PDB: 75 件ウェブページステータス検索Chemie searchBIRD

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7P37	Streptomyces coelicolor ATP-loaded NrdR 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Transcriptional repressor NrdR, ZINC ION 著者 Martinez-Carranza, M, Stenmark, P. 登録日 2021-07-07 公開日 2022-05-11 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (2.96 Å) 主引用文献 A nucleotide-sensing oligomerization mechanism that controls NrdR-dependent transcription of ribonucleotide reductases. Nat Commun, 13, 2022
7P3Q	Streptomyces coelicolor dATP/ATP-loaded NrdR octamer 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Transcriptional repressor NrdR, ... 著者 Martinez-Carranza, M, Stenmark, P. 登録日 2021-07-08 公開日 2022-05-11 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (3.12 Å) 主引用文献 A nucleotide-sensing oligomerization mechanism that controls NrdR-dependent transcription of ribonucleotide reductases. Nat Commun, 13, 2022
7P3F	Streptomyces coelicolor dATP/ATP-loaded NrdR in complex with its cognate DNA 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, DNA (50-MER), ... 著者 Martinez-Carranza, M, Stenmark, P. 登録日 2021-07-07 公開日 2022-05-11 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (3.31 Å) 主引用文献 A nucleotide-sensing oligomerization mechanism that controls NrdR-dependent transcription of ribonucleotide reductases. Nat Commun, 13, 2022
8P23	Cryo-EM structure of the anaerobic ribonucleotide reductase from Prevotella copri in its dimeric, ATP/CTP-bound state 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Anaerobic ribonucleoside-triphosphate reductase, CYTIDINE-5'-TRIPHOSPHATE, ... 著者 Banerjee, I, Bimai, O, Sjoberg, B.M, Logan, D.T. 登録日 2023-05-14 公開日 2023-08-30 最終更新日 2024-09-25 実験手法 ELECTRON MICROSCOPY (3.17 Å) 主引用文献 Nucleotide binding to the ATP-cone in anaerobic ribonucleotide reductases allosterically regulates activity by modulating substrate binding. Elife, 12, 2024
8P28	Cryo-EM structure of the anaerobic ribonucleotide reductase from Prevotella copri in its tetrameric, dATP-bound state 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Anaerobic ribonucleoside-triphosphate reductase, MAGNESIUM ION 著者 Banerjee, I, Bimai, O, Sjoberg, B.M, Logan, D.T. 登録日 2023-05-15 公開日 2023-08-30 最終更新日 2024-09-25 実験手法 ELECTRON MICROSCOPY (2.77 Å) 主引用文献 Nucleotide binding to the ATP-cone in anaerobic ribonucleotide reductases allosterically regulates activity by modulating substrate binding. Elife, 12, 2024
8P27	Cryo-EM structure of the anaerobic ribonucleotide reductase from Prevotella copri in its dimeric, dATP-bound state 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Anaerobic ribonucleoside-triphosphate reductase, MAGNESIUM ION 著者 Banerjee, I, Bimai, O, Sjoberg, B.M, Logan, D.T. 登録日 2023-05-15 公開日 2023-08-30 最終更新日 2024-09-25 実験手法 ELECTRON MICROSCOPY (2.73 Å) 主引用文献 Nucleotide binding to the ATP-cone in anaerobic ribonucleotide reductases allosterically regulates activity by modulating substrate binding. Elife, 12, 2024
8P2C	Cryo-EM structure of the anaerobic ribonucleotide reductase from Prevotella copri in its tetrameric state produced in the presence of dATP and CTP 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Anaerobic ribonucleoside-triphosphate reductase, MAGNESIUM ION 著者 Banerjee, I, Bimai, O, Sjoberg, B.M, Logan, D.T. 登録日 2023-05-15 公開日 2023-09-13 最終更新日 2024-09-25 実験手法 ELECTRON MICROSCOPY (2.59 Å) 主引用文献 Nucleotide binding to the ATP-cone in anaerobic ribonucleotide reductases allosterically regulates activity by modulating substrate binding. Elife, 12, 2024
8P2S	Cryo-EM structure of the anaerobic ribonucleotide reductase from Prevotella copri in its dimeric, ATP/dTTP/GTP-bound state 分子名称: Anaerobic ribonucleoside-triphosphate reductase, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Bimai, O, Banerjee, I, Sjoberg, B.M, Logan, D.T. 登録日 2023-05-16 公開日 2023-09-13 最終更新日 2024-09-25 実験手法 ELECTRON MICROSCOPY (2.4 Å) 主引用文献 Nucleotide binding to the ATP-cone in anaerobic ribonucleotide reductases allosterically regulates activity by modulating substrate binding. Elife, 12, 2024
