4AF3

Human Aurora B Kinase in complex with INCENP and VX-680

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE VX6 A 500

Chain	Residue
A	LEU83
A	LEU207
A	HOH2015
A	PHE88
A	ALA104
A	LYS106
A	GLU155
A	TYR156
A	ALA157
A	PRO158
A	GLY160

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Functional Information from PROSITE/UniProt

site_id	PS00092
Number of Residues	7
Details	N6_MTASE N-6 Adenine-specific DNA methylases signature. LVGNPPF

Chain	Residue	Details
A	LEU267-PHE273

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site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGKFGNVYlArekkshfi..........VALK

Chain	Residue	Details
A	LEU83-LYS106

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site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ViHrDIKpeNLLL

Chain	Residue	Details
A	VAL196-LEU208

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by AURKB and AURKC => ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:27332895

Chain	Residue	Details
D	THR892

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine; by AURKB and AURKC => ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:27332895

Chain	Residue	Details
D	SER893
A	LYS106

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine; by AURKB and AURKC => ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:27332895, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163

Chain	Residue	Details
D	SER894

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
D	SER899

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:26829474

Chain	Residue	Details
A	LYS215

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site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER227

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site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:14722118, ECO:0000269|PubMed:26829474

Chain	Residue	Details
A	THR232

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