6SJA
 
 | | Structure of HPV16 E6 oncoprotein in complex with IRF3 LxxLL motif | | 分子名称: | Maltose/maltodextrin-binding periplasmic protein,Interferon regulatory factor 3, Protein E6, ZINC ION, ... | | 著者 | Suarez, I.P, Cousido-Siah, A, Bonhoure, A, Mitschler, A, Podjarny, A, Trave, G. | | 登録日 | 2019-08-13 | | 公開日 | 2019-09-04 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Deciphering de molecular and structural interaction between IRF3 and HPV16 E6
To be published
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6SIV
 | | Structure of HPV16 E6 oncoprotein in complex with mutant IRF3 LxxLL motif | | 分子名称: | Maltose/maltodextrin-binding periplasmic protein,Interferon regulatory factor 3, Protein E6, ZINC ION, ... | | 著者 | Suarez, I.P, Cousido-Siah, A, Bonhoure, A, Mitschler, A, Podjarny, A, Trave, G. | | 登録日 | 2019-08-12 | | 公開日 | 2019-08-21 | | 最終更新日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (1.752 Å) | | 主引用文献 | Deciphering the molecular and structural interaction between IRF3 and HPV16 E6
To be published
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8BTJ
 | | Murine cytomegalovirus protein M35 | | 分子名称: | (R,R)-2,3-BUTANEDIOL, MALONATE ION, Protein M35 | | 著者 | Schmelz, S, Van den Heuvel, J, Blankenfeldt, W. | | 登録日 | 2022-11-29 | | 公開日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | | 主引用文献 | The Cytomegalovirus M35 Protein Directly Binds to the Interferon-beta Enhancer and Modulates Transcription of Ifnb1 and Other IRF3-Driven Genes.
J.Virol., 97, 2023
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1ZOQ
 | | IRF3-CBP complex | | 分子名称: | CREB-binding protein, Interferon regulatory factor 3 | | 著者 | Qin, B, Lin, K. | | 登録日 | 2005-05-13 | | 公開日 | 2006-03-21 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.37 Å) | | 主引用文献 | Crystal structure of IRF-3 in complex with CBP.
Structure, 13, 2005
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1QWT
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2O61
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1T2K
 | | Structure Of The DNA Binding Domains Of IRF3, ATF-2 and Jun Bound To DNA | | 分子名称: | 31-MER, Cyclic-AMP-dependent transcription factor ATF-2, Interferon regulatory factor 3, ... | | 著者 | Panne, D, Maniatis, T, Harrison, S.C. | | 登録日 | 2004-04-21 | | 公開日 | 2004-11-16 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Crystal structure of ATF-2/c-Jun and IRF-3 bound to the interferon-beta enhancer.
Embo J., 23, 2004
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3A77
 | | The crystal structure of phosphorylated IRF-3 | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, ACETIC ACID, Interferon regulatory factor 3 | | 著者 | Takahasi, K, Horiuchi, M, Noda, N.N, Inagaki, F. | | 登録日 | 2009-09-17 | | 公開日 | 2010-08-04 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Ser386 phosphorylation of transcription factor IRF-3 induces dimerization and association with CBP/p300 without overall conformational change.
Genes Cells, 15, 2010
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2PI0
 | | Crystal Structure of IRF-3 bound to the PRDIII-I regulatory element of the human interferon-B enhancer | | 分子名称: | Interferon regulatory factor 3, PRDIII-I region of human interferon-B promoter strand 1, PRDIII-I region of human interferon-B promoter strand 2 | | 著者 | Escalante, C.R, Nistal-Villan, E, Leyi, S, Garcia-Sastre, A, Aggarwal, A.K. | | 登録日 | 2007-04-12 | | 公開日 | 2007-10-30 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | | 主引用文献 | Structure of IRF-3 bound to the PRDIII-I regulatory element of the human interferon-beta enhancer.
Mol.Cell, 26, 2007
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2O6G
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1J2F
 | | X-ray crystal structure of IRF-3 and its functional implications | | 分子名称: | Interferon regulatory factor 3 | | 著者 | Takahasi, K, Noda, N, Horiuchi, M, Mori, M, Okabe, Y, Fukuhara, Y, Terasawa, H, Fujita, T, Inagaki, F. | | 登録日 | 2003-01-04 | | 公開日 | 2003-11-25 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | X-ray crystal structure of IRF-3 and its functional implications.
Nat.Struct.Biol., 10, 2003
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5JEJ
 | | Phosphorylated STING in complex with IRF-3 CTD | | 分子名称: | Interferon regulatory factor 3, Stimulator of interferon genes protein | | 著者 | Li, P, Shu, C. | | 登録日 | 2016-04-18 | | 公開日 | 2016-06-15 | | 最終更新日 | 2016-06-29 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins.
Proc.Natl.Acad.Sci.USA, 113, 2016
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5JEK
 | | Phosphorylated MAVS in complex with IRF-3 | | 分子名称: | Interferon regulatory factor 3, MAVS peptide | | 著者 | Zhao, B, Li, P. | | 登録日 | 2016-04-18 | | 公開日 | 2016-06-15 | | 最終更新日 | 2016-06-29 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins.