8P39	Cryo-EM structure of the anaerobic ribonucleotide reductase from Prevotella copri in its dimeric, dGTP/ATP-bound state 分子名称: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Anaerobic ribonucleoside-triphosphate reductase, ... 著者 Bimai, O, Banerjee, I, Sjoberg, B.M, Logan, D.T. 登録日 2023-05-17 公開日 2023-09-13 最終更新日 2024-09-25 実験手法 ELECTRON MICROSCOPY (2.58 Å) 主引用文献 Nucleotide binding to the ATP-cone in anaerobic ribonucleotide reductases allosterically regulates activity by modulating substrate binding. Elife, 12, 2024
8P2D	Cryo-EM structure of the dimeric form of the anaerobic ribonucleotide reductase from Prevotella copri produced in the presence of dATP and CTP 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Anaerobic ribonucleoside-triphosphate reductase, MAGNESIUM ION 著者 Banerjee, I, Bimai, O, Sjoberg, B.M, Logan, D.T. 登録日 2023-05-15 公開日 2023-09-13 最終更新日 2024-09-25 実験手法 ELECTRON MICROSCOPY (2.59 Å) 主引用文献 Nucleotide binding to the ATP-cone in anaerobic ribonucleotide reductases allosterically regulates activity by modulating substrate binding. Elife, 12, 2024
5D1Y	Low resolution crystal structure of human ribonucleotide reductase alpha6 hexamer in complex with dATP 分子名称: Ribonucleoside-diphosphate reductase large subunit 著者 Ando, N, Li, H, Brignole, E.J, Thompson, S, McLaughlin, M.I, Page, J, Asturias, F, Stubbe, J, Drennan, C.L. 登録日 2015-08-04 公開日 2016-01-20 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (9.005 Å) 主引用文献 Allosteric Inhibition of Human Ribonucleotide Reductase by dATP Entails the Stabilization of a Hexamer. Biochemistry, 55, 2016
5OLK	Crystal structure of the ATP-cone-containing NrdB from Leeuwenhoekiella blandensis 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, MAGNESIUM ION, ... 著者 Hasan, M, Grinberg, A.R, Sjoberg, B.M, Logan, D.T. 登録日 2017-07-28 公開日 2018-01-10 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Novel ATP-cone-driven allosteric regulation of ribonucleotide reductase via the radical-generating subunit. Elife, 7, 2018
3UUS	Crystal structure of the dATP inhibited E. coli class Ia ribonucleotide reductase complex 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, FE (III) ION, Ribonucleoside-diphosphate reductase 1 subunit alpha, ... 著者 Zimanyi, C.M, Drennan, C.L. 登録日 2011-11-28 公開日 2011-12-21 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (5.65 Å) 主引用文献 Structural interconversions modulate activity of Escherichia coli ribonucleotide reductase. Proc.Natl.Acad.Sci.USA, 108, 2011
5IM3	Crystal structure of the class I ribonucleotide reductase from Pseudomonas aeruginosa in complex with dATP 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase 著者 Johansson, R, Logan, D.T. 登録日 2016-03-05 公開日 2016-05-04 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (2.298 Å) 主引用文献 Structural Mechanism of Allosteric Activity Regulation in a Ribonucleotide Reductase with Double ATP Cones. Structure, 24, 2016
7MDI	Structure of the Neisseria gonorrhoeae ribonucleotide reductase in the inactive state 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CYTIDINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Levitz, T.S, Drennan, C.L, Brignole, E.J. 登録日 2021-04-05 公開日 2022-01-05 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (4.3 Å) 主引用文献 Effects of chameleon dispense-to-plunge speed on particle concentration, complex formation, and final resolution: A case study using the Neisseria gonorrhoeae ribonucleotide reductase inactive complex. J.Struct.Biol., 214, 2021
7R1R	RIBONUCLEOTIDE REDUCTASE E441Q MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 分子名称: RIBONUCLEOTIDE REDUCTASE R1 PROTEIN, RIBONUCLEOTIDE REDUCTASE R2 PROTEIN 著者 Eriksson, M, Eklund, H. 登録日 1997-09-17 公開日 1998-03-18 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 A new mechanism-based radical intermediate in a mutant R1 protein affecting the catalytically essential Glu441 in Escherichia coli ribonucleotide reductase. J.Biol.Chem., 272, 1997
