4KUM
| Structure of LSD1-CoREST-Tetrahydrofolate complex | 分子名称: | (6S)-5,6,7,8-TETRAHYDROFOLATE, CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... | 著者 | Luka, Z, Pakhomova, S, Loukachevitch, L.V, Calcutt, M.W, Newcomer, M.E, Wagner, C. | 登録日 | 2013-05-22 | 公開日 | 2014-05-07 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | 主引用文献 | Crystal structure of the histone lysine specific demethylase LSD1 complexed with tetrahydrofolate. Protein Sci., 23, 2014
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4KXY
| Human transketolase in complex with ThDP analogue (R)-2-(1,2-dihydroxyethyl)-3-deaza-ThDP | 分子名称: | 1,2-ETHANEDIOL, 2-{4-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-[(1R)-1,2-dihydroxyethyl]-3-methylthiophen-2-yl}ethyl trihydrogen diphosphate, CALCIUM ION, ... | 著者 | Neumann, P, Luedtke, S, Erixon, K.M, Leeper, F, Kluger, R, Ficner, R, Tittmann, K. | 登録日 | 2013-05-28 | 公開日 | 2013-08-21 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.26 Å) | 主引用文献 | Sub-angstrom-resolution crystallography reveals physical distortions that enhance reactivity of a covalent enzymatic intermediate. Nat Chem, 5, 2013
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1VKX
| CRYSTAL STRUCTURE OF THE NFKB P50/P65 HETERODIMER COMPLEXED TO THE IMMUNOGLOBULIN KB DNA | 分子名称: | DNA (5'-D(*AP*GP*GP*AP*AP*AP*GP*TP*CP*CP*CP*C)-3'), DNA (5'-D(*TP*GP*GP*GP*GP*AP*CP*TP*TP*TP*CP*C)-3'), PROTEIN (NF-KAPPA B P50 SUBUNIT), ... | 著者 | Chen, F, Huang, D.B, Ghosh, G. | 登録日 | 1997-09-17 | 公開日 | 1998-12-09 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Crystal structure of p50/p65 heterodimer of transcription factor NF-kappaB bound to DNA. Nature, 391, 1998
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4L4S
| Structural characterisation of the NADH binary complex of human lactate dehydrogenase M isozyme | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, L-lactate dehydrogenase A chain | 著者 | Dempster, S, Harper, S, Moses, J.E, Dreveny, I. | 登録日 | 2013-06-09 | 公開日 | 2014-04-30 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structural characterization of the apo form and NADH binary complex of human lactate dehydrogenase. Acta Crystallogr.,Sect.D, 70, 2014
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4JEF
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1YPV
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1YND
| Structure of human cyclophilin A in complex with the novel immunosuppressant sanglifehrin A at 1.6A resolution | 分子名称: | Peptidyl-prolyl cis-trans isomerase A, SANGLIFEHRIN A | 著者 | Kallen, J, Sedrani, R, Zenke, G, Wagner, J. | 登録日 | 2005-01-24 | 公開日 | 2005-04-05 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structure of human cyclophilin A in complex with the novel immunosuppressant sanglifehrin A at 1.6 A resolution. J.Biol.Chem., 280, 2005
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4J8M
| Aurora A in complex with CD532 | 分子名称: | 1,2-ETHANEDIOL, 1-[4-[[4-[(5-cyclopentyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]amino]phenyl]-3-[3-(trifluoromethyl)phenyl]urea, Aurora kinase A, ... | 著者 | Meyerowitz, J.G, Gustafson, W.C, Shokat, K.M, Weiss, W.A. | 登録日 | 2013-02-14 | 公開日 | 2014-09-10 | 最終更新日 | 2017-11-15 | 実験手法 | X-RAY DIFFRACTION (1.853 Å) | 主引用文献 | Drugging MYCN through an Allosteric Transition in Aurora Kinase A. Cancer Cell, 26, 2014
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4L6S
