3U1Y
Potent Inhibitors of LpxC for the Treatment of Gram-Negative Infections
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase | polymer | 299 | 33146.6 | 2 | UniProt (P47205) Pfam (PF03331) | Pseudomonas aeruginosa | Protein envA, UDP-3-O-acyl-GlcNAc deacetylase |
| 2 | C, E, G (A, B) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 3 | D, F (A, B) | (2R)-N-hydroxy-2-methyl-2-(methylsulfonyl)-4-{4'-[3-(morpholin-4-yl)propoxy]biphenyl-4-yl}butanamide | non-polymer | 490.6 | 2 | Chemie (03I) | |||
| 4 | H, I (A, B) | water | water | 18.0 | 312 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 299 (UniProt: P47205)
| PDB | External Database | Details |
|---|---|---|
| Ser 40 | Cys 40 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 66293.2 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1177.5 | |
| All* | Total formula weight | 67470.7 |
