6YHY
 
 | | A lid blocking mechanism of a cone snail toxin revealed at the atomic level | | 分子名称: | Conk-S1 | | 著者 | Saikia, C, Altman-Gueta, H, Dym, O, Frolow, F, Gurevitz, M, Gordon, D, Reuveny, E, Karbat, I. | | 登録日 | 2020-03-31 | | 公開日 | 2021-04-14 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | A Molecular Lid Mechanism of K + Channel Blocker Action Revealed by a Cone Peptide.
J.Mol.Biol., 433, 2021
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9PTI
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6A5I
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5EZD
 | | Crystal structure of a Hepatocyte growth factor activator inhibitor-1 (HAI-1) fragment covering the PKD-like 'internal' domain and Kunitz domain 1 | | 分子名称: | ACETATE ION, Kunitz-type protease inhibitor 1, POTASSIUM ION | | 著者 | Hong, Z, Andreasen, P.A, Morth, J.P, Jensen, J.K. | | 登録日 | 2015-11-26 | | 公開日 | 2016-05-18 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal Structure of a Two-domain Fragment of Hepatocyte Growth Factor Activator Inhibitor-1: FUNCTIONAL INTERACTIONS BETWEEN THE KUNITZ-TYPE INHIBITOR DOMAIN-1 AND THE NEIGHBORING POLYCYSTIC KIDNEY DISEASE-LIKE DOMAIN.
J.Biol.Chem., 291, 2016
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8PTI
 | | CRYSTAL STRUCTURE OF A Y35G MUTANT OF BOVINE PANCREATIC TRYPSIN INHIBITOR | | 分子名称: | BOVINE PANCREATIC TRYPSIN INHIBITOR | | 著者 | Housset, D, Kim, K.-S, Fuchs, J, Woodward, C, Wlodawer, A. | | 登録日 | 1990-12-17 | | 公開日 | 1991-04-15 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal structure of a Y35G mutant of bovine pancreatic trypsin inhibitor.
J.Mol.Biol., 220, 1991
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6KZF
 | | Racemic X-ray Structure of Calcicludine | | 分子名称: | D-calcicludine, Kunitz-type serine protease inhibitor homolog calcicludine | | 著者 | Qu, Q, Gao, S, Liu, L. | | 登録日 | 2019-09-24 | | 公開日 | 2019-11-06 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.52 Å) | | 主引用文献 | Synthesis of Disulfide Surrogate Peptides Incorporating Large-Span Surrogate Bridges Through a Native-Chemical-Ligation-Assisted Diaminodiacid Strategy
Angew.Chem.Int.Ed.Engl., 59, 2020
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7PTI
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2ZJX
 | | Bovine pancreatic trypsin inhibitor (BPTI) containing only the [5,55] disulfide bond | | 分子名称: | Pancreatic trypsin inhibitor, SULFATE ION | | 著者 | Islam, M.M, Sohya, S, Noguchi, K, Yohda, M, Kuroda, Y. | | 登録日 | 2008-03-11 | | 公開日 | 2008-10-21 | | 最終更新日 | 2021-11-10 | | 実験手法 | X-RAY DIFFRACTION (1.09 Å) | | 主引用文献 | Crystal structure of an extensively simplified variant of bovine pancreatic trypsin inhibitor in which over one-third of the residues are alanines
Proc.Natl.Acad.Sci.Usa, 105, 2008
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2ZVX
 | | Structure of a BPTI-[5,55] variant containing Gly/Val at the 14/38th positions | | 分子名称: | Pancreatic trypsin inhibitor, SULFATE ION | | 著者 | Islam, M.M, Sohya, S, Noguchi, K, Yohda, M, Kuroda, Y. | | 登録日 | 2008-11-24 | | 公開日 | 2009-10-13 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.09 Å) | | 主引用文献 | Thermodynamic and structural analysis of highly stabilized BPTIs by single and double mutations
Proteins, 77, 2009
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6NAN
 | | NMR structure determination of Ixolaris and Factor X interaction reveals a noncanonical mechanism of Kunitz inhibition | | 分子名称: | Ixolaris | | 著者 | De Paula, V.S, Sgourakis, N.G, Francischetti, I.M.B, Almeida, F.C.L, Monteiro, R.Q, Valente, A.P. | | 登録日 | 2018-12-06 | | 公開日 | 2019-06-12 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | NMR structure determination of Ixolaris and factor X(a) interaction reveals a noncanonical mechanism of Kunitz inhibition.
Blood, 134, 2019
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6F1F
 | | The methylene thioacetal BPTI (Bovine Pancreatic Trypsin Inhibitor) mutant structure | | 分子名称: | GLYCEROL, Pancreatic trypsin inhibitor, SULFATE ION | | 著者 | Lansky, S, Mousa, R, Metanis, N, Shoham, G. | | 登録日 | 2017-11-21 | | 公開日 | 2018-07-18 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.716 Å) | | 主引用文献 | BPTI folding revisited: switching a disulfide into methylene thioacetal reveals a previously hidden path.
Chem Sci, 9, 2018
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1D0D
 | | CRYSTAL STRUCTURE OF TICK ANTICOAGULANT PROTEIN COMPLEXED WITH BOVINE PANCREATIC TRYPSIN INHIBITOR | | 分子名称: | ANTICOAGULANT PROTEIN, PANCREATIC TRYPSIN INHIBITOR, SULFATE ION | | 著者 | St.Charles, R, Padmanabhan, K, Arni, R.V, Padmanabhan, K.P, Tulinsky, A. | | 登録日 | 1999-09-09 | | 公開日 | 2000-09-09 | | 最終更新日 | 2018-04-04 | | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | | 主引用文献 | Structure of tick anticoagulant peptide at 1.6 A resolution complexed with bovine pancreatic trypsin inhibitor.
