3L14

Human Carbonic Anhydrase II complexed with Althiazide

Summary for 3L14

DescriptorCarbonic anhydrase 2, ZINC ION, 4-AMINO-6-CHLOROBENZENE-1,3-DISULFONAMIDE, ... (4 entities in total)
Functional Keywords2, lyase, carbonic anhydrase ii, althiazide, 6-chloro-3, 4-dihydro-3-((2-propenylthio)methyl)-2h-1, 4-benzothiadiazine-7-sulfonamide, disease mutation, metal-binding
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm P00918
Total number of polymer chains1
Total molecular weight29640.2
Authors
Quirit, J.G.,Robbins, A.,Genis, C.,Tu, C.,Silverman, D.N.,McKenna, R. (deposition date: 2009-12-10, release date: 2011-01-05, Last modification date: 2011-07-13)
Primary citation
Quirit, J.G.,Robbins, A.,Rocca, J.R.,Johnson, J.,Genis, C.,Tu, C.,Silverman, D.N.,McKenna, R.
The Promiscuous Nature of Althiazide in Adducts with CA II and CA IX Mimic
To be Published,
Experimental method
X-RAY DIFFRACTION (1.22 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers60 2.3% 6.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
171588
PDB entries from 2020-11-25