8OU6
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![BU of 8ou6 by Molmil](/molmil-images/mine/8ou6) | Cereblon isoform 4 in complex with novel Benzamide-Type Cereblon Binder 11c | 分子名称: | 4-azanyl-~{N}-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-2-methyl-benzamide, Cereblon isoform 4, PHOSPHATE ION, ... | 著者 | Heim, C, Bischof, L, Hartmann, M.D. | 登録日 | 2023-04-21 | 公開日 | 2023-11-15 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs. J.Med.Chem., 66, 2023
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8OVU
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![BU of 8ovu by Molmil](/molmil-images/mine/8ovu) | Human titin immunoglobulin-like 21 domain | 分子名称: | MAGNESIUM ION, Titin | 著者 | Martinez-Martin, I, Crousilles, A, Mortensen, S.A, Alegre-Cebollada, J, Wilmanns, M. | 登録日 | 2023-04-26 | 公開日 | 2023-11-29 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Titin domains with reduced core hydrophobicity cause dilated cardiomyopathy. Cell Rep, 42, 2023
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8OUA
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![BU of 8oua by Molmil](/molmil-images/mine/8oua) | Cereblon isoform 4 in complex with novel Benzamide-Type Cereblon Binder 11f | 分子名称: | 4-azanyl-~{N}-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-2,5-bis(fluoranyl)-3-methoxy-benzamide, Cereblon isoform 4, PHOSPHATE ION, ... | 著者 | Heim, C, Bischof, L, Hartmann, M.D. | 登録日 | 2023-04-22 | 公開日 | 2023-11-15 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs. J.Med.Chem., 66, 2023
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7SCJ
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1R81
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![BU of 1r81 by Molmil](/molmil-images/mine/1r81) | Glycosyltransferase A in complex with 3-amino-acceptor analog inhibitor and uridine diphosphate-N-acetyl-galactose | 分子名称: | Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase, MERCURY (II) ION, URIDINE-DIPHOSPHATE-N-ACETYLGALACTOSAMINE, ... | 著者 | Nguyen, H.P, Seto, N.O.L, Cai, Y, Leinala, E.K, Borisova, S.N, Palcic, M.M, Evans, S.V. | 登録日 | 2003-10-22 | 公開日 | 2004-02-10 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | The influence of an intramolecular hydrogen bond in differential recognition of inhibitory acceptor analogs by human ABO(H) blood group A and B glycosyltransferases J.Biol.Chem., 278, 2003
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8OL6
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![BU of 8ol6 by Molmil](/molmil-images/mine/8ol6) | Murine type II Abeta fibril from tgAPPSwe mouse | 分子名称: | Amyloid-beta protein 42 | 著者 | Zielinski, M, Peralta Reyes, F.S, Gremer, L, Schemmert, S, Frieg, B, Willuweit, A, Donner, L, Elvers, M, Nilsson, L.N.G, Syvanen, S, Sehlin, D, Ingelsson, M, Willbold, D, Schroeder, G.F. | 登録日 | 2023-03-30 | 公開日 | 2023-11-29 | 最終更新日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Cryo-EM of A beta fibrils from mouse models find tg-APP ArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease. Nat.Neurosci., 26, 2023
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7SCH
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![BU of 7sch by Molmil](/molmil-images/mine/7sch) | Cryo-EM structure of the human Exostosin-1 and Exostosin-2 heterodimer | 分子名称: | Exostosin-1, Exostosin-2, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Li, H, Li, H. | 登録日 | 2021-09-28 | 公開日 | 2022-09-28 | 最終更新日 | 2023-05-17 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural basis for heparan sulfate co-polymerase action by the EXT1-2 complex. Nat.Chem.Biol., 19, 2023
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7SAA
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8PC2
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![BU of 8pc2 by Molmil](/molmil-images/mine/8pc2) | SelDeg51 in complex with FKBP51FK1 domain and pVHL:EloB:EloC | 分子名称: | Elongin-B, Elongin-C, Peptidyl-prolyl cis-trans isomerase FKBP5, ... | 著者 | Meyners, C, Walz, M, Geiger, T.M, Hausch, F. | 登録日 | 2023-06-09 | 公開日 | 2023-11-15 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Discovery of a Potent Proteolysis Targeting Chimera Enables Targeting the Scaffolding Functions of FK506-Binding Protein 51 (FKBP51). Angew.Chem.Int.Ed.Engl., 63, 2024
