PDB: 46006 件ウェブページステータス検索Chemie searchBIRD

---

8CVT	Human 19S-20S proteasome, state SD2 分子名称: 26S protease regulatory subunit 10B, 26S protease regulatory subunit 8, 26S proteasome complex subunit SEM1, ... 著者 Zhao, J. 登録日 2022-05-18 公開日 2022-11-02 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural insights into the human PA28-20S proteasome enabled by efficient tagging and purification of endogenous proteins. Proc.Natl.Acad.Sci.USA, 119, 2022
5FLX	Mammalian 40S HCV-IRES complex 分子名称: 18S RRNA, 40S RIBOSOMAL PROTEIN S10, 40S RIBOSOMAL PROTEIN S11, ... 著者 Yamamoto, H, Collier, M, Loerke, J, Ismer, J, Schmidt, A, Hilal, T, Sprink, T, Yamamoto, K, Mielke, T, Burger, J, Shaikh, T.R, Dabrowski, M, Hildebrand, P.W, Scheerer, P, Spahn, C.M.T. 登録日 2015-10-28 公開日 2015-12-23 最終更新日 2017-08-30 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Molecular Architecture of the Ribosome-Bound Hepatitis C Virus Internal Ribosomal Entry Site RNA. Embo J., 34, 2015
8RU8	A crystal form of a human CDK2-CDK7 chimera 分子名称: (3R,4R)-4-[[[7-[(phenylmethyl)amino]-3-propan-2-yl-pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol, Cyclin-dependent kinase 2 著者 Mukherjee, M, Cleasby, A. 登録日 2024-01-30 公開日 2024-06-26 最終更新日 2024-08-21 実験手法 X-RAY DIFFRACTION (1.51 Å) 主引用文献 Protein engineering enables a soakable crystal form of human CDK7 primed for high-throughput crystallography and structure-based drug design. Structure, 32, 2024
5H6X	The crystal structure of RpoS fragment including a partial region 1.2 and region 2 from intracellular pathogen Legionella pneumophila 分子名称: GLYCEROL, RNA polymerase sigma factor RpoS, SODIUM ION 著者 Zhang, N, Chen, X, Gong, X, Ge, H. 登録日 2016-11-15 公開日 2017-11-22 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 High-Resolution Crystal Structure of RpoS Fragment including a Partial Region 1.2 and Region 2 from the Intracellular Pathogen Legionella pneumophila Crystals, 8, 2018
5UQ1	Crystal structure of human Cdk2-Spy1 complex 分子名称: Cyclin-dependent kinase 2, Speedy protein A 著者 McGrath, D.A, Tripathi, S.M, Rubin, S.M. 登録日 2017-02-06 公開日 2017-07-05 最終更新日 2017-08-09 実験手法 X-RAY DIFFRACTION (3.201 Å) 主引用文献 Structural basis of divergent cyclin-dependent kinase activation by Spy1/RINGO proteins. EMBO J., 36, 2017
5GJQ	Structure of the human 26S proteasome bound to USP14-UbAl 分子名称: 26S protease regulatory subunit 10B, 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, ... 著者 Huang, X.L, Luan, B, Wu, J.P, Shi, Y.G. 登録日 2016-07-01 公開日 2016-08-17 最終更新日 2019-11-06 実験手法 ELECTRON MICROSCOPY (4.5 Å) 主引用文献 An atomic structure of the human 26S proteasome. Nat. Struct. Mol. Biol., 23, 2016
2YKM	Crystal structure of HIV-1 Reverse Transcriptase (RT) in complex with a Difluoromethylbenzoxazole (DFMB) Pyrimidine Thioether derivative, a non-nucleoside RT inhibitor (NNRTI) 分子名称: 2-[DIFLUORO-[(4-METHYL-PYRIMIDINYL)-THIO]METHYL]-BENZOXAZOLE, CALCIUM ION, REVERSE TRANSCRIPTASE/RIBONUCLEASE H 著者 Boyer, J, Arnoult, E, Medebielle, M, Guillemont, J, Unge, T, Unge, J, Jochmans, D. 登録日 2011-05-28 公開日 2011-08-17 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Difluoromethylbenzoxazole Pyrimidine Thioether Derivatives: A Novel Class of Potent Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors. J.Med.Chem., 54, 2011
