9ESA
| |
6GR9
| Human AURKC INCENP complex bound to VX-680 | 分子名称: | Aurora kinase C, CYCLOPROPANECARBOXYLIC ACID {4-[4-(4-METHYL-PIPERAZIN-1-YL)-6-(5-METHYL-2H-PYRAZOL-3-YLAMINO)-PYRIMIDIN-2-YLSULFANYL]-PHENYL}-AMIDE, Inner centromere protein, ... | 著者 | Abdul Azeez, K.R, Sorrell, F.J, von Delft, F, Bountra, C, Knapp, S, Edwards, A.M, Arrowsmith, C, Elkins, J.M. | 登録日 | 2018-06-10 | 公開日 | 2019-05-15 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | AURKC INCENP complex bound to BRD-7880 To Be Published
|
|
6GR8
| Human AURKC INCENP complex bound to BRD-7880 | 分子名称: | 1-[(2~{R},3~{S})-2-[[1,3-benzodioxol-5-ylmethyl(methyl)amino]methyl]-3-methyl-6-oxidanylidene-5-[(2~{S})-1-oxidanylpropan-2-yl]-3,4-dihydro-2~{H}-1,5-benzoxazocin-8-yl]-3-(4-methoxyphenyl)urea, Aurora kinase C, Inner centromere protein | 著者 | Abdul Azeez, K.R, Sorrell, F.J, von Delft, F, Bountra, C, Knapp, S, Edwards, A.M, Arrowsmith, C, Elkins, J.M. | 登録日 | 2018-06-10 | 公開日 | 2019-05-15 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | AURKC INCENP complex bound to BRD-7880 To Be Published
|
|
5K3Y
| Crystal structure of AuroraB/INCENP in complex with BI 811283 | 分子名称: | Aurora kinase B-A, Inner centromere protein A, N-methyl-N-(1-methylpiperidin-4-yl)-4-{[4-({(1R,2S)-2-[(propan-2-yl)carbamoyl]cyclopentyl}amino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}benzamide | 著者 | Bader, G, Zahn, S.K, Zoephel, A. | 登録日 | 2016-05-20 | 公開日 | 2016-08-17 | 最終更新日 | 2022-12-07 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Pharmacological Profile of BI 847325, an Orally Bioavailable, ATP-Competitive Inhibitor of MEK and Aurora Kinases. Mol.Cancer Ther., 15, 2016
|
|
5EYK
| CRYSTAL STRUCTURE OF AURORA B IN COMPLEX WITH BI 847325 | 分子名称: | 3-[(3~{Z})-3-[[[4-[(dimethylamino)methyl]phenyl]amino]-phenyl-methylidene]-2-oxidanylidene-1~{H}-indol-6-yl]-~{N}-ethyl-prop-2-ynamide, Aurora kinase B-A, Inner centromere protein A | 著者 | Bader, G, Zoephel, A. | 登録日 | 2015-11-25 | 公開日 | 2016-08-17 | 最終更新日 | 2016-10-19 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Pharmacological Profile of BI 847325, an Orally Bioavailable, ATP-Competitive Inhibitor of MEK and Aurora Kinases. Mol.Cancer Ther., 15, 2016
|
|
4C2W
| Crystal structure of Aurora B in complex with AMP-PNP | 分子名称: | AURORA KINASE B-A, INNER CENTROMERE PROTEIN A, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | 著者 | Sessa, F, Villa, F. | 登録日 | 2013-08-20 | 公開日 | 2014-02-26 | 最終更新日 | 2014-03-19 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structure of Aurora B-Incenp in Complex with Barasertib Reveals a Potential Transinhibitory Mechanism Acta Crystallogr.,Sect.F, 70, 2014
|
|
4C2V
| Aurora B kinase in complex with the specific inhibitor Barasertib | 分子名称: | 2-[5-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]quinazolin-4-yl]amino]-1H-pyrazol-3-yl]-N-(3-fluorophenyl)ethanamide, AURORA KINASE B-A, INNER CENTROMERE PROTEIN A | 著者 | Sessa, F, Villa, F. | 登録日 | 2013-08-20 | 公開日 | 2014-02-26 | 最終更新日 | 2014-03-19 | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | 主引用文献 | Structure of Aurora B-Incenp in Complex with Barasertib Reveals a Potential Transinhibitory Mechanism Acta Crystallogr.,Sect.F, 70, 2014
|
|
4B8M
| Aurora B kinase in complex with VX-680 | 分子名称: | AURORA KINASE B-A, CYCLOPROPANECARBOXYLIC ACID {4-[4-(4-METHYL-PIPERAZIN-1-YL)-6-(5-METHYL-2H-PYRAZOL-3-YLAMINO)-PYRIMIDIN-2-YLSULFANYL]-PHENYL}-AMIDE, INNER CENTROMERE PROTEIN A | 著者 | Sessa, F, Villa, F. | 登録日 | 2012-08-28 | 公開日 | 2013-07-10 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structural and Biochemical Analysis of an Aurora B Kinase Mutant Reveals a Multistep Activation Mechanism To be Published
|
|
4B8L