| PARP complexed with benzo[1,4]oxazin-3-one inhibitor | 分子名称: | (2S)-6-{[4-(4-chlorophenyl)-3,6-dihydropyridin-1(2H)-yl]methyl}-2-methyl-2H-1,4-benzoxazin-3(4H)-one, Poly [ADP-ribose] polymerase 1 | 著者 | Dougan, D.R, Mol, C.D, Lawson, J.D. | 登録日 | 2013-06-12 | 公開日 | 2013-08-07 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Discovery of novel benzo[b][1,4]oxazin-3(4H)-ones as poly(ADP-ribose)polymerase inhibitors Bioorg.Med.Chem.Lett., 23, 2013
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4LDD
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4LNU
| Nucleotide-free kinesin motor domain in complex with tubulin and a DARPin | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Designed ankyrin repeat protein (DARPIN) D1, GLYCEROL, ... | 著者 | Cao, L, Gigant, B, Knossow, M. | 登録日 | 2013-07-12 | 公開日 | 2014-12-03 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | The structure of apo-kinesin bound to tubulin links the nucleotide cycle to movement Nat Commun, 5, 2014
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4KXW
| Human transketolase in covalent complex with donor ketose D-xylulose-5-phosphate, crystal 2 | 分子名称: | 1,2-ETHANEDIOL, D-XYLITOL-5-PHOSPHATE, MAGNESIUM ION, ... | 著者 | Neumann, P, Luedtke, S, Ficner, R, Tittmann, K. | 登録日 | 2013-05-28 | 公開日 | 2013-08-21 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (0.97 Å) | 主引用文献 | Sub-angstrom-resolution crystallography reveals physical distortions that enhance reactivity of a covalent enzymatic intermediate. Nat Chem, 5, 2013
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4KO8
| Structure of p97 N-D1 R155H mutant in complex with ATPgS | 分子名称: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase | 著者 | Xia, D, Tang, W.K. | 登録日 | 2013-05-11 | 公開日 | 2013-11-13 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Altered Intersubunit Communication Is the Molecular Basis for Functional Defects of Pathogenic p97 Mutants. J.Biol.Chem., 288, 2013
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4LDI
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4LDB
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1XNI
| Tandem Tudor Domain of 53BP1 | 分子名称: | Tumor suppressor p53-binding protein 1 | 著者 | Huyen, Y, Zgheib, O, DiTullio Jr, R.A, Gorgoulis, V.G, Zacharatos, P, Petty, T.J, Sheston, E.A, Mellert, H.S, Stavridi, E.S, Halazonetis, T.D. | 登録日 | 2004-10-05 | 公開日 | 2004-11-30 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks Nature, 432, 2004
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4JBP
| Novel Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules | 分子名称: | 1-(4-{2-[(6-{4-[2-(4-hydroxypiperidin-1-yl)ethoxy]phenyl}furo[2,3-d]pyrimidin-4-yl)amino]ethyl}phenyl)-3-phenylurea, Aurora Kinase A | 著者 | Wu, J.S, Leou, J.S, Peng, Y.H, Hsueh, C.C, Hsieh, H.P, Wu, S.Y. | 登録日 | 2013-02-20 | 公開日 | 2013-06-05 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules. Proc.Natl.Acad.Sci.USA, 110, 2013
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4LG9
| Crystal structure of TBL1XR1 WD40 repeats | 分子名称: | F-box-like/WD repeat-containing protein TBL1XR1, UNKNOWN ATOM OR ION | 著者 | Xu, C, Tempel, W, He, H, Wu, X, Seitova, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2013-06-27 | 公開日 | 2014-04-16 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | 主引用文献 | Crystal structure of TBL1XR1 WD40 repeats TO BE PUBLISHED
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1ZAI
