4AF3
Human Aurora B Kinase in complex with INCENP and VX-680
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | AURORA KINASE B | polymer | 292 | 33706.1 | 1 | UniProt (Q96GD4) Pfam (PF00069) In PDB | HOMO SAPIENS (HUMAN) | AURORA 1, AURORA B, AURORA- AND IPL1-LIKE MIDBODY-ASSOCIATED PROTEIN 1, AIM-1, AURORA/IPL1-RELATED KINASE 2, ARK-2, AURORA-RELATED KINASE 2, STK-1, SERINE/THREONINE 12 -PROTEIN KINASE SERINE/THREONINE-PROTEIN KINASE 5, SERINE/THREONINE-PROTEIN KINASE AURORA-B |
| 2 | D | INNER CENTROMERE PROTEIN | polymer | 71 | 8229.5 | 1 | UniProt (Q9NQS7) Pfam (PF03941) In PDB | HOMO SAPIENS (HUMAN) | INCENP |
| 3 | A | CYCLOPROPANECARBOXYLIC ACID {4-[4-(4-METHYL-PIPERAZIN-1-YL)-6-(5-METHYL-2H-PYRAZOL-3-YLAMINO)-PYRIMIDIN-2-YLSULFANYL]-PHENYL}-AMIDE | non-polymer | 464.6 | 1 | Chemie (VX6) | |||
| 4 | water | water | 18.0 | 31 | Chemie (HOH) |
Sequence modifications
A: 55 - 344 (UniProt: Q96GD4)
D: 835 - 903 (UniProt: Q9NQS7)
| PDB | External Database | Details |
|---|---|---|
| Ser 53 | - | expression tag |
| Met 54 | - | expression tag |
| Thr 298 | Met 298 | variant |
| PDB | External Database | Details |
|---|---|---|
| Ser 833 | - | expression tag |
| Met 834 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 41935.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 464.6 | |
| All* | Total formula weight | 42400.2 |
