8PC2

SelDeg51 in complex with FKBP51FK1 domain and pVHL:EloB:EloC

Summary for 8PC2

• Entry DOI: 10.2210/pdb8pc2/pdb
• Descriptor: von Hippel-Lindau disease tumor suppressor, Elongin-C, Elongin-B, ... (6 entities in total)
• Functional Keywords: fkbp51, safit, complex, protac, isomerase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 8
• Total formula weight: 113545.88

Authors

Meyners, C.,Walz, M.,Geiger, T.M.,Hausch, F. (deposition date: 2023-06-09, release date: 2023-11-15, Last modification date: 2024-01-24)

• Primary citation: Geiger, T.M.,Walz, M.,Meyners, C.,Kuehn, A.,Dreizler, J.K.,Sugiarto, W.O.,Maciel, E.V.S.,Zheng, M.,Lermyte, F.,Hausch, F.; Discovery of a Potent Proteolysis Targeting Chimera Enables Targeting the Scaffolding Functions of FK506-Binding Protein 51 (FKBP51).; Angew.Chem.Int.Ed.Engl., 63:e202309706-e202309706, 2024; PubMed: 37942685; DOI: 10.1002/anie.202309706

Experimental method

X-RAY DIFFRACTION (2.8 Å)