6HKY

Eg5-inhibitor complex

Summary for 6HKY

• Entry DOI: 10.2210/pdb6hky/pdb
• Descriptor: Kinesin-like protein KIF11, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: eg5, kif11, eg5-inhibitor, cell cycle
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 3
• Total formula weight: 125782.69

Authors

Talapatra, S.K.,Kozielski, F. (deposition date: 2018-09-09, release date: 2019-09-25, Last modification date: 2024-01-17)

• Primary citation: Indorato, R.L.,Talapatra, S.K.,Lin, F.,Haider, S.,Mackay, S.P.,Kozielski, F.,Skoufias, D.A.; Is the Fate of Clinical Candidate Arry-520 Already Sealed? Predicting Resistance in Eg5-Inhibitor Complexes.; Mol.Cancer Ther., 18:2394-2406, 2019; PubMed: 31488701; DOI: 10.1158/1535-7163.MCT-19-0154

Experimental method

X-RAY DIFFRACTION (2.75 Å)