3NZK

Structure of LpxC from Yersinia enterocolitica Complexed with CHIR090 Inhibitor

Summary for 3NZK

• Entry DOI: 10.2210/pdb3nzk/pdb
• Descriptor: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, N-{(1S,2R)-2-hydroxy-1-[(hydroxyamino)carbonyl]propyl}-4-{[4-(morpholin-4-ylmethyl)phenyl]ethynyl}benzamide, ZINC ION, ... (5 entities in total)
• Functional Keywords: deacetylase, endotoxin, metal-binding, hydrolase
• Biological source: Yersinia enterocolitica
• Total number of polymer chains: 2
• Total formula weight: 70903.72

Authors

Cole, K.E.,Christianson, D.W. (deposition date: 2010-07-16, release date: 2011-01-05, Last modification date: 2023-09-06)

• Primary citation: Cole, K.E.,Gattis, S.G.,Angell, H.D.,Fierke, C.A.,Christianson, D.W.; Structure of the Metal-Dependent Deacetylase LpxC from Yersinia enterocolitica Complexed with the Potent Inhibitor CHIR-090 .; Biochemistry, 50:258-262, 2010; PubMed: 21171638; DOI: 10.1021/bi101622a

Experimental method

X-RAY DIFFRACTION (1.8 Å)