8PDF

FKBP12 in complex with PROTAC 6a2

Summary for 8PDF

• Entry DOI: 10.2210/pdb8pdf/pdb
• Descriptor: Peptidyl-prolyl cis-trans isomerase FKBP1A, (2~{S},4~{R})-1-[(2~{S})-2-[2-[2-[2-[4-[(1~{S})-1-[(1~{S},5~{S},6~{R})-10-[3,5-bis(chloranyl)phenyl]sulfonyl-5-ethenyl-2-oxidanylidene-3,10-diazabicyclo[4.3.1]decan-3-yl]ethyl]-1,2,3-triazol-1-yl]ethoxy]ethoxy]ethanoylamino]-3,3-dimethyl-butanoyl]-~{N}-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide (3 entities in total)
• Functional Keywords: fkbp12, complex, protac, isomerase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 12875.58

Authors

Meyners, C.,Walz, M.,Geiger, T.M.,Hausch, F. (deposition date: 2023-06-12, release date: 2023-11-15, Last modification date: 2024-01-24)

• Primary citation: Geiger, T.M.,Walz, M.,Meyners, C.,Kuehn, A.,Dreizler, J.K.,Sugiarto, W.O.,Maciel, E.V.S.,Zheng, M.,Lermyte, F.,Hausch, F.; Discovery of a Potent Proteolysis Targeting Chimera Enables Targeting the Scaffolding Functions of FK506-Binding Protein 51 (FKBP51).; Angew.Chem.Int.Ed.Engl., 63:e202309706-e202309706, 2024; PubMed: 37942685; DOI: 10.1002/anie.202309706

Experimental method

X-RAY DIFFRACTION (1.2 Å)