6UH0
 
 | | Human Carbonic Anhydrase 2 in complex with SB4-202 | | 分子名称: | 4-methyl-1lambda~6~,2,4-benzothiadiazine-1,1,3(2H,4H)-trione, Carbonic anhydrase 2, ZINC ION | | 著者 | Murray, A.B, Lomelino, C.L, McKenna, R. | | 登録日 | 2019-09-26 | | 公開日 | 2019-12-18 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.306 Å) | | 主引用文献 | "A Sweet Combination": Developing Saccharin and Acesulfame K Structures for Selectively Targeting the Tumor-Associated Carbonic Anhydrases IX and XII.
J.Med.Chem., 63, 2020
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3TR0
 | | Structure of guanylate kinase (gmk) from Coxiella burnetii | | 分子名称: | GUANOSINE-5'-MONOPHOSPHATE, Guanylate kinase, SULFATE ION | | 著者 | Cheung, J, Franklin, M, Rudolph, M, Cassidy, M, Gary, E, Burshteyn, F, Love, J. | | 登録日 | 2011-09-09 | | 公開日 | 2011-09-21 | | 最終更新日 | 2024-11-27 | | 実験手法 | X-RAY DIFFRACTION (1.851 Å) | | 主引用文献 | Structural genomics for drug design against the pathogen Coxiella burnetii.
Proteins, 83, 2015
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6UFC
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1IZC
 | | Crystal Structure Analysis of Macrophomate synthase | | 分子名称: | MAGNESIUM ION, PYRUVIC ACID, macrophomate synthase intermolecular Diels-Alderase | | 著者 | Ose, T, Watanabe, K, Mie, T, Honma, M, Watanabe, H, Yao, M, Oikawa, H, Tanaka, I. | | 登録日 | 2002-10-01 | | 公開日 | 2003-04-01 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Insight into a natural Diels-Alder reaction from the structure of macrophomate synthase.
Nature, 422, 2003
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3NVX
 | | Molecular mechanism of guidance cue recognition | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Protein A39 | | 著者 | Liu, H, Juo, Z, Shim, A, Focia, P, Chen, X, Garcia, C, He, X. | | 登録日 | 2010-07-08 | | 公開日 | 2010-09-15 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural Basis of Semaphorin-Plexin Recognition and Viral Mimicry from Sema7A and A39R Complexes with PlexinC1.
Cell(Cambridge,Mass.), 142, 2010
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1J1G
 | | Crystal structure of the RNase MC1 mutant N71S in complex with 5'-GMP | | 分子名称: | GUANOSINE-5'-MONOPHOSPHATE, Ribonuclease MC1 | | 著者 | Numata, T, Suzuki, A, Kakuta, Y, Kimura, K, Yao, M, Tanaka, I, Yoshida, Y, Ueda, T, Kimura, M. | | 登録日 | 2002-12-04 | | 公開日 | 2003-05-20 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Crystal Structures of the Ribonuclease MC1 Mutants N71T and N71S in Complex with 5'-GMP: Structural Basis for Alterations in Substrate Specificity
Biochemistry, 42, 2003
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2DDD
 | | Unique behavior of a histidine responsible for an engineered green-to-red photoconversion process | | 分子名称: | MAGNESIUM ION, SODIUM ION, photoconvertible fluorescent protein | | 著者 | Shimizu, H, Tsutsui, H, Nukina, N, Miyawaki, A. | | 登録日 | 2006-01-27 | | 公開日 | 2006-03-07 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | The E1 mechanism in photo-induced beta-elimination reactions for green-to-red conversion of fluorescent proteins
Chem.Biol., 16, 2009
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3KSO
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4EMH
 | | Crystal structure of SpLsm4 | | 分子名称: | Probable U6 snRNA-associated Sm-like protein LSm4 | | 著者 | Jiang, S.M, Wu, D.H, Song, H.W. | | 登録日 | 2012-04-12 | | 公開日 | 2012-06-13 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal Structures of Lsm3, Lsm4 and Lsm5/6/7 from Schizosaccharomyces pombe.
