8PC2

SelDeg51 in complex with FKBP51FK1 domain and pVHL:EloB:EloC

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	B, A	von Hippel-Lindau disease tumor suppressor	polymer	162	18702.3	2	UniProt (P40337) Pfam (PF01847) Pfam (PF17211) In PDB	Homo sapiens (human)	Protein G7,pVHL
2	C, E	Elongin-C	polymer	97	10974.6	2	UniProt (Q15369) Pfam (PF03931) In PDB	Homo sapiens (human)	EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1
3	D, F	Elongin-B	polymer	104	11748.4	2	UniProt (Q15370) Pfam (PF00240) In PDB	Homo sapiens (human)	EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2
4	G, H	Peptidyl-prolyl cis-trans isomerase FKBP5	polymer	128	14004.0	2	UniProt (Q13451) Pfam (PF00254) In PDB	Homo sapiens (human)	PPIase FKBP5,51 kDa FK506-binding protein,FKBP-51,54 kDa progesterone receptor-associated immunophilin,Androgen-regulated protein 6,FF1 antigen,FK506-binding protein 5,FKBP-5,FKBP54,p54,HSP90-binding immunophilin,Rotamase
5	B, A	[(1~{R})-3-(3,4-dimethoxyphenyl)-1-[4-[[1-[3-[2-[[[(2~{S},4~{R})-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-4-oxidanyl-pyrrolidin-2-yl]carbonylamino]methyl]-5-(4-methyl-1,3-thiazol-5-yl)phenoxy]propyl]-1,2,3-triazol-4-yl]methoxy]phenyl]propyl] (2~{S})-1-[(2~{S})-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)ethanoyl]piperidine-2-carboxylate	non-polymer		1343.6	2	Chemie (XZW)
6		water	water		18.0	14	Chemie (HOH)

Sequence modifications

B, A: 54 - 213 (UniProt: P40337)

PDB	External Database	Details
Gly 52	-	expression tag
Ser 53	-	expression tag

C, E: 17 - 112 (UniProt: Q15369)

PDB	External Database	Details
Met 16	-	initiating methionine

G, H: 16 - 140 (UniProt: Q13451)

PDB	External Database	Details
Gly 13	-	expression tag
Ala 14	-	expression tag
Pro 15	-	expression tag
Thr 19	Ala 19	engineered mutation
Ala 103	Cys 103	engineered mutation
Ile 107	Cys 107	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	110858.7
Non-Polymers*	Number of molecules	2
	Total formula weight	2687.2
All*	Total formula weight	113545.9

*Water molecules are not included.