3FK7	Crystal structure of TetR triple mutant (H64K, S135L, S138I) in complex with 4-ddma-atc 分子名称: (4aS,12aS)-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-1,4,4a,5,12,12a-hexahydrotetracene-2-carboxamide, MAGNESIUM ION, Tetracycline repressor protein class B from transposon Tn10, ... 著者 Klieber, M.A, Scholz, O, Lochner, S, Gmeiner, P, Hillen, W, Muller, Y.A. 登録日 2008-12-16 公開日 2009-11-03 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 Structural origins for selectivity and specificity in an engineered bacterial repressor-inducer pair. Febs J., 276, 2009
5UQ2	Crystal structure of human Cdk2-Spy1 complex 分子名称: Cyclin-dependent kinase 2, Speedy protein A 著者 McGrath, D.A, Tripathi, S.M, Rubin, S.M. 登録日 2017-02-06 公開日 2017-07-05 最終更新日 2017-08-09 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural basis of divergent cyclin-dependent kinase activation by Spy1/RINGO proteins. EMBO J., 36, 2017
2YKN	Crystal structure of HIV-1 Reverse Transcriptase (RT) in complex with a Difluoromethylbenzoxazole (DFMB) Pyrimidine Thioether derivative, a non-nucleoside RT inhibitor (NNRTI) 分子名称: 2-[DIFLUORO-[(4-METHYL-PYRIMIDINYL)-THIO]METHYL]-BENZOXAZOLE, CALCIUM ION, REVERSE TRANSCRIPTASE/RIBONUCLEASE H 著者 Boyer, J, Arnoult, E, Medebielle, M, Guillemont, J, Unge, T, Unge, J, Jochmans, D. 登録日 2011-05-28 公開日 2011-08-17 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.12 Å) 主引用文献 Difluoromethylbenzoxazole Pyrimidine Thioether Derivatives: A Novel Class of Potent Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors. J.Med.Chem., 54, 2011
4I80	Crystal structure of human menin in complex with a high-affinity macrocyclic peptidomimetics 分子名称: Menin, macrocyclic peptidomimetic 著者 Huang, J, Lei, M. 登録日 2012-12-01 公開日 2013-03-06 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structure-Based Design of High-Affinity Macrocyclic Peptidomimetics to Block the Menin-Mixed Lineage Leukemia 1 (MLL1) Protein-Protein Interaction. J.Med.Chem., 56, 2013
2IA2	The crystal structure of a putative transcriptional regulator RHA06195 from Rhodococcus sp. RHA1 分子名称: Putative Transcriptional Regulator 著者 Cymborowski, M.T, Chruszcz, M, Skarina, T, Onopriyenko, O, Savchenko, A, Edwards, A, Joachimiak, A, Minor, W, Midwest Center for Structural Genomics (MCSG) 登録日 2006-09-06 公開日 2006-10-10 最終更新日 2022-04-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The crystal structure of a putative transcriptional regulator RHA06195 from Rhodococcus sp. RHA1 To be Published
3MZ3	Crystal structure of Co2+ HDAC8 complexed with M344 分子名称: 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, COBALT (II) ION, Histone deacetylase 8, ... 著者 Dowling, D.P, Gattis, S.G, Fierke, C.A, Christianson, D.W. 登録日 2010-05-11 公開日 2010-06-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structures of metal-substituted human histone deacetylase 8 provide mechanistic inferences on biological function. Biochemistry, 49, 2010
1JMV	Structure of Haemophylus influenzae Universal Stress Protein At 1.85A Resolution 分子名称: SULFATE ION, Universal Stress Protein A 著者 Sousa, M.C, McKay, D.B. 登録日 2001-07-20 公開日 2001-12-12 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structure of the universal stress protein of Haemophilus influenzae. Structure, 9, 2001
1JN7	Solution Structure of a CCHH mutant of the ninth CCHC Zinc Finger of U-shaped 分子名称: U-shaped TRANSCRIPTIONAL COFACTOR, ZINC ION 著者 Kowalski, K, Mackay, J.P. 登録日 2001-07-23 公開日 2002-09-25 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Characterization of the Conserved Interaction between GATA and FOG Family Proteins J.Biol.Chem., 277, 2002
2ION	Crystal structure of the C-terminal MA3 domain of Pdcd4 (mouse); form2 分子名称: GLYCEROL, Programmed Cell Death 4, Pdcd4 著者 Wlodawer, A, LaRonde-LeBlanc, N.A. 登録日 2006-10-10 公開日 2006-11-14 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.57 Å) 主引用文献 Structural basis for inhibition of translation by the tumor suppressor pdcd4. Mol.Cell.Biol., 27, 2007