Plos One, 7, 2012
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1RTE
 | | X-ray Structure of Cyanide Derivative of Truncated Hemoglobin N (trHbN) from Mycobacterium Tuberculosis | | 分子名称: | CYANIDE ION, Hemoglobin-like protein HbN, PROTOPORPHYRIN IX CONTAINING FE, ... | | 著者 | Milani, M, Guertin, M, Boffi, A, Antonini, G, Bocedi, A, Mattu, M, Bolognesi, M, Ascenzi, P. | | 登録日 | 2003-12-10 | | 公開日 | 2004-07-27 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Cyanide binding to truncated hemoglobins: a crystallographic and kinetic study
Biochemistry, 43, 2004
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6QVW
 | | Solution structure of the free FOXO1 DNA binding domain | | 分子名称: | Forkhead box protein O1 | | 著者 | Psenakova, K, Obsil, T, Veverka, V, Obsilova, V, Kohoutova, K. | | 登録日 | 2019-03-05 | | 公開日 | 2019-09-04 | | 最終更新日 | 2024-06-19 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Forkhead Domains of FOXO Transcription Factors Differ in both Overall Conformation and Dynamics.
Cells, 8, 2019
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3TKS
 | | Crystal structure of full-length human peroxiredoxin 4 in three different redox states | | 分子名称: | PEROXIDE ION, Peroxiredoxin-4 | | 著者 | Wang, X, Wang, L, Wang, X, Sun, F, Wang, C.-C. | | 登録日 | 2011-08-28 | | 公開日 | 2011-10-05 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural insights into the peroxidase activity and inactivation of human peroxiredoxin 4
Biochem.J., 2011
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6UMX
 | | Structural basis for specific inhibition of extracellular activation of pro/latent myostatin by SRK-015 | | 分子名称: | GL29H4-16 Fab Heavy Chain,GL29H4-16 Fab Heavy Chain, GL29H4-16 Fab Light Chain,GL29H4-16 Fab Light Chain, GLYCEROL, ... | | 著者 | Dagbay, K.B, Treece, E, Streich Jr, F.C, Jackson, J.W, Faucette, R.R, Nikiforov, A, Lin, S.C, Bostion, C.J, Nicholls, S.B, Capili, A.D, Carven, G.J. | | 登録日 | 2019-10-10 | | 公開日 | 2020-02-26 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (2.79 Å) | | 主引用文献 | Structural basis of specific inhibition of extracellular activation of pro- or latent myostatin by the monoclonal antibody SRK-015.
J.Biol.Chem., 295, 2020
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3O6W
 | | Crystal structure of monomeric KlHxk1 in crystal form VIII (open state) | | 分子名称: | GLYCEROL, Hexokinase, PHOSPHATE ION | | 著者 | Kuettner, E.B, Kettner, K, Keim, A, Kriegel, T.M, Strater, N. | | 登録日 | 2010-07-29 | | 公開日 | 2010-10-13 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | | 主引用文献 | Crystal Structure of Hexokinase KlHxk1 of Kluyveromyces lactis: A MOLECULAR BASIS FOR UNDERSTANDING THE CONTROL OF YEAST HEXOKINASE FUNCTIONS VIA COVALENT MODIFICATION AND OLIGOMERIZATION.
J.Biol.Chem., 285, 2010
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3TVO
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3O90
 | | High resolution crystal structures of Streptococcus pneumoniae nicotinamidase with trapped intermediates provide insights into catalytic mechanism and inhibition by aldehydes | | 分子名称: | ZINC ION, nicotinamidase | | 著者 | French, J.B, Cen, Y, Sauve, A.A, Ealick, S.E. | | 登録日 | 2010-08-03 | | 公開日 | 2011-01-12 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | | 主引用文献 | High-resolution crystal structures of Streptococcus pneumoniae nicotinamidase with trapped intermediates provide insights into the catalytic mechanism and inhibition by aldehydes .
