3U1Y
Potent Inhibitors of LpxC for the Treatment of Gram-Negative Infections
Summary for 3U1Y
Entry DOI | 10.2210/pdb3u1y/pdb |
Descriptor | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION, (2R)-N-hydroxy-2-methyl-2-(methylsulfonyl)-4-{4'-[3-(morpholin-4-yl)propoxy]biphenyl-4-yl}butanamide, ... (4 entities in total) |
Functional Keywords | pseudomonas aeruginosa, lpxc, gram negative, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Pseudomonas aeruginosa |
Total number of polymer chains | 2 |
Total formula weight | 67470.68 |
Authors | Brown, M.,Abramite, J.,Liu, S. (deposition date: 2011-09-30, release date: 2012-01-04, Last modification date: 2023-09-13) |
Primary citation | Brown, M.F.,Reilly, U.,Abramite, J.A.,Arcari, J.T.,Oliver, R.,Barham, R.A.,Che, Y.,Chen, J.M.,Collantes, E.M.,Chung, S.W.,Desbonnet, C.,Doty, J.,Doroski, M.,Engtrakul, J.J.,Harris, T.M.,Huband, M.,Knafels, J.D.,Leach, K.L.,Liu, S.,Marfat, A.,Marra, A.,McElroy, E.,Melnick, M.,Menard, C.A.,Montgomery, J.I.,Mullins, L.,Noe, M.C.,O'Donnell, J.,Penzien, J.,Plummer, M.S.,Price, L.M.,Shanmugasundaram, V.,Thoma, C.,Uccello, D.P.,Warmus, J.S.,Wishka, D.G. Potent inhibitors of LpxC for the treatment of Gram-negative infections. J.Med.Chem., 55:914-923, 2012 Cited by PubMed: 22175825DOI: 10.1021/jm2014748 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
Download full validation report