8RU8
A crystal form of a human CDK2-CDK7 chimera
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cyclin-dependent kinase 2 | polymer | 306 | 34772.4 | 1 | UniProt (P24941) Pfam (PF00069) | Homo sapiens (human) | Cell division protein kinase 2,p33 protein kinase |
| 2 | B (A) | (3R,4R)-4-[[[7-[(phenylmethyl)amino]-3-propan-2-yl-pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol | non-polymer | 394.5 | 1 | Chemie (I74) | |||
| 3 | C (A) | water | water | 18.0 | 290 | Chemie (HOH) |
Sequence modifications
A: 1 - 298 (UniProt: P24941)
| PDB | External Database | Details |
|---|---|---|
| Gly -7 | - | expression tag |
| Pro -6 | - | expression tag |
| Leu -5 | - | expression tag |
| Gly -4 | - | expression tag |
| Ser -3 | - | expression tag |
| Pro -2 | - | expression tag |
| Glu -1 | - | expression tag |
| Phe 0 | - | expression tag |
| Leu 10 | Ile 10 | engineered mutation |
| Gln 14 | Thr 14 | engineered mutation |
| Ile 64 | Val 64 | engineered mutation |
| Glu 88 | Lys 88 | engineered mutation |
| Val 89 | Lys 89 | engineered mutation |
| Lys 92 | Asp 92 | engineered mutation |
| Asn 131 | Gln 131 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34772.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 394.5 | |
| All* | Total formula weight | 35166.9 |
