PDB: 9760 件ウェブページステータス検索Chemie searchBIRD

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6EHV	scFv AbVance: increasing our knowledge of antibody structural space to enable faster and better decision making in drug discovery 分子名称: scFv AbVance: increasing our knowledge of antibody structural space to enable faster and better decision making in drug discovery 著者 Hargreaves, D. 登録日 2017-09-15 公開日 2017-11-08 最終更新日 2019-10-16 実験手法 X-RAY DIFFRACTION (2.54 Å) 主引用文献 scFv AbVance: increasing our knowledge of antibody structural space to enable faster and better decision making in drug discovery To Be Published
7TI6	Crystal structure of the wild-type least mutated common ancestor (LMCA) of the HIV-targeting PCT64 antibody lineage 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, PCT64_LMCA Fab heavy chain, PCT64_LMCA light chain (wild type) 著者 Omorodion, O, Wilson, I.A. 登録日 2022-01-12 公開日 2022-10-05 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.64 Å) 主引用文献 Human immunoglobulin repertoire analysis guides design of vaccine priming immunogens targeting HIV V2-apex broadly neutralizing antibody precursors. Immunity, 55, 2022
6EHW	scFv AbVance: increasing our knowledge of antibody structural space to enable faster and better decision making in drug discovery 分子名称: scFv AbVance: increasing our knowledge of antibody structural space to enable faster and better decision making in drug discovery 著者 Hargreaves, D. 登録日 2017-09-15 公開日 2017-11-08 最終更新日 2019-10-16 実験手法 X-RAY DIFFRACTION (2.19 Å) 主引用文献 scFv AbVance: increasing our knowledge of antibody structural space to enable faster and better decision making in drug discovery To Be Published
7X94	The SARS-CoV-2 receptor binding domain bound with the Fab fragment of a human neutralizing antibody Ab712 分子名称: Ab712 heavy chain, Ab712 light chain, Spike glycoprotein, ... 著者 Kamada, K, Shirouzu, M. 登録日 2022-03-15 公開日 2023-03-22 最終更新日 2023-09-13 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Potent neutralizing broad-spectrum antibody against SARS-CoV-2 generated from dual-antigen-specific B cells from convalescents. Iscience, 26, 2023
7X96	The SARS-CoV-2 receptor binding domain bound with the Fab fragment of a human neutralizing antibody Ab847 分子名称: Ab847 heavy chain, Ab847 light chain, Spike glycoprotein, ... 著者 Kamada, K, Shirouzu, M. 登録日 2022-03-15 公開日 2023-03-22 最終更新日 2023-09-13 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Potent neutralizing broad-spectrum antibody against SARS-CoV-2 generated from dual-antigen-specific B cells from convalescents. Iscience, 26, 2023
4LHJ	Ricin A chain bound to camelid nanobody (VHH5) 分子名称: CHLORIDE ION, Camelid antibody, Ricin 著者 Rudolph, M.J, Cheung, J, Franklin, M, Burshteyn, F, Cassidy, M, Gary, E, Mantis, N. 登録日 2013-07-01 公開日 2014-06-11 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal Structures of Ricin Toxin's Enzymatic Subunit (RTA) in Complex with Neutralizing and Non-Neutralizing Single-Chain Antibodies. J.Mol.Biol., 426, 2014
4ZS7	Structural mimicry of receptor interaction by antagonistic IL-6 antibodies 分子名称: Interleukin-6, Llama Fab fragment 68F2 heavy chain, Llama Fab fragment 68F2 light chain 著者 Blanchetot, C, De Jonge, N, Desmyter, A, Ongenae, N, Hofman, E, Klarenbeek, A, Sadi, A, Hultberg, A, Kretz-Rommel, A, Spinelli, S, Loris, R, Cambillau, C, de Haard, H. 登録日 2015-05-13 公開日 2016-05-04 最終更新日 2016-07-06 実験手法 X-RAY DIFFRACTION (2.93 Å) 主引用文献 Structural Mimicry of Receptor Interaction by Antagonistic Interleukin-6 (IL-6) Antibodies. J.Biol.Chem., 291, 2016
