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8VRN
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Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus PPTQ
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(4-methylphenyl)-2-phenylquinazolin-4(3H)-one, ...
著者Chojnacka, W, Teng, J, Kim, J.J, Jensen, A.A, Hibbs, R.E.
登録日2024-01-22
公開日2024-06-26
最終更新日2024-07-03
実験手法ELECTRON MICROSCOPY (2.57 Å)
主引用文献Structural insights into GABA A receptor potentiation by Quaalude.
Nat Commun, 15, 2024
8VQY
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Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus methaqualone
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-methyl-3-(2-methylphenyl)quinazolin-4(3H)-one, GAMMA-AMINO-BUTANOIC ACID, ...
著者Chojnacka, W, Teng, J, Kim, J.J, Jensen, A.A, Hibbs, R.E.
登録日2024-01-19
公開日2024-06-26
最終更新日2024-07-03
実験手法ELECTRON MICROSCOPY (2.82 Å)
主引用文献Structural insights into GABA A receptor potentiation by Quaalude.
Nat Commun, 15, 2024
8V8C
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Alpha7-nicotinic acetylcholine receptor time resolved bound to epibatidine and PNU-120596 asymmetric state 1
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Burke, S.M, Noviello, C.M, Hibbs, R.E.
登録日2023-12-05
公開日2024-02-21
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (3.29 Å)
主引用文献Structural mechanisms of alpha 7 nicotinic receptor allosteric modulation and activation.
Cell, 187, 2024
8V88
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Alpha7-nicotinic acetylcholine receptor bound to epibatidine and GAT107
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, (3aR,4S,9bS)-4-(4-bromophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide, (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, ...
著者Burke, S.M, Noviello, C.M, Hibbs, R.E.
登録日2023-12-05
公開日2024-02-21
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (2.3 Å)
主引用文献Structural mechanisms of alpha 7 nicotinic receptor allosteric modulation and activation.
Cell, 187, 2024
8V8D
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Alpha7-nicotinic acetylcholine receptor time resolved bound to epibatidine and PNU-120596 asymmetric state 2
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Burke, S.M, Noviello, C.M, Hibbs, R.E.
登録日2023-12-05
公開日2024-02-21
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (3.31 Å)
主引用文献Structural mechanisms of alpha 7 nicotinic receptor allosteric modulation and activation.
Cell, 187, 2024
8V8A
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Alpha7-nicotinic acetylcholine receptor time resolved bound to epibatidine and PNU-120596 desensitized intermediate state
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Burke, S.M, Noviello, C.M, Hibbs, R.E.
登録日2023-12-05
公開日2024-02-21
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (2.19 Å)
主引用文献Structural mechanisms of alpha 7 nicotinic receptor allosteric modulation and activation.
Cell, 187, 2024
8V89
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Alpha7-nicotinic acetylcholine receptor time resolved resting state
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Burke, S.M, Noviello, C.M, Hibbs, R.E.
登録日2023-12-05
公開日2024-02-21
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (2.53 Å)
主引用文献Structural mechanisms of alpha 7 nicotinic receptor allosteric modulation and activation.
Cell, 187, 2024
8V82
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BU of 8v82 by Molmil
Alpha7-nicotinic acetylcholine receptor bound to epibatidine and PNU-120596
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Burke, S.M, Noviello, C.M, Hibbs, R.E.
登録日2023-12-04
公開日2024-02-21
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (2.61 Å)
主引用文献Structural mechanisms of alpha 7 nicotinic receptor allosteric modulation and activation.
Cell, 187, 2024
8V86
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Alpha7-nicotinic acetylcholine receptor bound to GAT107
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, (3aR,4S,9bS)-4-(4-bromophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide, (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, ...
著者Burke, S.M, Noviello, C.M, Hibbs, R.E.
登録日2023-12-04
公開日2024-02-21
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (2.47 Å)
主引用文献Structural mechanisms of alpha 7 nicotinic receptor allosteric modulation and activation.
Cell, 187, 2024
8V80
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BU of 8v80 by Molmil
Alpha7-nicotinic acetylcholine receptor bound to epibatidine and (-)-TQS
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, (3aR,4S,9bS)-4-(naphthalen-1-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide, (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, ...
著者Burke, S.M, Noviello, C.M, Hibbs, R.E.
登録日2023-12-04
公開日2024-02-21
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (2.34 Å)
主引用文献Structural mechanisms of alpha 7 nicotinic receptor allosteric modulation and activation.
Cell, 187, 2024
8UZJ
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BU of 8uzj by Molmil
Alpha7-nicotinic acetylcholine receptor bound to epibatidine and ivermectin
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside, (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, ...
著者Burke, S.M, Noviello, C.M, Hibbs, R.E.
登録日2023-11-15
公開日2024-02-21
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (2.3 Å)
主引用文献Structural mechanisms of alpha 7 nicotinic receptor allosteric modulation and activation.
Cell, 187, 2024
8UTB
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Alpha7-nicotinic acetylcholine receptor bound to epibatidine and NS-1738
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Burke, S.M, Noviello, C.M, Hibbs, R.E.
登録日2023-10-30
公開日2024-02-21
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (2.3 Å)
主引用文献Structural mechanisms of alpha 7 nicotinic receptor allosteric modulation and activation.
Cell, 187, 2024
8UT1
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BU of 8ut1 by Molmil
Alpha7-nicotinic acetylcholine receptor bound to epibatidine
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Burke, S.M, Hibbs, R.E, Noviello, C.M.
登録日2023-10-30
公開日2024-02-21
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (2.3 Å)
主引用文献Structural mechanisms of alpha 7 nicotinic receptor allosteric modulation and activation.
