5K3Y

Crystal structure of AuroraB/INCENP in complex with BI 811283

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Aurora kinase B-A	polymer	280	33104.4	2	UniProt (Q6DE08) Pfam (PF00069) In PDB	Xenopus laevis (African clawed frog)	Aurora/IPL1-related kinase 2-A,AIRK2-A,XAIRK2-A,Serine/threonine-protein kinase 12-A,Serine/threonine-protein kinase aurora-B-A,xAurora-B
2	C, D	Inner centromere protein A	polymer	59	7028.1	2	UniProt (O13024) Pfam (PF03941) In PDB	Xenopus laevis (African clawed frog)	xIncenp,Mitotic phosphoprotein 130
3	A, B	N-methyl-N-(1-methylpiperidin-4-yl)-4-{[4-({(1R,2S)-2-[(propan-2-yl)carbamoyl]cyclopentyl}amino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}benzamide	non-polymer		561.6	2	Chemie (6Q4)
4		water	water		18.0	612	Chemie (HOH)

Sequence modifications

A, B: 78 - 356 (UniProt: Q6DE08)

PDB	External Database	Details
Gly 77	-	expression tag
Val 96	Gly 96	conflict

C, D: 790 - 847 (UniProt: O13024)

PDB	External Database	Details
Met 789	-	initiating methionine

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	80265.0
Non-Polymers*	Number of molecules	2
	Total formula weight	1123.3
All*	Total formula weight	81388.3

*Water molecules are not included.