PDB: 277 件ウェブページステータス検索Chemie searchBIRD

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4MQ9	Crystal structure of Thermus thermophilus RNA polymerase holoenzyme in complex with GE23077 分子名称: (2Z)-2-methylbut-2-enoic acid, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Ho, M.X, Arnold, E, Ebright, R.H, Zhang, Y, Tuske, S. 登録日 2013-09-16 公開日 2014-05-07 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.35 Å) 主引用文献 GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides. Elife, 3, 2014
3UGP	Crystal structure of RNA-polymerase sigma subunit domain 2 complexed with -10 promoter element ssDNA oligo (TATAAT) 分子名称: 5'-D(*TP*GP*TP*AP*TP*AP*AP*TP*GP*GP*G)-3', POTASSIUM ION, RNA polymerase sigma factor 著者 Feklistov, A, Darst, S.A. 登録日 2011-11-02 公開日 2011-12-07 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.697 Å) 主引用文献 Structural basis for promoter-10 element recognition by the bacterial RNA polymerase sigma subunit. Cell(Cambridge,Mass.), 147, 2011
7ZF2	Protomeric substructure from an octameric assembly of M. tuberculosis RNA polymerase in complex with sigma-b initiation factor 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Trapani, S, Bron, P, Lai Kee Him, J, Brodolin, K, Morichaud, Z, Vishwakarma, R. 登録日 2022-03-31 公開日 2023-02-08 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (3.86 Å) 主引用文献 Structural basis of the mycobacterial stress-response RNA polymerase auto-inhibition via oligomerization. Nat Commun, 14, 2023
7P5X	Mycobacterial RNAP with transcriptional activator PafBC 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Mueller, A.U, Kummer, E, Schilling, C.M, Ban, N, Weber-Ban, E. 登録日 2021-07-15 公開日 2021-12-22 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Transcriptional control of mycobacterial DNA damage response by sigma adaptation. Sci Adv, 7, 2021
8AD1	RNA polymerase at U-rich pause bound to RNA putL triple mutant - pause prone, closed clamp state 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Dey, S, Weixlbaumer, A. 登録日 2022-07-07 公開日 2022-10-19 最終更新日 2022-11-02 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Structural insights into RNA-mediated transcription regulation in bacteria. Mol.Cell, 82, 2022
4X8K	Mycobacterium tuberculosis RbpA-SID in complex with SigmaA domain 2 分子名称: 1,2-ETHANEDIOL, RNA polymerase sigma factor SigA, RNA polymerase-binding protein RbpA, ... 著者 Hubin, E.A, Flack, J.E, Tabib-Salazar, A, Paget, M.S, Darst, S.A, Campbell, E.A. 登録日 2014-12-10 公開日 2015-06-03 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.202 Å) 主引用文献 Structural, functional, and genetic analyses of the actinobacterial transcription factor RbpA. Proc.Natl.Acad.Sci.USA, 112, 2015
8U3B	Cryo-EM structure of E. coli NarL-transcription activation complex at 3.2A 分子名称: DNA (69-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Liu, B, Kompaniiets, D, Wang, D. 登録日 2023-09-07 公開日 2024-01-17 最終更新日 2024-02-21 実験手法 ELECTRON MICROSCOPY (3.23 Å) 主引用文献 Structural basis for transcription activation by the nitrate-responsive regulator NarL. Nucleic Acids Res., 52, 2024
7C17	The cryo-EM structure of E. coli CueR transcription activation complex with fully duplex promoter DNA 分子名称: DNA (72-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Fang, C.L, Zhang, Y. 登録日 2020-05-02 公開日 2020-09-30 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (4.22 Å) 主引用文献 CueR activates transcription through a DNA distortion mechanism. Nat.Chem.Biol., 17, 2021