| Fructose-1,6-bisphosphate Schiff base intermediate in FBP aldolase from rabbit muscle | 分子名称: | 1,6-FRUCTOSE DIPHOSPHATE (LINEAR FORM), Fructose-bisphosphate aldolase A | 著者 | St-Jean, M, Lafrance-Vanasse, J, Liotard, B, Sygusch, J. | 登録日 | 2005-04-06 | 公開日 | 2005-05-10 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | High Resolution Reaction Intermediates of Rabbit Muscle Fructose-1,6-bisphosphate Aldolase: substrate cleavage and induced fit. J.Biol.Chem., 280, 2005
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4KM8
| Crystal structure of Sufud60 | 分子名称: | Suppressor of fused homolog | 著者 | Zhang, Y, Qi, X, Zhang, Z, Wu, G. | 登録日 | 2013-05-08 | 公開日 | 2013-11-20 | 最終更新日 | 2017-11-15 | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | 主引用文献 | Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci. Nat Commun, 4, 2013
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1Z7G
| Free human HGPRT | 分子名称: | Hypoxanthine-guanine phosphoribosyltransferase | 著者 | Keough, D.T, Brereton, I.M, de Jersey, J, Guddat, L.W. | 登録日 | 2005-03-24 | 公開日 | 2005-08-02 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The Crystal Structure of Free Human Hypoxanthine-guanine Phosphoribosyltransferase Reveals Extensive Conformational Plasticity Throughout the Catalytic Cycle J.Mol.Biol., 351, 2005
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1ZAJ
| Fructose-1,6-bisphosphate aldolase from rabbit muscle in complex with mannitol-1,6-bisphosphate, a competitive inhibitor | 分子名称: | D-MANNITOL-1,6-DIPHOSPHATE, Fructose-bisphosphate aldolase A | 著者 | St-Jean, M, Lafrance-Vanasse, J, Liotard, B, Sygusch, J. | 登録日 | 2005-04-06 | 公開日 | 2005-05-10 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | High Resolution Reaction Intermediates of Rabbit Muscle Fructose-1,6-bisphosphate Aldolase: substrate cleavage and induced fit. J.Biol.Chem., 280, 2005
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4KN6
| Crystal structure of human hypoxanthine-guanine phosphoribosyltransferase in complex with 6-fluoro-3-hydroxy-2-pyrazinecarboxamide (T-705) ribose-5'-monophosphate | 分子名称: | 6-fluoro-3-oxo-4-(5-O-phosphono-beta-D-ribofuranosyl)-3,4-dihydropyrazine-2-carboxamide, Hypoxanthine-guanine phosphoribosyltransferase | 著者 | Naesens, L, Guddat, L, Keough, D, van Kuilenburg, A.B.P, Meijer, J, Vande Voorde, J, Balzarini, J. | 登録日 | 2013-05-08 | 公開日 | 2013-08-14 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.728 Å) | 主引用文献 | Role of human hypoxanthine Guanine phosphoribosyltransferase in activation of the antiviral agent T-705 (favipiravir). Mol.Pharmacol., 84, 2013
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1YD9
| 1.6A Crystal Structure of the Non-Histone Domain of the Histone Variant MacroH2A1.1. | 分子名称: | Core histone macro-H2A.1, GOLD ION | 著者 | Chakravarthy, S, Swamy, G.Y.S.K, Caron, C, Perche, P.Y, Pehrson, J.R, Khochbin, S, Luger, K. | 登録日 | 2004-12-23 | 公開日 | 2005-09-27 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structural characterization of the histone variant macroH2A Mol.Cell.Biol., 25, 2005
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4LBD
| LIGAND-BINDING DOMAIN OF THE HUMAN RETINOIC ACID RECEPTOR GAMMA BOUND TO THE SYNTHETIC AGONIST BMS961 | 分子名称: | 3-FLUORO-4-[2-HYDROXY-2-(5,5,8,8-TETRAMETHYL-5,6,7,8,-TETRAHYDRO-NAPHTALEN-2-YL)-ACETYLAMINO]-BENZOIC ACID, RETINOIC ACID RECEPTOR GAMMA | 著者 | Klaholz, B.P, Renaud, J.-P, Mitschler, A, Moras, D, Structural Proteomics in Europe (SPINE) | 登録日 | 1998-02-04 | 公開日 | 1999-03-02 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Conformational adaptation of agonists to the human nuclear receptor RAR gamma. Nat.Struct.Biol., 5, 1998
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