 公開日 | 2022-11-16 | | 最終更新日 | 2022-12-07 | | 実験手法 | ELECTRON MICROSCOPY (5.2 Å) | | 主引用文献 | Cryo-EM structures reveal the dynamic transformation of human alpha-2-macroglobulin working as a protease inhibitor.
Sci China Life Sci, 65, 2022
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4E0S
 | | Crystal Structure of C5b-6 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Complement C5, ... | | 著者 | Aleshin, A.E, Stec, B, DiScipio, R, Liddington, R.C. | | 登録日 | 2012-03-05 | | 公開日 | 2012-04-18 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (4.21 Å) | | 主引用文献 | Crystal structure of c5b-6 suggests structural basis for priming assembly of the membrane attack complex.
J.Biol.Chem., 287, 2012
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4A5W
 | | Crystal structure of C5b6 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, COMPLEMENT C5, ... | | 著者 | Hadders, M.A, Bubeck, D, Forneris, F, Pangburn, M, Llorca, O, Lea, S.M, Gros, P. | | 登録日 | 2011-10-28 | | 公開日 | 2012-03-14 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Assembly and Regulation of the Membrane Attack Complex Based on Structures of C5B6 and Sc5B9.
Cell Rep., 1, 2012
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6EHG
 | | complement component C3b in complex with a nanobody | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Jensen, R.K, Andersen, K.R, Gadeberg, T.A.F, Laursen, N.S, Andersen, G.R. | | 登録日 | 2017-09-13 | | 公開日 | 2018-02-14 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | A potent complement factor C3-specific nanobody inhibiting multiple functions in the alternative pathway of human and murine complement.
J. Biol. Chem., 293, 2018
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8COE
 | | complement C5 in complex with the LCP0195 nanobody | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C5 alpha chain, Complement C5 beta chain, ... | | 著者 | Andersen, G.R, Pedersen, D.V. | | 登録日 | 2023-02-28 | | 公開日 | 2024-01-03 | | 実験手法 | X-RAY DIFFRACTION (4.2 Å) | | 主引用文献 | Characterization of the bispecific VHH antibody gefurulimab (ALXN1720) targeting complement component 5, and designed for low volume subcutaneous administration.
Mol.Immunol., 165, 2023
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8CEM
 | | Structure of bovine native C3, re-refinement | | 分子名称: | Complement C3 alpha chain, Complement C3 beta chain, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | 著者 | Andersen, G.R, Fredslund, F. | | 登録日 | 2023-02-02 | | 公開日 | 2023-04-05 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | The structure of bovine complement component 3 reveals the basis for thioester function.
J Mol Biol, 361, 2006
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