3LEV	HIV-1 antibody 2F5 in complex with epitope scaffold ES2 分子名称: 2F5 ANTIBODY HEAVY CHAIN, 2F5 ANTIBODY LIGHT CHAIN, ADENOSINE-5'-TRIPHOSPHATE, ... 著者 Ofek, G, Guenaga, F.J, Schief, W.R, Skinner, J, Baker, D, Wyatt, R, Kwong, P.D. 登録日 2010-01-15 公開日 2010-09-29 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Elicitation of structure-specific antibodies by epitope scaffolds. Proc.Natl.Acad.Sci.USA, 107, 2010
5X21	Crystal structure of Thermus thermophilus transcription initiation complex with GpA and pseudouridimycin (PUM) 分子名称: (1S)-1,4-anhydro-5-[(N-carbamimidoylglycyl-N~2~-hydroxy-L-glutaminyl)amino]-5-deoxy-1-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-D-ribitol, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Zhang, Y, Ebright, R. 登録日 2017-01-29 公開日 2017-07-05 最終更新日 2022-10-12 実験手法 X-RAY DIFFRACTION (3.323 Å) 主引用文献 Antibacterial Nucleoside-Analog Inhibitor of Bacterial RNA Polymerase. Cell, 169, 2017
5X22	Crystal structure of Thermus thermophilus transcription initiation complex with GpA and CMPcPP 分子名称: 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Zhang, Y, Ebright, R. 登録日 2017-01-29 公開日 2017-07-05 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3.35 Å) 主引用文献 Antibacterial Nucleoside-Analog Inhibitor of Bacterial RNA Polymerase. Cell, 169, 2017
2CW0	Crystal structure of Thermus thermophilus RNA polymerase holoenzyme at 3.3 angstroms resolution 分子名称: DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... 著者 Tuske, S, Sarafianos, S.G, Wang, X, Hudson, B, Sineva, E, Mukhopadhyay, J, Birktoft, J.J, Leroy, O, Ismail, S, Clark Jr, A.D, Dharia, C, Napoli, A, Laptenko, O, Lee, J, Borukhov, S, Ebright, R.H, Arnold, E. 登録日 2005-06-15 公開日 2005-09-20 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation Cell(Cambridge,Mass.), 122, 2005
3LES	2F5 Epitope scaffold ES2 分子名称: RNA polymerase sigma factor, SULFATE ION 著者 Ofek, G, Guenaga, F.J, Schief, W.R, Skinner, J, Wyatt, R, Baker, D, Kwong, P.D. 登録日 2010-01-15 公開日 2010-09-29 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.77 Å) 主引用文献 Elicitation of structure-specific antibodies by epitope scaffolds. Proc.Natl.Acad.Sci.USA, 107, 2010
5XJ0	T. thermophilus RNA polymerase holoenzyme bound with gp39 and gp76 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Ooi, W.Y, Murayama, Y, Mekler, V, Minakhin, L, Severinov, K, Yokoyama, S, Sekine, S. 登録日 2017-04-28 公開日 2017-12-20 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (4.004 Å) 主引用文献 A Thermus phage protein inhibits host RNA polymerase by preventing template DNA strand loading during open promoter complex formation Nucleic Acids Res., 46, 2018
3EQL	Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with antibiotic myxopyronin 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Vassylyev, D.G, Vassylyeva, M.N, Artsimovitch, I. 登録日 2008-09-30 公開日 2008-10-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Transcription inactivation through local refolding of the RNA polymerase structure. Nature, 457, 2009
8JKE	AfsR(T337A) transcription activation complex 分子名称: DNA(65-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Wang, Y, Zheng, J. 登録日 2023-06-01 公開日 2024-02-14 最終更新日 2024-04-03 実験手法 ELECTRON MICROSCOPY (3.67 Å) 主引用文献 Structural and functional characterization of AfsR, an SARP family transcriptional activator of antibiotic biosynthesis in Streptomyces. Plos Biol., 22, 2024
5YIX	Caulobacter crescentus GcrA sigma-interacting domain (SID) in complex with domain 2 of sigma 70 分子名称: (R,R)-2,3-BUTANEDIOL, Cell cycle regulatory protein GcrA, RNA polymerase sigma factor RpoD, ... 著者 Wu, X, Zhang, Y. 登録日 2017-10-06 公開日 2018-03-21 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.302 Å) 主引用文献 Structural insights into the unique mechanism of transcription activation by Caulobacter crescentus GcrA. Nucleic Acids Res., 46, 2018
