6G6Y
Eg5-inhibitor complex
Summary for 6G6Y
Entry DOI | 10.2210/pdb6g6y/pdb |
Descriptor | Kinesin-like protein KIF11, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | eg5, kif11, eg5-inhibitor, cell cycle |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 41938.59 |
Authors | Talapatra, S.K.,Kozielski, F.,Tham, C.L. (deposition date: 2018-04-03, release date: 2018-08-08, Last modification date: 2024-01-17) |
Primary citation | Talapatra, S.K.,Tham, C.L.,Guglielmi, P.,Cirilli, R.,Chandrasekaran, B.,Karpoormath, R.,Carradori, S.,Kozielski, F. Crystal structure of the Eg5 - K858 complex and implications for structure-based design of thiadiazole-containing inhibitors. Eur J Med Chem, 156:641-651, 2018 Cited by PubMed: 30031975DOI: 10.1016/j.ejmech.2018.07.006 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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