8RU8

A crystal form of a human CDK2-CDK7 chimera

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Cyclin-dependent kinase 2	polymer	306	34772.4	1	UniProt (P24941) Pfam (PF00069) In PDB	Homo sapiens (human)	Cell division protein kinase 2,p33 protein kinase
2	A	(3R,4R)-4-[[[7-[(phenylmethyl)amino]-3-propan-2-yl-pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol	non-polymer		394.5	1	Chemie (I74)
3		water	water		18.0	290	Chemie (HOH)

Sequence modifications

A: 1 - 298 (UniProt: P24941)

PDB	External Database	Details
Gly -7	-	expression tag
Pro -6	-	expression tag
Leu -5	-	expression tag
Gly -4	-	expression tag
Ser -3	-	expression tag
Pro -2	-	expression tag
Glu -1	-	expression tag
Phe 0	-	expression tag
Leu 10	Ile 10	engineered mutation
Gln 14	Thr 14	engineered mutation
Ile 64	Val 64	engineered mutation
Glu 88	Lys 88	engineered mutation
Val 89	Lys 89	engineered mutation
Lys 92	Asp 92	engineered mutation
Asn 131	Gln 131	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	34772.4
Non-Polymers*	Number of molecules	1
	Total formula weight	394.5
All*	Total formula weight	35166.9

*Water molecules are not included.