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4J3D

Pseudomonas aeruginosa LpxC in complex with a hydroxamate inhibitor

Summary for 4J3D
Entry DOI10.2210/pdb4j3d/pdb
DescriptorUDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION, N~1~-hydroxy-N~5~-(3-hydroxypropyl)-N~2~-[4-(phenylethynyl)benzoyl]-L-glutamamide, ... (4 entities in total)
Functional Keywordslpxc, metalloamidase, udp-3-o-(r-3-hydroxymyristoyl)-n-acetylglucosamine deacetylase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourcePseudomonas aeruginosa
Total number of polymer chains2
Total formula weight66925.30
Authors
Lahiri, S. (deposition date: 2013-02-05, release date: 2013-04-03, Last modification date: 2024-02-28)
Primary citationHale, M.R.,Hill, P.,Lahiri, S.,Miller, M.D.,Ross, P.,Alm, R.,Gao, N.,Kutschke, A.,Johnstone, M.,Prince, B.,Thresher, J.,Yang, W.
Exploring the UDP pocket of LpxC through amino acid analogs.
Bioorg.Med.Chem.Lett., 23:2362-2367, 2013
Cited by
PubMed: 23499237
DOI: 10.1016/j.bmcl.2013.02.055
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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