Proc.Natl.Acad.Sci.USA, 113, 2016
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5JEL
 | | Phosphorylated TRIF in complex with IRF-3 | | 分子名称: | Interferon regulatory factor 3, Phosphorylated TRIF peptide | | 著者 | Zhao, B, Li, P. | | 登録日 | 2016-04-18 | | 公開日 | 2016-06-15 | | 最終更新日 | 2016-06-29 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins.
Proc.Natl.Acad.Sci.USA, 113, 2016
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5JEO
 | | Phosphorylated Rotavirus NSP1 in complex with IRF-3 | | 分子名称: | Interferon regulatory factor 3, PHOSPHATE ION, Rotavirus NSP1 peptide | | 著者 | Zhao, B, Li, P. | | 登録日 | 2016-04-18 | | 公開日 | 2016-06-15 | | 最終更新日 | 2016-06-29 | | 実験手法 | X-RAY DIFFRACTION (1.719 Å) | | 主引用文献 | Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins.
Proc.Natl.Acad.Sci.USA, 113, 2016
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5JER
 | | Structure of Rotavirus NSP1 bound to IRF-3 | | 分子名称: | Interferon regulatory factor 3, Rotavirus NSP1 peptide | | 著者 | Zhao, B, Li, P. | | 登録日 | 2016-04-18 | | 公開日 | 2016-06-15 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.913 Å) | | 主引用文献 | Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins.
Proc.Natl.Acad.Sci.USA, 113, 2016
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7JFM
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7JFL
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5JEM
 | | Complex of IRF-3 with CBP | | 分子名称: | CREB-binding protein, Interferon regulatory factor 3 | | 著者 | Zhao, B, Li, P. | | 登録日 | 2016-04-18 | | 公開日 | 2016-06-15 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins.
Proc.Natl.Acad.Sci.USA, 113, 2016
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3QU6
 | | Crystal structure of IRF-3 DBD free form | | 分子名称: | CHLORIDE ION, IRF3 protein, SODIUM ION, ... | | 著者 | De Ioannes, P.E, Escalante, C.R, Aggarwal, A.K. | | 登録日 | 2011-02-23 | | 公開日 | 2011-06-01 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structures of apo IRF-3 and IRF-7 DNA binding domains: effect of loop L1 on DNA binding.
Nucleic Acids Res., 39, 2011
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4JC5
 | | Immune activator bound to receptor | | 分子名称: | (9-oxoacridin-10(9H)-yl)acetic acid, Transmembrane protein 173 | | 著者 | Deimling, T, Hopfner, K.P. | | 登録日 | 2013-02-21 | | 公開日 | 2013-05-08 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Species-specific detection of the antiviral small-molecule compound CMA by STING.
Embo J., 32, 2013
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4EF4
 | | Crystal structure of STING CTD complex with c-di-GMP | | 分子名称: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), CALCIUM ION, Transmembrane protein 173 | | 著者 | Ouyang, S, Ru, H, Shaw, N, Jiang, Y, Niu, F, Zhu, Y, Qiu, W, Li, Y, Liu, Z.-J. | | 登録日 | 2012-03-29 | | 公開日 | 2012-05-16 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.147 Å) | | 主引用文献 | Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding
Immunity, 36, 2012
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4EF5
 | | Crystal structure of STING CTD | | 分子名称: | Transmembrane protein 173 | | 著者 | Ouyang, S, Ru, H, Shaw, N, Jiang, Y, Niu, F, Zhu, Y, Qiu, W, Li, Y, Liu, Z.-J. | | 登録日 | 2012-03-29 | | 公開日 | 2012-05-16 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding
Immunity, 36, 2012
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4H9K
 | | Crystal structure of cleavage site mutant of Npro of classical swine fever virus. | | 分子名称: | Hog cholera virus, SULFATE ION, ZINC ION | | 著者 | Gottipati, K, Ruggli, N, Gerber, M, Tratschin, J.-D, Benning, M, Bellamy, H, Choi, K.H. | | 登録日 | 2012-09-24 | | 公開日 | 2013-10-30 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.599 Å) | | 主引用文献 | The Structure of Classical Swine Fever Virus N(pro): A Novel Cysteine Autoprotease and Zinc-Binding Protein Involved in Subversion of Type I Interferon Induction.
Plos Pathog., 9, 2013
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4H9J
 | | Crystal structure of N-terminal protease (Npro) of classical swine fever virus. | | 分子名称: | Hog cholera virus | | 著者 | Gottipati, K, Ruggli, N, Gerber, M, Tratschin, J.-D, Benning, M, Bellamy, H, Choi, K.H. | | 登録日 | 2012-09-24 | | 公開日 | 2013-10-30 | | 最終更新日 | 2018-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | The Structure of Classical Swine Fever Virus N(pro): A Novel Cysteine Autoprotease and Zinc-Binding Protein Involved in Subversion of Type I Interferon Induction.
Plos Pathog., 9, 2013
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