2VES

Crystal Structure of LpxC from Pseudomonas aeruginosa complexed with the potent BB-78485 inhibitor

Summary for 2VES

Entry DOI	10.2210/pdb2ves/pdb
Descriptor	UDP-3-O-acyl-N-acetylglucosamine deacetylase, ZINC ION, (2R)-N-hydroxy-3-naphthalen-2-yl-2-[(naphthalen-2-ylsulfonyl)amino]propanamide, ... (5 entities in total)
Functional Keywords	lpxc, hydrolase, bb-78485, antibiotics, deacetylase, lipid synthesis, metalloprotease, hydroxamic acid, gram-negative bacteria, lipopolysaccharide, lipid a biosynthesis
Biological source	Pseudomonas aeruginosa
Total number of polymer chains	3
Total formula weight	101351.28
Authors	Mochalkin, I.,Knafels, J.D. (deposition date: 2007-10-26, release date: 2008-01-15, Last modification date: 2023-12-13)
Primary citation	Mochalkin, I.,Knafels, J.D.,Lightle, S. Crystal structure of LpxC from Pseudomonas aeruginosa complexed with the potent BB-78485 inhibitor. Protein Sci., 17:450-457, 2008 Cited by PubMed: 18287278 DOI: 10.1110/ps.073324108 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation