1P42
| Crystal structure of Aquifex aeolicus LpxC Deacetylase (Zinc-Inhibited Form) | 分子名称: | MYRISTIC ACID, UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION | 著者 | Whittington, D.A, Rusche, K.M, Shin, H, Fierke, C.A, Christianson, D.W. | 登録日 | 2003-04-21 | 公開日 | 2003-06-10 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal Structure of LpxC, a Zinc-Dependent Deacetylase Essential for Endotoxin Biosynthesis Proc.Natl.Acad.Sci.USA, 100, 2003
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1XXE
| RDC refined solution structure of the AaLpxC/TU-514 complex | 分子名称: | 1,5-ANHYDRO-2-C-(CARBOXYMETHYL-N-HYDROXYAMIDE)-2-DEOXY-3-O-MYRISTOYL-D-GLUCITOL, UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION | 著者 | Coggins, B.E, McClerren, A.L, Jiang, L, Li, X, Rudolph, J, Hindsgaul, O, Raetz, C.R.H, Zhou, P. | 登録日 | 2004-11-04 | 公開日 | 2004-11-23 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Refined Solution Structure of the LpxC-TU-514 Complex and pK(a) Analysis of an Active Site Histidine: Insights into the Mechanism and Inhibitor Design Biochemistry, 44, 2005
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1YH8
| Crystal structure of Aquifex aeolicus LpxC deacetylase complexed with palmitate | 分子名称: | CHLORIDE ION, PALMITOLEIC ACID, UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ... | 著者 | Hernick, M, Gennadios, H.A, Whittington, D.A, Rusche, K.M, Christianson, D.W, Fierke, C.A. | 登録日 | 2005-01-07 | 公開日 | 2005-02-15 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine Deacetylase Functions through a General Acid-Base Catalyst Pair Mechanism J.Biol.Chem., 280, 2005
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1YHC
| Crystal structure of Aquifex aeolicus LpxC deacetylase complexed with cacodylate | 分子名称: | CACODYLATE ION, CHLORIDE ION, GLYCEROL, ... | 著者 | Hernick, M, Gennadios, H.A, Whittington, D.A, Rusche, K.M, Christianson, D.W, Fierke, C.A. | 登録日 | 2005-01-07 | 公開日 | 2005-02-15 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine Deacetylase Functions through a General Acid-Base Catalyst Pair Mechanism J.Biol.Chem., 280, 2005
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2GO3
| Crystal structure of Aquifex aeolicus LpxC complexed with imidazole. | 分子名称: | CHLORIDE ION, GLYCEROL, IMIDAZOLE, ... | 著者 | Gennadios, H.A, Whittington, D.A, Li, X, Fierke, C.A, Christianson, D.W. | 登録日 | 2006-04-12 | 公開日 | 2006-07-04 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Mechanistic Inferences from the Binding of Ligands to LpxC, a Metal-Dependent Deacetylase Biochemistry, 45, 2006
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2GO4
| Crystal structure of Aquifex aeolicus LpxC complexed with TU-514 | 分子名称: | 1,5-ANHYDRO-2-C-(CARBOXYMETHYL-N-HYDROXYAMIDE)-2-DEOXY-3-O-MYRISTOYL-D-GLUCITOL, CHLORIDE ION, UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ... | 著者 | Gennadios, H.A, Whittington, D.A, Li, X, Fierke, C.A, Christianson, D.W. | 登録日 | 2006-04-12 | 公開日 | 2006-07-04 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Mechanistic Inferences from the Binding of Ligands to LpxC, a Metal-Dependent Deacetylase Biochemistry, 45, 2006
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2IER
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2IES
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2J65
| Structure of LpxC from Aquifex aeolicus in complex with UDP | 分子名称: | CHLORIDE ION, MYRISTIC ACID, UDP-3-O-[3-HYDROXYMYRISTOYL] N-ACETYLGLUCOSAMINE DEACETYLASE, ... | 著者 | Buetow, L, Dawson, A, Hunter, W.N. | 登録日 | 2006-09-26 | 公開日 | 2006-11-08 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The Nucleotide-Binding Site of Aquifex Aeolicus Lpxc. Acta Crystallogr.,Sect.F, 62, 2006
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2JT2
| Solution Structure of the Aquifex aeolicus LpxC- CHIR-090 complex | 分子名称: | N-{(1S,2R)-2-hydroxy-1-[(hydroxyamino)carbonyl]propyl}-4-{[4-(morpholin-4-ylmethyl)phenyl]ethynyl}benzamide, UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION | 著者 | Barb, A.W, Jiang, L, Raetz, C.R.H, Zhou, P. | 登録日 | 2007-07-18 | 公開日 | 2007-12-04 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding Proc.Natl.Acad.Sci.Usa, 104, 2007
