8BJS
 
 | | Apo KIF20A[55-510] crystal structure | | 分子名称: | Kinesin-like protein KIF20A, SULFATE ION, UNK-UNK-UNK-UNK | | 著者 | Ranaivoson, F.M, Kikuti, C, Crozet, V, Sirkia, M.E, Houdusse, A. | | 登録日 | 2022-11-06 | | 公開日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.73 Å) | | 主引用文献 | Nucleotide-free structures of KIF20A illuminate atypical mechanochemistry in this kinesin-6.
Open Biology, 13, 2023
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4Y05
 | | KIF2C short Loop2 construct | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF2C, MAGNESIUM ION, ... | | 著者 | Wang, W, Knossow, M, Gigant, B. | | 登録日 | 2015-02-05 | | 公開日 | 2015-06-17 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | | 主引用文献 | New Insights into the Coupling between Microtubule Depolymerization and ATP Hydrolysis by Kinesin-13 Protein Kif2C.
J.Biol.Chem., 290, 2015
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8YHH
 | | The Crystal Structure of Mitotic Kinesin Eg5 from Biortus | | 分子名称: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ADENOSINE-5'-DIPHOSPHATE, ... | | 著者 | Wang, F, Cheng, W, Lv, Z, Qi, J, Wu, B. | | 登録日 | 2024-02-28 | | 公開日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | The Crystal Structure of Mitotic Kinesin Eg5 from Biortus
To Be Published
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1F9V
 | | CRYSTAL STRUCTURES OF MUTANTS REVEAL A SIGNALLING PATHWAY FOR ACTIVATION OF THE KINESIN MOTOR ATPASE | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KAR3, MAGNESIUM ION | | 著者 | Yun, M, Zhang, X, Park, C.G, Park, H.W, Endow, S.A. | | 登録日 | 2000-07-11 | | 公開日 | 2001-06-13 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | A structural pathway for activation of the kinesin motor ATPase.
EMBO J., 20, 2001
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5X3E
 | | kinesin 6 | | 分子名称: | IODIDE ION, Kinesin-like protein, SULFATE ION | | 著者 | Chen, Z, Guan, R, Zhang, L. | | 登録日 | 2017-02-04 | | 公開日 | 2017-04-19 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | | 主引用文献 | Crystal structure of Zen4 in the apo state reveals a missing conformation of kinesin
Nat Commun, 8, 2017
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4OZQ
 | | Crystal structure of the mouse Kif14 motor domain | | 分子名称: | 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, Chimera of Maltose-binding periplasmic protein and Kinesin family member 14 protein | | 著者 | Arora, K, Talje, L, Asenjo, A.B, Andersen, P, Atchia, K, Joshi, M, Sosa, H, Kwok, B.H, Allingham, J.S. | | 登録日 | 2014-02-18 | | 公開日 | 2014-07-09 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.71 Å) | | 主引用文献 | KIF14 binds tightly to microtubules and adopts a rigor-like conformation.
J.Mol.Biol., 426, 2014
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2G1Q
 | | crystal structure of KSP in complex with inhibitor 9h | | 分子名称: | (5S)-5-(3-AMINOPROPYL)-3-(2,5-DIFLUOROPHENYL)-N-ETHYL-5-PHENYL-4,5-DIHYDRO-1H-PYRAZOLE-1-CARBOXAMIDE, ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF11, ... | | 著者 | Yan, Y. | | 登録日 | 2006-02-14 | | 公開日 | 2006-10-03 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | | 主引用文献 | Kinesin spindle protein (KSP) inhibitors. Part 4: Structure-based design of 5-alkylamino-3,5-diaryl-4,5-dihydropyrazoles as potent, water-soluble inhibitors of the mitotic kinesin KSP.
Bioorg.Med.Chem.Lett., 16, 2006
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6Y1I
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3L9H
 | | X-ray structure of mitotic kinesin-5 (KSP, KIF11, Eg5)in complex with the hexahydro-2H-pyrano[3,2-c]quinoline EMD 534085 | | 分子名称: | 1-[2-(dimethylamino)ethyl]-3-{[(2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl]methyl}urea, ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF11 | | 著者 | Knoechel, T. | | 登録日 | 2010-01-05 | | 公開日 | 2010-03-02 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The discovery and optimization of hexahydro-2H-pyrano[3,2-c]quinolines (HHPQs) as potent and selective inhibitors of the mitotic kinesin-5.
Bioorg.Med.Chem.Lett., 20, 2010
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1X88
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1CZ7
 | | THE CRYSTAL STRUCTURE OF A MINUS-END DIRECTED MICROTUBULE MOTOR PROTEIN NCD REVEALS VARIABLE DIMER CONFORMATIONS | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, MICROTUBULE MOTOR PROTEIN NCD | | 著者 | Kozielski, F.K, De Bonis, S, Burmeister, W, Cohen-Addad, C, Wade, R. | | 登録日 | 1999-09-01 | | 公開日 | 1999-11-05 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | The crystal structure of the minus-end-directed microtubule motor protein ncd reveals variable dimer conformations.
Structure Fold.Des., 7, 1999
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4UBF
 | | HsMCAK motor domain complex | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF2C, MAGNESIUM ION | | 著者 | Welburn, J.P.I, Talapatra, S.K. | | 登録日 | 2014-08-12 | | 公開日 | 2015-05-06 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | The C-terminal region of the motor protein MCAK controls its structure and activity through a conformational switch.
Elife, 4, 2015
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4ZCA
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6G6Z
 | | Eg5-inhibitor complex | | 分子名称: | (~{N}~{Z})-~{N}-[(5~{S})-4-ethanoyl-5-methyl-5-phenyl-1,3,4-thiadiazolidin-2-ylidene]ethanamide, ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF11, ... | | 著者 | Talapatra, S.K, Kozielski, F, Tham, C.L. | | 登録日 | 2018-04-04 | | 公開日 | 2018-08-08 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Crystal structure of the Eg5 - K858 complex and implications for structure-based design of thiadiazole-containing inhibitors.
