4AF3
Human Aurora B Kinase in complex with INCENP and VX-680
Summary for 4AF3
Entry DOI | 10.2210/pdb4af3/pdb |
Descriptor | AURORA KINASE B, INNER CENTROMERE PROTEIN, CYCLOPROPANECARBOXYLIC ACID {4-[4-(4-METHYL-PIPERAZIN-1-YL)-6-(5-METHYL-2H-PYRAZOL-3-YLAMINO)-PYRIMIDIN-2-YLSULFANYL]-PHENYL}-AMIDE, ... (4 entities in total) |
Functional Keywords | transferase-inhibitor complex, aurkb, transferase/inhibitor |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Nucleus: Q96GD4 Q9NQS7 |
Total number of polymer chains | 2 |
Total formula weight | 42400.17 |
Authors | Elkins, J.M.,Vollmar, M.,Wang, J.,Picaud, S.,Arrowsmith, C.H.,Edwards, A.,Bountra, C.,von Delft, F.,Knapp, S. (deposition date: 2012-01-16, release date: 2012-04-11, Last modification date: 2023-12-20) |
Primary citation | Elkins, J.M.,Santaguida, S.,Musacchio, A.,Knapp, S. Crystal Structure of Human Aurora B in Complex with Incenp and Vx-680. J.Med.Chem., 55:7841-, 2012 Cited by PubMed: 22920039DOI: 10.1021/JM3008954 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.75 Å) |
Structure validation
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