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2O3Z
| X-ray crystal structure of LpxC complexed with 3-heptyloxybenzoate | 分子名称: | 3-(heptyloxy)benzoic acid, CHLORIDE ION, SULFATE ION, ... | 著者 | Gennadios, H.A, Whittington, D.A, Christianson, D.W. | 登録日 | 2006-12-02 | 公開日 | 2007-02-27 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Amphipathic benzoic acid derivatives: synthesis and binding in the hydrophobic tunnel of the zinc deacetylase LpxC. Bioorg.Med.Chem., 15, 2007
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2VES
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3NZK
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3P3C
| Crystal Structure of the Aquifex aeolicus LpxC/LPC-009 complex | 分子名称: | N-[(1S,2R)-2-hydroxy-1-(hydroxycarbamoyl)propyl]-4-(4-phenylbuta-1,3-diyn-1-yl)benzamide, PHOSPHATE ION, UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ... | 著者 | Lee, C.-J, Zhou, P. | 登録日 | 2010-10-04 | 公開日 | 2011-01-05 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Species-specific and inhibitor-dependent conformations of LpxC: implications for antibiotic design. Chem.Biol., 18, 2011
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3P3E
| Crystal Structure of the PSEUDOMONAS AERUGINOSA LpxC/LPC-009 complex | 分子名称: | N-[(1S,2R)-2-hydroxy-1-(hydroxycarbamoyl)propyl]-4-(4-phenylbuta-1,3-diyn-1-yl)benzamide, NITRATE ION, SODIUM ION, ... | 著者 | Lee, C.-J, Zhou, P. | 登録日 | 2010-10-04 | 公開日 | 2011-01-05 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.28 Å) | 主引用文献 | Species-specific and inhibitor-dependent conformations of LpxC: implications for antibiotic design. Chem.Biol., 18, 2011
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3P76
| X-ray crystal structure of Aquifex aeolicus LpxC complexed SCH1379777 | 分子名称: | IMIDAZOLE, N-[(1S,2R)-2-hydroxy-1-(hydroxycarbamoyl)propyl]-4-[4-(phenylethynyl)phenyl]piperidine-1-carboxamide, UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ... | 著者 | Orth, P. | 登録日 | 2010-10-12 | 公開日 | 2011-02-09 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Design and synthesis of potent Gram-negative specific LpxC inhibitors. Bioorg.Med.Chem.Lett., 21, 2011
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3U1Y
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3UHM
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4FW3
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4FW4
| Crystal Structure of the LpxC in complex with N-[(1S,2R)-2-HYDROXY-1-(HYDROXYCARBAMOYL)PROPYL]-4-(4-PHENYLBUTA-1,3-DIYN-1-YL)BENZAMIDE inhibitor | 分子名称: | ACETATE ION, GLYCEROL, N-[(1S,2R)-2-hydroxy-1-(hydroxycarbamoyl)propyl]-4-(4-phenylbuta-1,3-diyn-1-yl)benzamide, ... | 著者 | Kang, Y.N, Stuckey, J.A. | 登録日 | 2012-06-29 | 公開日 | 2013-05-15 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | Crystal Structure of the LpxC to be published
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4FW5
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4FW6
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4FW7
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4J3D
| Pseudomonas aeruginosa LpxC in complex with a hydroxamate inhibitor | 分子名称: | N~1~-hydroxy-N~5~-(3-hydroxypropyl)-N~2~-[4-(phenylethynyl)benzoyl]-L-glutamamide, UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION | 著者 | Lahiri, S. | 登録日 | 2013-02-05 | 公開日 | 2013-04-03 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Exploring the UDP pocket of LpxC through amino acid analogs. Bioorg.Med.Chem.Lett., 23, 2013
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4LCF
| Crystal structure of the Pseudomonas aeruginosa LPXC/LPC-014 complex | 分子名称: | NITRATE ION, Nalpha-{4-[4-(4-aminophenyl)buta-1,3-diyn-1-yl]benzoyl}-N-hydroxy-L-histidinamide, UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ... | 著者 | Lee, C.-J, Zhou, P. | 登録日 | 2013-06-21 | 公開日 | 2013-08-21 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.599 Å) | 主引用文献 | Synthesis, Structure, and Antibiotic Activity of Aryl-Substituted LpxC Inhibitors. J.Med.Chem., 56, 2013
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