5K3Y

Crystal structure of AuroraB/INCENP in complex with BI 811283

Summary for 5K3Y

• Entry DOI: 10.2210/pdb5k3y/pdb
• Descriptor: Aurora kinase B-A, Inner centromere protein A, N-methyl-N-(1-methylpiperidin-4-yl)-4-{[4-({(1R,2S)-2-[(propan-2-yl)carbamoyl]cyclopentyl}amino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}benzamide, ... (4 entities in total)
• Functional Keywords: kinase, inhibitor, transferase
• Biological source: Xenopus laevis (African clawed frog); More
• Cellular location: Nucleus: Q6DE08 O13024
• Total number of polymer chains: 4
• Total formula weight: 81388.26

Authors

Bader, G.,Zahn, S.K.,Zoephel, A. (deposition date: 2016-05-20, release date: 2016-08-17, Last modification date: 2022-12-07)

• Primary citation: Sini, P.,Gurtler, U.,Zahn, S.K.,Baumann, C.,Rudolph, D.,Baumgartinger, R.,Strauss, E.,Haslinger, C.,Tontsch-Grunt, U.,Waizenegger, I.C.,Solca, F.,Bader, G.,Zoephel, A.,Treu, M.,Reiser, U.,Garin-Chesa, P.,Boehmelt, G.,Kraut, N.,Quant, J.,Adolf, G.R.; Pharmacological Profile of BI 847325, an Orally Bioavailable, ATP-Competitive Inhibitor of MEK and Aurora Kinases.; Mol.Cancer Ther., 15:2388-2398, 2016; PubMed: 27496137; DOI: 10.1158/1535-7163.MCT-16-0066

Experimental method

X-RAY DIFFRACTION (1.6 Å)