Eur J Med Chem, 156, 2018
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6HKX
 | | Eg5-inhibitor complex | | 分子名称: | (2~{S})-2-(3-azanylpropyl)-5-[2,5-bis(fluoranyl)phenyl]-~{N}-methoxy-~{N}-methyl-2-phenyl-1,3,4-thiadiazole-3-carboxamide, ADENOSINE-5'-DIPHOSPHATE, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Talapatra, S.K, Kozielski, F. | | 登録日 | 2018-09-09 | | 公開日 | 2019-09-25 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Is the Fate of Clinical Candidate Arry-520 Already Sealed? Predicting Resistance in Eg5-Inhibitor Complexes.
Mol.Cancer Ther., 18, 2019
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6HKY
 | | Eg5-inhibitor complex | | 分子名称: | (2~{S})-2-(3-azanylpropyl)-5-[2,5-bis(fluoranyl)phenyl]-~{N}-methoxy-~{N}-methyl-2-phenyl-1,3,4-thiadiazole-3-carboxamide, ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF11, ... | | 著者 | Talapatra, S.K, Kozielski, F. | | 登録日 | 2018-09-09 | | 公開日 | 2019-09-25 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Is the Fate of Clinical Candidate Arry-520 Already Sealed? Predicting Resistance in Eg5-Inhibitor Complexes.
Mol.Cancer Ther., 18, 2019
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1BG2
 | | HUMAN UBIQUITOUS KINESIN MOTOR DOMAIN | | 分子名称: | ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, KINESIN, ... | | 著者 | Kull, F.J, Sablin, E.P, Lau, R, Fletterick, R.J, Vale, R.D. | | 登録日 | 1998-06-04 | | 公開日 | 1998-10-14 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal structure of the kinesin motor domain reveals a structural similarity to myosin.
Nature, 380, 1996
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1N6M
 | | Rotation of the stalk/neck and one head in a new crystal structure of the kinesin motor protein, Ncd | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Claret segregational protein, MAGNESIUM ION | | 著者 | Yun, M, Bronner, C.E, Park, C.-G, Cha, S.-S, Park, H.-W, Endow, S.A. | | 登録日 | 2002-11-11 | | 公開日 | 2003-10-28 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Rotation of the stalk/neck and one head in a new crystal structure of the kinesin motor protein, Ncd
EMBO J., 22, 2003
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3NWN
 | | Crystal structure of the human KIF9 motor domain in complex with ADP | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, Kinesin-like protein KIF9, ... | | 著者 | Zhu, H, Tempel, W, He, H, Shen, Y, Wang, J, Brothers, G, Landry, R, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | | 登録日 | 2010-07-09 | | 公開日 | 2010-07-21 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structure of the human KIF9 motor domain in complex with ADP
To be Published
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1YRS
 | | Crystal structure of KSP in complex with inhibitor 1 | | 分子名称: | 3-[(5S)-1-ACETYL-3-(2-CHLOROPHENYL)-4,5-DIHYDRO-1H-PYRAZOL-5-YL]PHENOL, ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF11, ... | | 著者 | Cox, C.D, Breslin, M.J, Mariano, B.J, Coleman, P.J, Buser, C.A, Walsh, E.S, Hamilton, K, Kohl, N.E, Torrent, M, Yan, Y, Kuo, L.C, Hartman, G.D. | | 登録日 | 2005-02-04 | | 公開日 | 2005-04-12 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP
BIOORG.MED.CHEM.LETT., 15, 2005
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6G6Y
 | | Eg5-inhibitor complex | | 分子名称: | (~{N}~{Z})-~{N}-[(5~{S})-4-ethanoyl-5-methyl-5-phenyl-1,3,4-thiadiazolidin-2-ylidene]ethanamide, ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF11, ... | | 著者 | Talapatra, S.K, Kozielski, F, Tham, C.L. | | 登録日 | 2018-04-03 | | 公開日 | 2018-08-08 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal structure of the Eg5 - K858 complex and implications for structure-based design of thiadiazole-containing inhibitors.
Eur J Med Chem, 156, 2018
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4ZHI
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1Q0B
 | | Crystal structure of the motor protein KSP in complex with ADP and monastrol | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ETHYL 4-(3-HYDROXYPHENYL)-6-METHYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE, Kinesin-like protein KIF11, ... | | 著者 | Yan, Y, Sardana, V, Xu, B, Halczenko, W, Homnick, C, Buser, C.A, Hartman, G.D, Huber, H.E, Kuo, L.C. | | 登録日 | 2003-07-15 | | 公開日 | 2004-01-13 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Inhibition of a mitotic motor protein: where, how, and conformational consequences
J.Mol.Biol., 335, 2004
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3PXN
 | | Crystal structure of the Drosophila kinesin family member Kin10/NOD in complex with divalent manganese and ADP | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein Nod, MANGANESE (II) ION | | 著者 | Cochran, J.C, Zhao, Y.C, Wilcox, D.E, Kull, F.J. | | 登録日 | 2010-12-10 | | 公開日 | 2011-12-21 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | A metal switch for controlling the activity of molecular motor proteins.
Nat.Struct.Mol.Biol., 19, 2012
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3L1C
 | | Kinesin-14 Protein Ncd, T436S Mutant | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Protein claret segregational | | 著者 | Kull, F.J. | | 登録日 | 2009-12-11 | | 公開日 | 2010-08-18 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | A kinesin motor in a force-producing conformation.
Bmc Struct.Biol., 10, 2010
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