| Aurora B kinase P353G mutant | 分子名称: | 9-{5-O-[(R)-hydroxy{[(R)-hydroxy(phosphonoamino)phosphoryl]oxy}phosphoryl]-alpha-L-arabinofuranosyl}-9H-purin-6-amine, AURORA KINASE B-A, INNER CENTROMERE PROTEIN A | 著者 | Sessa, F, Villa, F. | 登録日 | 2012-08-28 | 公開日 | 2013-07-10 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structural and Biochemical Analysis of an Aurora B Kinase Mutant Reveals a Multistep Activation Mechanism To be Published
|
|
4AF3
| Human Aurora B Kinase in complex with INCENP and VX-680 | 分子名称: | AURORA KINASE B, CYCLOPROPANECARBOXYLIC ACID {4-[4-(4-METHYL-PIPERAZIN-1-YL)-6-(5-METHYL-2H-PYRAZOL-3-YLAMINO)-PYRIMIDIN-2-YLSULFANYL]-PHENYL}-AMIDE, INNER CENTROMERE PROTEIN | 著者 | Elkins, J.M, Vollmar, M, Wang, J, Picaud, S, Arrowsmith, C.H, Edwards, A, Bountra, C, von Delft, F, Knapp, S. | 登録日 | 2012-01-16 | 公開日 | 2012-04-11 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Crystal Structure of Human Aurora B in Complex with Incenp and Vx-680. J.Med.Chem., 55, 2012
|
|
3ZTX
| Aurora kinase selective inhibitors identified using a Taxol-induced checkpoint sensitivity screen. | 分子名称: | 2-((4-(4-HYDROXYPIPERIDIN-1-YL)PHENYL)AMINO)-5,11-DIMETHYL-5H-BENZO[E]PYRIMIDO [5,4-B][1,4]DIAZEPIN-6(11H)-ONE, INNER CENTROMERE PROTEIN A, SERINE/THREONINE-PROTEIN KINASE 12-A | 著者 | Kwiatkowski, N, Villa, F, Musacchio, A, Gray, N. | 登録日 | 2011-07-12 | 公開日 | 2012-02-01 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Selective Aurora Kinase Inhibitors Identified Using a Taxol- Induced Checkpoint Sensitivity Screen. Acs Chem.Biol., 7, 2012
|
|
2VRX
| Structure of Aurora B kinase in complex with ZM447439 | 分子名称: | INNER CENTROMERE PROTEIN A, N-(4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinazolin-4-yl]amino}phenyl)benzamide, SERINE/THREONINE-PROTEIN KINASE 12-A | 著者 | Girdler, F, Sessa, F, Patercoli, S, Villa, F, Ridgway, E, Musacchio, A, Taylor, S.S. | 登録日 | 2008-04-16 | 公開日 | 2008-07-01 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Molecular Basis of Drug Resistance in Aurora Kinases. Chem.Biol., 15, 2008
|
|
2VGP
| Crystal structure of Aurora B kinase in complex with a aminothiazole inhibitor | 分子名称: | 4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-methylbenzamide, INNER CENTROMERE PROTEIN A, SERINE/THREONINE-PROTEIN KINASE 12-A | 著者 | Andersen, C.B, Wan, Y, Chang, J.W, Lee, C, Liu, Y, Sessa, F, Villa, F, Nallan, L, Musacchio, A, Gray, N.S. | 登録日 | 2007-11-15 | 公開日 | 2008-02-26 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Discovery of Selective Aminothiazole Aurora Kinase Inhibitors Acs Chem.Biol., 3, 2008
|
|
2VGO
| Crystal structure of Aurora B kinase in complex with Reversine inhibitor | 分子名称: | INNER CENTROMERE PROTEIN A, N~6~-cyclohexyl-N~2~-(4-morpholin-4-ylphenyl)-9H-purine-2,6-diamine, SERINE/THREONINE-PROTEIN KINASE 12-A | 著者 | D'Alise, A.M, Amabile, G, Iovino, M, Di Giorgio, F.P, Bartiromo, M, Sessa, F, Villa, F, Musacchio, A, Cortese, R. | 登録日 | 2007-11-15 | 公開日 | 2008-10-28 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Reversine, a Novel Aurora Kinases Inhibitor, Inhibits Colony Formation of Human Acute Myeloid Leukemia Cells. Mol.Cancer Ther., 7, 2008
|
|
2BFY
| Complex of Aurora-B with INCENP and Hesperadin. | 分子名称: | AURORA KINASE B-A, INNER CENTROMERE PROTEIN A, N-[2-OXO-3-((E)-PHENYL{[4-(PIPERIDIN-1-YLMETHYL)PHENYL]IMINO}METHYL)-2,6-DIHYDRO-1H-INDOL-5-YL]ETHANESULFONAMIDE | 著者 | Sessa, F, Mapelli, M, Ciferri, C, Tarricone, C, Areces, L.B, Schneider, T.R, Stukenberg, P.T, Musacchio, A. | 登録日 | 2004-12-15 | 公開日 | 2005-05-03 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Mechanism of Aurora B Activation by Incenp and Inhibition by Hesperadin Mol.Cell, 18, 2005
|
|
2BFX
| Mechanism of Aurora-B activation by INCENP and inhibition by Hesperadin. | 分子名称: | AURORA KINASE B-A, INNER CENTROMERE PROTEIN A | 著者 | Sessa, F, Mapelli, M, Ciferri, C, Tarricone, C, Areces, L.B, Schneider, T.R, Stukenberg, P.T, Musacchio, A. | 登録日 | 2004-12-15 | 公開日 | 2005-05-03 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Mechanism of Aurora B Activation by Incenp and Inhibition by Hesperadin Mol.Cell, 18, 2005
|
|