Human Carbonic Anhydrase II complexed with Althiazide

Summary for 3L14

DescriptorCarbonic anhydrase 2, ZINC ION, 4-AMINO-6-CHLOROBENZENE-1,3-DISULFONAMIDE, ... (4 entities in total)
Functional Keywords2, lyase, carbonic anhydrase ii, althiazide, 6-chloro-3, 4-dihydro-3-((2-propenylthio)methyl)-2h-1, 4-benzothiadiazine-7-sulfonamide, disease mutation, metal-binding
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm P00918
Total number of polymer chains1
Total molecular weight29640.2
Quirit, J.G.,Robbins, A.,Genis, C.,Tu, C.,Silverman, D.N.,McKenna, R. (deposition date: 2009-12-10, release date: 2011-01-05, Last modification date: 2011-07-13)
Primary citation
Quirit, J.G.,Robbins, A.,Rocca, J.R.,Johnson, J.,Genis, C.,Tu, C.,Silverman, D.N.,McKenna, R.
The Promiscuous Nature of Althiazide in Adducts with CA II and CA IX Mimic
To be Published,
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers60 2.3% 6.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-11-25