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8P29
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![BU of 8p29 by Molmil](/molmil-images/mine/8p29) | TEAD2 in complex with an inhibitor | 分子名称: | 5-methyl-2-[(3-phenylmethoxyphenyl)amino]benzoic acid, GLYCEROL, MYRISTIC ACID, ... | 著者 | Guichou, J.F, Gelin, M, Allemand, F. | 登録日 | 2023-05-15 | 公開日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | 主引用文献 | Development of LM-41 and AF-2112, two flufenamic acid-derived TEAD inhibitors obtained through the replacement of the trifluoromethyl group by aryl rings. Bioorg.Med.Chem.Lett., 95, 2023
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8PDF
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![BU of 8pdf by Molmil](/molmil-images/mine/8pdf) | FKBP12 in complex with PROTAC 6a2 | 分子名称: | (2~{S},4~{R})-1-[(2~{S})-2-[2-[2-[2-[4-[(1~{S})-1-[(1~{S},5~{S},6~{R})-10-[3,5-bis(chloranyl)phenyl]sulfonyl-5-ethenyl-2-oxidanylidene-3,10-diazabicyclo[4.3.1]decan-3-yl]ethyl]-1,2,3-triazol-1-yl]ethoxy]ethoxy]ethanoylamino]-3,3-dimethyl-butanoyl]-~{N}-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Peptidyl-prolyl cis-trans isomerase FKBP1A | 著者 | Meyners, C, Walz, M, Geiger, T.M, Hausch, F. | 登録日 | 2023-06-12 | 公開日 | 2023-11-15 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Discovery of a Potent Proteolysis Targeting Chimera Enables Targeting the Scaffolding Functions of FK506-Binding Protein 51 (FKBP51). Angew.Chem.Int.Ed.Engl., 63, 2024
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6E18
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![BU of 6e18 by Molmil](/molmil-images/mine/6e18) | Crystal structure of Chlamydomonas reinhardtii HAP2 ectodomain provides structural insights of functional loops in green algae. | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... | 著者 | Baquero, E, Legrand, P, Rey, F.A. | 登録日 | 2018-07-09 | 公開日 | 2018-11-07 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Species-Specific Functional Regions of the Green Alga Gamete Fusion Protein HAP2 Revealed by Structural Studies. Structure, 27, 2019
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1A09
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8P81
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![BU of 8p81 by Molmil](/molmil-images/mine/8p81) | Crystal structure of human Cdk12/Cyclin K in complex with inhibitor SR-4835 | 分子名称: | Cyclin-K, Cyclin-dependent kinase 12, ~{N}-[[5,6-bis(chloranyl)-1~{H}-benzimidazol-2-yl]methyl]-9-(1-methylpyrazol-4-yl)-2-morpholin-4-yl-purin-6-amine | 著者 | Anand, K, Schmitz, M, Geyer, M. | 登録日 | 2023-05-31 | 公開日 | 2023-11-22 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | 主引用文献 | The reversible inhibitor SR-4835 binds Cdk12/cyclin K in a noncanonical G-loop conformation. J.Biol.Chem., 300, 2023
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8OLN
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![BU of 8oln by Molmil](/molmil-images/mine/8oln) | DI1 Abeta fibril from tg-SwDI mouse | 分子名称: | Amyloid-beta protein 42 | 著者 | Zielinski, M, Peralta Reyes, F.S, Gremer, L, Schemmert, S, Frieg, B, Willuweit, A, Donner, L, Elvers, M, Nilsson, L.N.G, Syvanen, S, Sehlin, D, Ingelsson, M, Willbold, D, Schroeder, G.F. | 登録日 | 2023-03-30 | 公開日 | 2023-11-29 | 最終更新日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Cryo-EM of A beta fibrils from mouse models find tg-APP ArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease. Nat.Neurosci., 26, 2023
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6OA7
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![BU of 6oa7 by Molmil](/molmil-images/mine/6oa7) | Horse liver L57F alcohol dehydrogenase E complexed with NAD and trifluoroethanol | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, Alcohol dehydrogenase E chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE (ACIDIC FORM), ... | 著者 | Plapp, B.V. | 登録日 | 2019-03-15 | 公開日 | 2019-04-03 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | Substitutions of Amino Acid Residues in the Substrate Binding Site of Horse Liver Alcohol Dehydrogenase Have Small Effects on the Structures but Significantly Affect Catalysis of Hydrogen Transfer. Biochemistry, 59, 2020