6EHX	scFv AbVance: increasing our knowledge of antibody structural space to enable faster and better decision making in drug discovery 分子名称: scFv AbVance: increasing our knowledge of antibody structural space to enable faster and better decision making in drug discovery 著者 Hargreaves, D. 登録日 2017-09-15 公開日 2017-11-08 最終更新日 2019-10-16 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 scFv AbVance: increasing our knowledge of antibody structural space to enable faster and better decision making in drug discovery To Be Published
6APB	Crystal Structure of Non-Neutralizing Infant Antibody ADI-14359 in Complex with Postfusion RSV F Glycoprotein 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ADI-14359 Fab Light Chain, Fusion glycoprotein F0,Fusion glycoprotein F0, ... 著者 Gilman, M.S.A, McLellan, J.S. 登録日 2017-08-17 公開日 2018-03-21 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Infants Infected with Respiratory Syncytial Virus Generate Potent Neutralizing Antibodies that Lack Somatic Hypermutation. Immunity, 48, 2018
6P8N	Crystal Structure of Antibody P-p1f1 in Complex with eOD-GT8 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, AMMONIUM ION, ... 著者 Weidle, C, Pancera, M. 登録日 2019-06-07 公開日 2019-11-20 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.202 Å) 主引用文献 Overcoming Steric Restrictions of VRC01 HIV-1 Neutralizing Antibodies through Immunization. Cell Rep, 29, 2019
7N5H	Cryo-EM structure of broadly neutralizing antibody 2-36 in complex with prefusion SARS-CoV-2 spike glycoprotein 分子名称: 2-36 Fab heavy chain, 2-36 Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Casner, R.G, Cerutti, G, Shapiro, L. 登録日 2021-06-05 公開日 2021-11-03 最終更新日 2022-11-16 実験手法 ELECTRON MICROSCOPY (3.24 Å) 主引用文献 A monoclonal antibody that neutralizes SARS-CoV-2 variants, SARS-CoV, and other sarbecoviruses. Emerg Microbes Infect, 11, 2022
8EK1	Cryo-EM structure of a potent anti-malarial antibody L9 in complex with Plasmodium falciparum circumsporozoite protein (PfCSP)(dominant class) 分子名称: Circumsporozoite protein, L9 Fab heavy chain, L9 Fab light chain 著者 Tripathi, P, Kwong, P.D. 登録日 2022-09-19 公開日 2023-03-15 最終更新日 2023-09-27 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Cryo-EM structures of anti-malarial antibody L9 with circumsporozoite protein reveal trimeric L9 association and complete 27-residue epitope. Structure, 31, 2023
6U6O	Crystal structure of a vaccine-elicited anti-HIV-1 rhesus macaque antibody DH846 分子名称: DH846 Fab heavy chain, DH846 Fab light chain 著者 Chen, W.-H, Choe, M, Saunders, K.O, Joyce, M.G. 登録日 2019-08-30 公開日 2021-03-24 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.806 Å) 主引用文献 Structural and genetic convergence of HIV-1 neutralizing antibodies in vaccinated non-human primates. Plos Pathog., 17, 2021
6U6M	Crystal structure of a vaccine-elicited anti-HIV-1 rhesus macaque antibody DH840.1 分子名称: DH840.1 Fab heavy chain, DH840.1 Fab light chain 著者 Chen, W.-H, Choe, M, Saunders, K.O, Joyce, M.G. 登録日 2019-08-30 公開日 2021-03-24 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.683 Å) 主引用文献 Structural and genetic convergence of HIV-1 neutralizing antibodies in vaccinated non-human primates. Plos Pathog., 17, 2021
7S5P	Crystal structure of SARS-CoV-2 B.1.351 variant receptor binding domain in complex with neutralizing antibody CS23 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CS23 Heavy chain, ... 著者 Yuan, M, Wilson, I.A. 登録日 2021-09-11 公開日 2022-03-09 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.86 Å) 主引用文献 SARS-CoV-2 Beta variant infection elicits potent lineage-specific and cross-reactive antibodies. Science, 375, 2022
7RYV	Anti-HIV neutralizing antibody Ab1573 Fab isolated from sequentially immunized macaques 分子名称: Ab1573 Fab heavy chain, Ab1573 Fab light chain 著者 Yang, Z, Bjorkman, P.J. 登録日 2021-08-26 公開日 2022-01-19 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Neutralizing antibodies induced in immunized macaques recognize the CD4-binding site on an occluded-open HIV-1 envelope trimer. Nat Commun, 13, 2022
