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3U1Y

Potent Inhibitors of LpxC for the Treatment of Gram-Negative Infections

Summary for 3U1Y
Entry DOI10.2210/pdb3u1y/pdb
DescriptorUDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION, (2R)-N-hydroxy-2-methyl-2-(methylsulfonyl)-4-{4'-[3-(morpholin-4-yl)propoxy]biphenyl-4-yl}butanamide, ... (4 entities in total)
Functional Keywordspseudomonas aeruginosa, lpxc, gram negative, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourcePseudomonas aeruginosa
Total number of polymer chains2
Total formula weight67470.68
Authors
Brown, M.,Abramite, J.,Liu, S. (deposition date: 2011-09-30, release date: 2012-01-04, Last modification date: 2023-09-13)
Primary citationBrown, M.F.,Reilly, U.,Abramite, J.A.,Arcari, J.T.,Oliver, R.,Barham, R.A.,Che, Y.,Chen, J.M.,Collantes, E.M.,Chung, S.W.,Desbonnet, C.,Doty, J.,Doroski, M.,Engtrakul, J.J.,Harris, T.M.,Huband, M.,Knafels, J.D.,Leach, K.L.,Liu, S.,Marfat, A.,Marra, A.,McElroy, E.,Melnick, M.,Menard, C.A.,Montgomery, J.I.,Mullins, L.,Noe, M.C.,O'Donnell, J.,Penzien, J.,Plummer, M.S.,Price, L.M.,Shanmugasundaram, V.,Thoma, C.,Uccello, D.P.,Warmus, J.S.,Wishka, D.G.
Potent inhibitors of LpxC for the treatment of Gram-negative infections.
J.Med.Chem., 55:914-923, 2012
Cited by
PubMed: 22175825
DOI: 10.1021/jm2014748
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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