Protein Sci., 9, 2000
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1DTX
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6PTI
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6Q61
 | | Pore-modulating toxins exploit inherent slow inactivation to block K+ channels | | 分子名称: | Kunitz-type conkunitzin-S1, SULFATE ION | | 著者 | Karbat, I, Gueta, H, Fine, S, Szanto, T, Hamer-Rogotner, S, Dym, O, Frolow, F, Gordon, D, Panyi, G, Gurevitz, M, Reuveny, E. | | 登録日 | 2018-12-10 | | 公開日 | 2019-08-21 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Pore-modulating toxins exploit inherent slow inactivation to block K+channels.
Proc.Natl.Acad.Sci.USA, 116, 2019
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6Q6C
 | | Pore-modulating toxins exploit inherent slow inactivation to block K+ channels | | 分子名称: | 1,2-ETHANEDIOL, Kunitz-type conkunitzin-S1, NITRATE ION, ... | | 著者 | Karbat, I, Gueta, H, Fine, S, Szanto, T, Hamer-Rogotner, S, Dym, O, Frolow, F, Gordon, D, Panyi, G, Gurevitz, M, Reuveny, E. | | 登録日 | 2018-12-10 | | 公開日 | 2019-08-21 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Pore-modulating toxins exploit inherent slow inactivation to block K+channels.
Proc.Natl.Acad.Sci.USA, 116, 2019
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5NMV
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3OFW
 | | Crystal structure of recombinant Kunitz Type serine protease Inhibitor-1 from the Carribean sea anemone stichodactyla helianthus | | 分子名称: | CHLORIDE ION, Kunitz-type proteinase inhibitor SHPI-1 | | 著者 | Garcia-Fernandez, R, Redecke, L, Pons, T, Perbandt, M, Talavera, A, Gil, D, Gonzalez, Y, de los Angeles Chavez, M, Betzel, C. | | 登録日 | 2010-08-16 | | 公開日 | 2011-08-17 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structure of the recombinant BPTI/Kunitz-type inhibitor rShPI-1A from the marine invertebrate Stichodactyla helianthus.
Acta Crystallogr.,Sect.F, 68, 2012
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5PTI
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4PTI
 | | THE GEOMETRY OF THE REACTIVE SITE AND OF THE PEPTIDE GROUPS IN TRYPSIN, TRYPSINOGEN AND ITS COMPLEXES WITH INHIBITORS | | 分子名称: | TRYPSIN INHIBITOR | | 著者 | Huber, R, Kukla, D, Ruehlmann, A, Epp, O, Formanek, H, Deisenhofer, J, Steigemann, W. | | 登録日 | 1982-09-27 | | 公開日 | 1983-01-18 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | The Geometry of the Reactive Site and of the Peptide Groups in Trypsin, Trypsinogen and its Complexes with Inhibitors
Acta Crystallogr.,Sect.B, 39, 1983
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4BQD
 | | KD1 of human TFPI in complex with a synthetic peptide | | 分子名称: | GLYCEROL, PEPTIDE, TISSUE FACTOR PATHWAY INHIBITOR (LIPOPROTEIN-ASSOCIATED COAGULATION INHIBITOR) VARIANT | | 著者 | Griessner, A, Brandstetter, H. | | 登録日 | 2013-05-30 | | 公開日 | 2013-12-04 | | 最終更新日 | 2019-07-17 | | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | | 主引用文献 | Small Peptides Blocking Inhibition of Factor Xa and Tissue Factor-Factor Viia by Tissue Factor Pathway Inhibitor (Tfpi)
J.Biol.Chem., 289, 2014
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4DTG
 | | Hemostatic effect of a monoclonal antibody mAb 2021 blocking the interaction between FXa and TFPI in a rabbit hemophilia model | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, Humanized recombinant FAB fragment, ... | | 著者 | Svensson, L.A, Breinholt, J, Krogh, B.O, Hilden, I. | | 登録日 | 2012-02-21 | | 公開日 | 2012-06-13 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Hemostatic effect of a monoclonal antibody mAb 2021 blocking the interaction between FXa and TFPI in a rabbit hemophilia model.
Blood, 119, 2012
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3LDI
 | | Crystal structure of aprotinin in complex with sucrose octasulfate: unusual interactions and implication for heparin binding | | 分子名称: | GLYCEROL, MERCURY (II) ION, Pancreatic trypsin inhibitor, ... | | 著者 | Yang, I.S, Kim, T.G, Park, B.S, Kim, K.H. | | 登録日 | 2010-01-13 | | 公開日 | 2010-06-23 | | 最終更新日 | 2014-02-12 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal structures of aprotinin and its complex with sucrose octasulfate reveal multiple modes of interactions with implications for heparin binding
Biochem.Biophys.Res.Commun., 397, 2010
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3LDJ
 | | Crystal structure of aprotinin in complex with sucrose octasulfate: unusual interactions and implication for heparin binding | | 分子名称: | 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, ACETATE ION, Pancreatic trypsin inhibitor | | 著者 | Yang, I.S, Kim, T.G, Park, B.S, Kim, K.H. | | 登録日 | 2010-01-13 | | 公開日 | 2010-09-15 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Crystal structures of aprotinin and its complex with sucrose octasulfate reveal multiple modes of interactions with implications for heparin binding.
Biochem.Biophys.Res.Commun., 2010
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3LDM
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