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1A1E
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8OLQ
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![BU of 8olq by Molmil](/molmil-images/mine/8olq) | DI3 Abeta fibril from tg-SwDI mouse | 分子名称: | Amyloid-beta protein 42 | 著者 | Zielinski, M, Peralta Reyes, F.S, Gremer, L, Schemmert, S, Frieg, B, Willuweit, A, Donner, L, Elvers, M, Nilsson, L.N.G, Syvanen, S, Sehlin, D, Ingelsson, M, Willbold, D, Schroeder, G.F. | 登録日 | 2023-03-30 | 公開日 | 2023-11-29 | 最終更新日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Cryo-EM of A beta fibrils from mouse models find tg-APP ArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease. Nat.Neurosci., 26, 2023
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8OL3
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![BU of 8ol3 by Molmil](/molmil-images/mine/8ol3) | Murine type III Abeta fibril from APP/PS1 mouse | 分子名称: | Amyloid-beta protein 42 | 著者 | Zielinski, M, Peralta Reyes, F.S, Gremer, L, Schemmert, S, Frieg, B, Willuweit, A, Donner, L, Elvers, M, Nilsson, L.N.G, Syvanen, S, Sehlin, D, Ingelsson, M, Willbold, D, Schroeder, G.F. | 登録日 | 2023-03-30 | 公開日 | 2023-11-29 | 最終更新日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Cryo-EM of A beta fibrils from mouse models find tg-APP ArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease. Nat.Neurosci., 26, 2023
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8P35
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![BU of 8p35 by Molmil](/molmil-images/mine/8p35) | Mutant human titin immunoglobulin-like 21 domain - C3575S | 分子名称: | Titin | 著者 | Martinez-Martin, I, Crousilles, A, Mortensen, S.A, Alegre-Cebollada, J, Wilmanns, M. | 登録日 | 2023-05-17 | 公開日 | 2023-11-29 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Titin domains with reduced core hydrophobicity cause dilated cardiomyopathy. Cell Rep, 42, 2023
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8P49
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8OQH
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8OL2
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![BU of 8ol2 by Molmil](/molmil-images/mine/8ol2) | Murine type II Abeta fibril from APP23 mouse | 分子名称: | Amyloid-beta protein 42 | 著者 | Zielinski, M, Peralta Reyes, F.S, Gremer, L, Schemmert, S, Frieg, B, Willuweit, A, Donner, L, Elvers, M, Nilsson, L.N.G, Syvanen, S, Sehlin, D, Ingelsson, M, Willbold, D, Schroeder, G.F. | 登録日 | 2023-03-30 | 公開日 | 2023-11-29 | 最終更新日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Cryo-EM of A beta fibrils from mouse models find tg-APP ArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease. Nat.Neurosci., 26, 2023
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8OL5
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![BU of 8ol5 by Molmil](/molmil-images/mine/8ol5) | Murine type II Abeta fibril from ARTE10 mouse | 分子名称: | Amyloid-beta protein 42 | 著者 | Zielinski, M, Peralta Reyes, F.S, Gremer, L, Schemmert, S, Frieg, B, Willuweit, A, Donner, L, Elvers, M, Nilsson, L.N.G, Syvanen, S, Sehlin, D, Ingelsson, M, Willbold, D, Schroeder, G.F. | 登録日 | 2023-03-30 | 公開日 | 2023-11-29 | 最終更新日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Cryo-EM of A beta fibrils from mouse models find tg-APP ArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease. Nat.Neurosci., 26, 2023
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8OY0
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![BU of 8oy0 by Molmil](/molmil-images/mine/8oy0) | ATP phosphoribosyltransferase (HisZG ATPPRT) from Acinetobacter baumanii | 分子名称: | ATP phosphoribosyltransferase, ATP phosphoribosyltransferase regulatory subunit, GLYCEROL, ... | 著者 | Alphey, M.S, Read, B, da Silva, R.G. | 登録日 | 2023-05-03 | 公開日 | 2023-11-29 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal Structure, Steady-State, and Pre-Steady-State Kinetics of Acinetobacter baumannii ATP Phosphoribosyltransferase. Biochemistry, 63, 2024
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