8RU8
A crystal form of a human CDK2-CDK7 chimera
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Cyclin-dependent kinase 2 | polymer | 306 | 34772.4 | 1 | UniProt (P24941) Pfam (PF00069) In PDB | Homo sapiens (human) | Cell division protein kinase 2,p33 protein kinase |
2 | A | (3R,4R)-4-[[[7-[(phenylmethyl)amino]-3-propan-2-yl-pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol | non-polymer | 394.5 | 1 | Chemie (I74) | |||
3 | water | water | 18.0 | 290 | Chemie (HOH) |
Sequence modifications
A: 1 - 298 (UniProt: P24941)
PDB | External Database | Details |
---|---|---|
Gly -7 | - | expression tag |
Pro -6 | - | expression tag |
Leu -5 | - | expression tag |
Gly -4 | - | expression tag |
Ser -3 | - | expression tag |
Pro -2 | - | expression tag |
Glu -1 | - | expression tag |
Phe 0 | - | expression tag |
Leu 10 | Ile 10 | engineered mutation |
Gln 14 | Thr 14 | engineered mutation |
Ile 64 | Val 64 | engineered mutation |
Glu 88 | Lys 88 | engineered mutation |
Val 89 | Lys 89 | engineered mutation |
Lys 92 | Asp 92 | engineered mutation |
Asn 131 | Gln 131 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 34772.4 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 394.5 | |
All* | Total formula weight | 35166.9 |