8RU8

A crystal form of a human CDK2-CDK7 chimera

Summary for 8RU8

Entry DOI	10.2210/pdb8ru8/pdb
Descriptor	Cyclin-dependent kinase 2, (3R,4R)-4-[[[7-[(phenylmethyl)amino]-3-propan-2-yl-pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol (3 entities in total)
Functional Keywords	cyclin dependent kinase 7, serine/threonine kinase, atp binding, cell cycle kinase, signaling protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	35166.86
Authors	Mukherjee, M.,Cleasby, A. (deposition date: 2024-01-30, release date: 2024-06-26)
Primary citation	Mukherjee, M.,Day, P.J.,Laverty, D.,Bueren-Calabuig, J.A.,Woodhead, A.J.,Griffiths-Jones, C.,Hiscock, S.,East, C.,Boyd, S.,O'Reilly, M. Protein engineering enables a soakable crystal form of human CDK7 primed for high-throughput crystallography and structure-based drug design. Structure, 2024 Cited by PubMed: 38870939 DOI: 10.1016/j.str.2024.05.011 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.51 Å)

Structure validation