2IOL	Crystal structure of the C-terminal MA3 domain of Pdcd4 (mouse); form 1 分子名称: Programmed Cell Death 4, Pdcd4 著者 Wlodawer, A, LaRonde-LeBlanc, N.A. 登録日 2006-10-10 公開日 2006-11-14 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural basis for inhibition of translation by the tumor suppressor pdcd4. Mol.Cell.Biol., 27, 2007
3NDQ	Structure of Human TFIIS Domain II 分子名称: SODIUM ION, Transcription elongation factor A protein 1 著者 Hu, X.P, Averell, G, Ye, X.Y, Hou, J, Luo, H. 登録日 2010-06-07 公開日 2011-05-18 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.933 Å) 主引用文献 Structure of Human TFIIS Domain II To be Published
8HKS	Mutated human ADP-ribosyltransferase 2 (PARP2) catalytic domain bound to Pamiparib(BGB-290) 分子名称: (2R)-14-fluoro-2-methyl-6,9,10,19-tetrazapentacyclo[14.2.1.02,6.08,18.012,17]nonadeca-1(18),8,12(17),13,15-pentaen-11-one, GLYCEROL, Poly [ADP-ribose] polymerase 2 著者 Wang, X.Y, Zhou, J, Xu, B.L. 登録日 2022-11-28 公開日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Mutated human ADP-ribosyltransferase 2 (PARP2) catalytic domain bound to Pamiparib To Be Published
3N6L	The crystal structure of RNA-dependent RNA polymerase of EV71 virus 分子名称: NICKEL (II) ION, RNA-dependent RNA polymerase 著者 Wu, Y, Rao, Z.H. 登録日 2010-05-26 公開日 2011-06-15 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China. Protein Cell, 1, 2010
8HKN	Mutated human ADP-ribosyltransferase 2 (PARP2) catalytic domain bound to approved drug Fluzoparib 分子名称: Fluzoparib, GLYCEROL, Poly [ADP-ribose] polymerase 2 著者 Wang, X.Y, Zhou, J, Xu, B.L. 登録日 2022-11-27 公開日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Mutated human ADP-ribosyltransferase 2 (PARP2) catalytic domain bound to approved drug Fluzoparib To Be Published
8HKO	Mutated human ADP-ribosyltransferase 2 (PARP2) catalytic domain bound to Rucaparib 分子名称: GLYCEROL, Poly [ADP-ribose] polymerase 2, Rucaparib 著者 Wang, X.Y, Zhou, J, Xu, B.L. 登録日 2022-11-27 公開日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Mutated human ADP-ribosyltransferase 2 (PARP2) catalytic domain bound to Rucaparib To Be Published
8HLQ	Mutated human ADP-ribosyltransferase 2 (PARP2) catalytic domain bound to Niraparib (MK-4827) 分子名称: 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide, GLYCEROL, Poly [ADP-ribose] polymerase 2 著者 Wang, X.Y, Zhou, J, Xu, B.L. 登録日 2022-11-30 公開日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Mutated human ADP-ribosyltransferase 2 (PARP2) catalytic domain bound to Niraparib (MK-4827) To Be Published
8HLJ	Mutated human ADP-ribosyltransferase 2 (PARP2) catalytic domain bound to Olaparib (AZD2281) 分子名称: 4-(3-{[4-(cyclopropylcarbonyl)piperazin-1-yl]carbonyl}-4-fluorobenzyl)phthalazin-1(2H)-one, Poly [ADP-ribose] polymerase 2 著者 Wang, X.Y, Zhou, J, Xu, B.L. 登録日 2022-11-30 公開日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.24 Å) 主引用文献 Mutated human ADP-ribosyltransferase 2 (PARP2) catalytic domain bound to Olaparib (AZD2281) To Be Published
2ILZ	Crystal structure of poliovirus polymerase complexed with GTP and Mn2+ 分子名称: ACETIC ACID, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ... 著者 Thompson, A.A, Peersen, O.B. 登録日 2006-10-03 公開日 2006-12-12 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Stabilization of Poliovirus Polymerase by NTP Binding and Fingers-Thumb Interactions. J.Mol.Biol., 366, 2007

<925926927928929930931932933934935936937938939940>