Cell, 187, 2024
8QQM
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BU of 8qqm by Molmil
nicotinic acetylcholine receptor in intact synaptic membrane
分子名称: Acetylcholine receptor subunit alpha, Acetylcholine receptor subunit beta, Acetylcholine receptor subunit delta, ...
著者Unwin, N.
登録日2023-10-05
公開日2024-05-08
実験手法ELECTRON MICROSCOPY (4.7 Å)
主引用文献Influence of lipid bilayer on the structure of the muscle-type nicotinic acetylcholine receptor.
Proc.Natl.Acad.Sci.USA, 121, 2024
8PVB
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BU of 8pvb by Molmil
Structure of GABAAR determined by cryoEM at 100 keV
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, DECANE, ...
著者McMullan, G, Naydenova, K, Mihaylov, D, Peet, M.J, Wilson, H, Yamashita, K, Dickerson, J.L, Chen, S, Cannone, G, Lee, Y, Hutchings, K.A, Gittins, O, Sobhy, M, Wells, T, El-Gomati, M.M, Dalby, J, Meffert, M, Schulze-Briese, C, Henderson, R, Russo, C.J.
登録日2023-07-17
公開日2023-11-29
最終更新日2024-01-31
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Structure determination by cryoEM at 100 keV.
Proc.Natl.Acad.Sci.USA, 120, 2023
8ST0
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BU of 8st0 by Molmil
The 2alpha3beta stoichiometry of full-length human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYLCHOLINE, IgG1 Heavy Chain, ...
著者Kang, G, Hibbs, R.E.
登録日2023-05-09
公開日2024-02-07
実験手法ELECTRON MICROSCOPY (2.4 Å)
主引用文献Structure of the 2alpha3beta stoichiometry of the full-length human alpha4beta2 nicotinic receptor in complex with acetylcholine
To Be Published
8ST1
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The 3alpha2beta stoichiometry of human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine and calcium
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYLCHOLINE, CALCIUM ION, ...
著者Kang, G, Hibbs, R.E.
登録日2023-05-09
公開日2024-02-07
実験手法ELECTRON MICROSCOPY (3.41 Å)
主引用文献Structure of the 3alpha2beta stoichiometry of the human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine and calcium
To Be Published
8ST2
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The 3alpha2beta stoichiometry of human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYLCHOLINE, IgG1 Heavy Chain, ...
著者Kang, G, Hibbs, R.E.
登録日2023-05-09
公開日2024-02-07
実験手法ELECTRON MICROSCOPY (2.94 Å)
主引用文献Structure of the 3alpha2beta stoichiometry of the human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine
To Be Published
8ST4
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BU of 8st4 by Molmil
The 2alpha3beta stoichiometry of human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYLCHOLINE, IgG1 Heavy Chain, ...
著者Kang, G, Hibbs, R.E.
登録日2023-05-09
公開日2024-02-07
実験手法ELECTRON MICROSCOPY (2.35 Å)
主引用文献Structure of the 2alpha3beta stoichiometry of the human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine
To Be Published
8SSZ
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BU of 8ssz by Molmil
The 2alpha3beta stoichiometry of full-length human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine and calcium
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYLCHOLINE, CALCIUM ION, ...
著者Kang, G, Hibbs, R.E.
登録日2023-05-09
公開日2024-02-07
実験手法ELECTRON MICROSCOPY (2.64 Å)
主引用文献Structure of the 2alpha3beta stoichiometry of the full-length human alpha4beta2 nicotinic receptor in complex with acetylcholine and calcium
To Be Published
8ST3
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BU of 8st3 by Molmil
The 2alpha3beta stoichiometry of human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine and calcium
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYLCHOLINE, CALCIUM ION, ...
著者Kang, G, Hibbs, R.E.
登録日2023-05-09
公開日2024-02-07
実験手法ELECTRON MICROSCOPY (2.93 Å)
主引用文献Structure of the 2alpha3beta stoichiometry of the human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine and calcium
To Be Published
8SID
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BU of 8sid by Molmil
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus dehydroepiandrosterone sulfate
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 17-oxoandrost-5-en-3beta-yl hydrogen sulfate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Legesse, D.H, Hibbs, R.E.
登録日2023-04-14
公開日2023-08-30
最終更新日2023-11-15
実験手法ELECTRON MICROSCOPY (2.71 Å)
主引用文献Structural insights into opposing actions of neurosteroids on GABA A receptors.
Nat Commun, 14, 2023
8SI9
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BU of 8si9 by Molmil
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus allopregnanolone
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, ...
著者Legesse, D.H, Hibbs, R.E.
登録日2023-04-14
公開日2023-08-30
最終更新日2023-11-15
実験手法ELECTRON MICROSCOPY (2.98 Å)
主引用文献Structural insights into opposing actions of neurosteroids on GABA A receptors.
Nat Commun, 14, 2023
8SGO
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BU of 8sgo by Molmil
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus pregnenolone sulfate
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, ...
著者Legesse, D.H, Fan, C, Teng, J, Zhuang, Y, Howard, R.J, Noviello, C.M, Lindahl, E, Hibbs, R.E.
登録日2023-04-12
公開日2023-08-30
最終更新日2023-11-15
実験手法ELECTRON MICROSCOPY (2.65 Å)
主引用文献Structural insights into opposing actions of neurosteroids on GABA A receptors.
Nat Commun, 14, 2023
8OQ6
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CryoEM structure of human rho1 GABAA receptor apo state
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, DECANE, ...
著者Chen, F, Victor, T, John, C, Rebecca, J.H, Lindahl, E.
登録日2023-04-11
公開日2023-08-30
最終更新日2024-02-07
実験手法ELECTRON MICROSCOPY (3.21 Å)
主引用文献Structure and dynamics of differential ligand binding in the human rho-type GABA A receptor.
Neuron, 111, 2023

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件を2024-07-10に公開中

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