8E0F

Human Adenosine Deaminase Acting on dsRNA (ADAR2-RD) bound to dsRNA containing a G-G pair adjacent to the target site

Summary for 8E0F

• Entry DOI: 10.2210/pdb8e0f/pdb
• Descriptor: Double-stranded RNA-specific editase 1, RNA (5-R(*GP*CP*UP*CP*GP*CP*GP*AP*UP*GP*CP*GP*(8AZ)P*GP*AP*GP*GP*GP*CP* UP*CP*UP*GP*AP*UP*AP*GP*CP*UP*AP*CP*G)-3), RNA(5-R(*CP*GP*UP*AP*GP*CP*UP*AP*UP*CP*AP*GP*AP*GP*CP*CP*CP*CP*CP*CP*GP*GP*CP*AP*UP*CP*GP*CP*GP*AP*GP*C)-3), ... (6 entities in total)
• Functional Keywords: protein-rna complex, rna editing, rna binding protein, rna binding protein-rna complex, rna binding protein/rna
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 130014.66

Authors

Wilcox, X.E.,Fisher, A.J.,Beal, P.A. (deposition date: 2022-08-09, release date: 2022-10-26, Last modification date: 2023-10-18)

• Primary citation: Doherty, E.E.,Karki, A.,Wilcox, X.E.,Mendoza, H.G.,Manjunath, A.,Matos, V.J.,Fisher, A.J.,Beal, P.A.; ADAR activation by inducing a syn conformation at guanosine adjacent to an editing site.; Nucleic Acids Res., 50:10857-10868, 2022; PubMed: 36243986; DOI: 10.1093/nar/gkac897

Experimental method

X-RAY DIFFRACTION (2.7 Å)