3WOD	RNA polymerase-gp39 complex 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Tagami, S, Sekine, S, Minakhin, L, Esyunina, D, Akasaka, R, Shirouzu, M, Kulbachinskiy, A, Severinov, K, Yokoyama, S. 登録日 2013-12-26 公開日 2014-03-12 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 Structural basis for promoter specificity switching of RNA polymerase by a phage factor. Genes Dev., 28, 2014
8DY9	Streptomyces venezuelae RNAP unconstrained open promoter complex with WhiA and WhiB transcription factors 分子名称: DNA (38-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Lilic, M, Campbell, E.A. 登録日 2022-08-03 公開日 2023-03-01 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.12 Å) 主引用文献 Structural basis of dual activation of cell division by the actinobacterial transcription factors WhiA and WhiB. Proc.Natl.Acad.Sci.USA, 120, 2023
8DY7	Streptomyces venezuelae RNAP transcription open promoter complex with WhiA and WhiB transcription factors 分子名称: DNA (71-MER), DNA (78-MER), DNA-directed RNA polymerase subunit alpha, ... 著者 Lilic, M, Campbell, E.A. 登録日 2022-08-03 公開日 2023-03-01 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.18 Å) 主引用文献 Structural basis of dual activation of cell division by the actinobacterial transcription factors WhiA and WhiB. Proc.Natl.Acad.Sci.USA, 120, 2023
2BE5	Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with inhibitor tagetitoxin 分子名称: DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... 著者 Vassylyev, D.G, Svetlov, V, Vassylyeva, M.N, Perederina, A, Igarashi, N, Matsugaki, N, Wakatsuki, S, Artsimovitch, I, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2005-10-22 公開日 2005-11-08 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural basis for transcription inhibition by tagetitoxin Nat.Struct.Mol.Biol., 12, 2005
3DXJ	Crystal structure of thermus thermophilus rna polymerase holoenzyme in complex with the antibiotic myxopyronin 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, BACTERIAL RNA POLYMERASE BETA SUBUNIT; CHAIN C, M, ... 著者 Das, K, Arnold, E. 登録日 2008-07-24 公開日 2008-10-14 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 The RNA polymerase "switch region" is a target for inhibitors. Cell(Cambridge,Mass.), 135, 2008
3UGO	Crystal structure of RNA-polymerase sigma subunit domain 2 complexed with -10 promoter element ssDNA oligo (TACAAT) 分子名称: 5'-D(*TP*GP*TP*AP*CP*AP*AP*TP*GP*GP*G)-3', POTASSIUM ION, RNA polymerase sigma factor 著者 Feklistov, A, Darst, S.A. 登録日 2011-11-02 公開日 2011-12-07 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.096 Å) 主引用文献 Structural basis for promoter-10 element recognition by the bacterial RNA polymerase sigma subunit. Cell(Cambridge,Mass.), 147, 2011
1SIG	CRYSTAL STRUCTURE OF A SIGMA70 SUBUNIT FRAGMENT FROM ESCHERICHIA COLI RNA POLYMERASE 分子名称: RNA POLYMERASE PRIMARY SIGMA FACTOR 著者 Malhotra, A, Severinova, E, Darst, S.A. 登録日 1997-02-18 公開日 1997-05-15 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal structure of a sigma 70 subunit fragment from E. coli RNA polymerase. Cell(Cambridge,Mass.), 87, 1996
1SMY	Structural basis for transcription regulation by alarmone ppGpp 分子名称: DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... 著者 Artsimovitch, I, Patlan, V, Sekine, S, Vassylyeva, M.N, Hosaka, T, Ochi, K, Yokoyama, S, Vassylyev, D.G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2004-03-10 公開日 2004-05-18 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural basis for transcription regulation by alarmone ppGpp Cell(Cambridge,Mass.), 117, 2004

 

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