Biochemistry, 49, 2010
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1ISF
 | | Crystal Structure Analysis of BST-1/CD157 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, bone marrow stromal cell antigen 1 | | 著者 | Yamamoto-Katayama, S, Ariyoshi, M, Ishihara, K, Hirano, T, Jingami, H, Morikawa, K. | | 登録日 | 2001-12-05 | | 公開日 | 2002-03-13 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystallographic studies on human BST-1/CD157 with ADP-ribosyl cyclase and NAD glycohydrolase activities.
J.Mol.Biol., 316, 2002
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6QZS
 | | 14-3-3 sigma in complex with FOXO1 pS256 peptide | | 分子名称: | 14-3-3 protein sigma, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FOXO1 pS256 site, ... | | 著者 | Ottmann, C, Wolter, M, Lau, R.A. | | 登録日 | 2019-03-12 | | 公開日 | 2019-07-31 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | AMPK and AKT protein kinases hierarchically phosphorylate the N-terminus of the FOXO1 transcription factor, modulating interactions with 14-3-3 proteins.
J.Biol.Chem., 294, 2019
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8E0F
 | | Human Adenosine Deaminase Acting on dsRNA (ADAR2-RD) bound to dsRNA containing a G-G pair adjacent to the target site | | 分子名称: | Double-stranded RNA-specific editase 1, INOSITOL HEXAKISPHOSPHATE, RNA (5-R(*GP*CP*UP*CP*GP*CP*GP*AP*UP*GP*CP*GP*(8AZ)P*GP*AP*GP*GP*GP*CP* UP*CP*UP*GP*AP*UP*AP*GP*CP*UP*AP*CP*G)-3), ... | | 著者 | Wilcox, X.E, Fisher, A.J, Beal, P.A. | | 登録日 | 2022-08-09 | | 公開日 | 2022-10-26 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | ADAR activation by inducing a syn conformation at guanosine adjacent to an editing site.
Nucleic Acids Res., 50, 2022
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3L14
 | | Human Carbonic Anhydrase II complexed with Althiazide | | 分子名称: | 4-AMINO-6-CHLOROBENZENE-1,3-DISULFONAMIDE, Carbonic anhydrase 2, ZINC ION | | 著者 | Quirit, J.G, Robbins, A, Genis, C, Tu, C, Silverman, D.N, McKenna, R. | | 登録日 | 2009-12-10 | | 公開日 | 2011-01-05 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.22 Å) | | 主引用文献 | The Promiscuous Nature of Althiazide in Adducts with CA II and CA IX Mimic
To be Published
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2DJX
 | | Crystal structure of native Trypanosoma cruzi dihydroorotate dehydrogenase | | 分子名称: | COBALT HEXAMMINE(III), Dihydroorotate Dehydrogenase, FLAVIN MONONUCLEOTIDE | | 著者 | Inaoka, D.K, Shimizu, H, Sakamoto, K, Shiba, T, Kurisu, G, Nara, T, Aoki, T, Harada, S, Kita, K. | | 登録日 | 2006-04-05 | | 公開日 | 2007-06-26 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | | 主引用文献 | Crystal structure of native Trypanosoma cruzi dihydroorotate dehydrogenase
To be Published
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3TZ4
 | | Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/S-alpha-chloroisocaproate complex with ADP | | 分子名称: | (2S)-2-chloro-4-methylpentanoic acid, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Tso, S.C, Chuang, J.L, Gui, W.J, Wynn, R.M, Li, J, Chuang, D.T. | | 登録日 | 2011-09-27 | | 公開日 | 2012-10-03 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase.
Proc.Natl.Acad.Sci.USA, 110, 2013
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3L2D
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4HX8
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3O91
 | | High resolution crystal structures of Streptococcus pneumoniae nicotinamidase with trapped intermediates provide insights into catalytic mechanism and inhibition by aldehydes | | 分子名称: | ZINC ION, nicotinamidase | | 著者 | French, J.B, Cen, Y, Sauve, A.A, Ealick, S.E. | | 登録日 | 2010-08-03 | | 公開日 | 2011-01-12 | | 最終更新日 | 2025-03-26 | | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | | 主引用文献 | High-resolution crystal structures of Streptococcus pneumoniae nicotinamidase with trapped intermediates provide insights into the catalytic mechanism and inhibition by aldehydes .
Biochemistry, 49, 2010
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