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FKBP12 in complex with PROTAC 6a2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Peptidyl-prolyl cis-trans isomerase FKBP1A | polymer | 107 | 11832.5 | 1 | UniProt (P62942) Pfam (PF00254) In PDB | Homo sapiens (human) | PPIase FKBP1A,12 kDa FK506-binding protein,12 kDa FKBP,FKBP-12,Calstabin-1,FK506-binding protein 1A,FKBP-1A,Immunophilin FKBP12,Rotamase |
| 2 | A | (2~{S},4~{R})-1-[(2~{S})-2-[2-[2-[2-[4-[(1~{S})-1-[(1~{S},5~{S},6~{R})-10-[3,5-bis(chloranyl)phenyl]sulfonyl-5-ethenyl-2-oxidanylidene-3,10-diazabicyclo[4.3.1]decan-3-yl]ethyl]-1,2,3-triazol-1-yl]ethoxy]ethoxy]ethanoylamino]-3,3-dimethyl-butanoyl]-~{N}-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide | non-polymer | 1043.1 | 1 | Chemie (Y5Q) | |||
| 3 | water | water | 18.0 | 152 | Chemie (HOH) |
Sequence modifications
A: 1 - 107 (UniProt: P62942)
| PDB | External Database | Details |
|---|---|---|
| Val 22 | Cys 23 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 11832.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 1043.1 | |
| All* | Total formula weight | 12875.6 |