4R1R	RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH SUBSTRATE, GDP AND EFFECTOR DTTP FROM ESCHERICHIA COLI 分子名称: GUANOSINE-5'-DIPHOSPHATE, RIBONUCLEOTIDE REDUCTASE R1 PROTEIN, RIBONUCLEOTIDE REDUCTASE R2 PROTEIN, ... 著者 Eriksson, M, Eklund, H. 登録日 1997-07-22 公開日 1998-01-28 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Binding of allosteric effectors to ribonucleotide reductase protein R1: reduction of active-site cysteines promotes substrate binding. Structure, 5, 1997
3PAW	Low resolution X-ray crystal structure of Yeast Rnr1p with dATP bound in the A-site 分子名称: Ribonucleoside-diphosphate reductase large chain 1 著者 Fairman, J.W, Wijerathna, S.R, Dealwis, C.G. 登録日 2010-10-19 公開日 2011-02-23 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (6.61 Å) 主引用文献 Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization. Nat.Struct.Mol.Biol., 18, 2011
4X3V	Crystal structure of human ribonucleotide reductase 1 bound to inhibitor 分子名称: N~6~-{N-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetyl]-2-methyl-D-alanyl}-D-lysine, Ribonucleoside-diphosphate reductase large subunit, THYMIDINE-5'-TRIPHOSPHATE 著者 Dealwis, C.G, Ahmad, M.F, Alam, I. 登録日 2014-12-01 公開日 2015-11-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.7 Å) 主引用文献 Identification of Non-nucleoside Human Ribonucleotide Reductase Modulators. J.Med.Chem., 58, 2015
6R1R	RIBONUCLEOTIDE REDUCTASE E441D MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 分子名称: RIBONUCLEOTIDE REDUCTASE R1 PROTEIN, RIBONUCLEOTIDE REDUCTASE R2 PROTEIN 著者 Eriksson, M, Eklund, H. 登録日 1997-09-17 公開日 1998-03-18 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 A new mechanism-based radical intermediate in a mutant R1 protein affecting the catalytically essential Glu441 in Escherichia coli ribonucleotide reductase. J.Biol.Chem., 272, 1997
7AGJ	Ribonucleotide Reductase R1 protein from Aquifex aeolicus 分子名称: ADENOSINE-5'-TRIPHOSPHATE, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... 著者 Rehling, D, Scaletti, E.R, Stenmark, P. 登録日 2020-09-22 公開日 2021-10-06 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural and Biochemical Investigation of Class I Ribonucleotide Reductase from the Hyperthermophile Aquifex aeolicus. Biochemistry, 61, 2022
6W4X	Holocomplex of E. coli class Ia ribonucleotide reductase with GDP and TTP 分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, MU-OXO-DIIRON, ... 著者 Kang, G, Taguchi, A, Stubbe, J, Drennan, C.L. 登録日 2020-03-11 公開日 2020-04-08 最終更新日 2024-09-25 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structure of a trapped radical transfer pathway within a ribonucleotide reductase holocomplex. Science, 368, 2020
6AUI	Human ribonucleotide reductase large subunit (alpha) with dATP and CDP 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CYTIDINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Brignole, E.J, Drennan, C.L, Asturias, F.J, Tsai, K.L, Penczek, P.A. 登録日 2017-09-01 公開日 2018-04-18 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 3.3- angstrom resolution cryo-EM structure of human ribonucleotide reductase with substrate and allosteric regulators bound. Elife, 7, 2018
2R1R	RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH DTTP OCCUPYING THE SPECIFICITY SITE FROM ESCHERICHIA COLI 分子名称: RIBONUCLEOTIDE REDUCTASE R1 PROTEIN, RIBONUCLEOTIDE REDUCTASE R2 PROTEIN, THYMIDINE-5'-TRIPHOSPHATE 著者 Eriksson, M, Eklund, H. 登録日 1997-07-21 公開日 1998-01-28 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Binding of allosteric effectors to ribonucleotide reductase protein R1: reduction of active-site cysteines promotes substrate binding. Structure, 5, 1997
5R1R	RIBONUCLEOTIDE REDUCTASE E441A MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 分子名称: RIBONUCLEOTIDE REDUCTASE R1 PROTEIN, RIBONUCLEOTIDE REDUCTASE R2 PROTEIN 著者 Eriksson, M, Eklund, H. 登録日 1997-09-17 公開日 1998-03-18 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 A new mechanism-based radical intermediate in a mutant R1 protein affecting the catalytically essential Glu441 in Escherichia coli ribonucleotide reductase. J.Biol.Chem., 272, 1997

 

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