7RYU	Anti-HIV neutralizing antibody Ab1303 Fab isolated from sequentially immunized mcaques 分子名称: Ab1303 Fab heavy chain, Ab1303 Fab light chain 著者 Yang, Z, Bjorkman, P.J. 登録日 2021-08-26 公開日 2022-01-19 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.51 Å) 主引用文献 Neutralizing antibodies induced in immunized macaques recognize the CD4-binding site on an occluded-open HIV-1 envelope trimer. Nat Commun, 13, 2022
6APC	Crystal Structure of Infant Antibody ADI-19425 分子名称: Epididymis luminal protein 214, IGL@ protein, SULFATE ION 著者 Gilman, M.S.A, McLellan, J.S. 登録日 2017-08-17 公開日 2018-03-21 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Infants Infected with Respiratory Syncytial Virus Generate Potent Neutralizing Antibodies that Lack Somatic Hypermutation. Immunity, 48, 2018
6APD	Crystal structure of RSV F bound by AM22 and the infant antibody ADI-19425 分子名称: AM22 Fab Heavy Chain,IGH@ protein, AM22 Fab Light Chain,Uncharacterized protein, Fusion glycoprotein F0,Envelope glycoprotein, ... 著者 Wrapp, D, McLellan, J.S. 登録日 2017-08-17 公開日 2018-03-21 最終更新日 2020-01-01 実験手法 X-RAY DIFFRACTION (4.1 Å) 主引用文献 Infants Infected with Respiratory Syncytial Virus Generate Potent Neutralizing Antibodies that Lack Somatic Hypermutation. Immunity, 48, 2018
8F2J	Crystal structure of antibody WRAIR-2134 in complex with SARS-CoV-2 receptor binding domain 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, ... 著者 Sankhala, R.S, Joyce, M.G. 登録日 2022-11-08 公開日 2023-12-13 実験手法 X-RAY DIFFRACTION (3.16 Å) 主引用文献 Antibody Targeting of Conserved Sites of Vulnerability on the SARS-CoV-2 Spike Receptor-Binding Domain. To Be Published
8F2X	Crystal structure of antibody WRAIR-2123 in complex with SARS-CoV-2 receptor binding domain 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, WRAIR-2123 Fab Heavy chain, ... 著者 Sankhala, R.S, Joyce, G.M. 登録日 2022-11-08 公開日 2024-04-17 実験手法 X-RAY DIFFRACTION (3.501 Å) 主引用文献 Antibody Targeting of Conserved Sites of Vulnerability on the SARS-CoV-2 Spike Receptor-Binding Domain To Be Published
7MF1	Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody 47D1 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 47D1 Fab heavy chain, ... 著者 Yuan, M, Zhu, X, Wilson, I.A. 登録日 2021-04-08 公開日 2021-05-12 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.092 Å) 主引用文献 Diverse immunoglobulin gene usage and convergent epitope targeting in neutralizing antibody responses to SARS-CoV-2. Cell Rep, 35, 2021
7NX6	Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with COVOX-222 and EY6A Fabs 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, COVOX-222 Fab Heavy chain, ... 著者 Zhou, D, Ren, J, Stuart, D. 登録日 2021-03-17 公開日 2021-04-07 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Antibody evasion by the P.1 strain of SARS-CoV-2. Cell, 184, 2021
7NXA	Crystal structure of the receptor binding domain of SARS-CoV-2 B.1.351 variant Spike glycoprotein in complex with COVOX-222 and EY6A Fabs 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, COVOX-222 Fab heavy chain, COVOX-222 Fab light chain, ... 著者 Zhou, D, Ren, J, Stuart, D. 登録日 2021-03-17 公開日 2021-04-07 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Antibody evasion by the P.1 strain of SARS-CoV-2. Cell, 184, 2021
7NX7	Crystal structure of the K417N mutant receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with COVOX-222 and EY6A Fabs 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, CITRIC ACID, ... 著者 Zhou, D, Ren, J, Stuart, D. 登録日 2021-03-17 公開日 2021-04-07 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Antibody evasion by the P.1 strain of SARS-CoV-2. Cell, 184, 2021

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