4J8M

Aurora A in complex with CD532

Summary for 4J8M

• Entry DOI: 10.2210/pdb4j8m/pdb
• Related: 4J8N
• Descriptor: Aurora kinase A, 1-[4-[[4-[(5-cyclopentyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]amino]phenyl]-3-[3-(trifluoromethyl)phenyl]urea, MAGNESIUM ION, ... (7 entities in total)
• Functional Keywords: aurora a, type ii, kinase inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : O14965
• Total number of polymer chains: 1
• Total formula weight: 33339.24

Authors

Meyerowitz, J.G.,Gustafson, W.C.,Shokat, K.M.,Weiss, W.A. (deposition date: 2013-02-14, release date: 2014-09-10, Last modification date: 2017-11-15)

• Primary citation: Gustafson, W.C.,Meyerowitz, J.G.,Nekritz, E.A.,Chen, J.,Benes, C.,Charron, E.,Simonds, E.F.,Seeger, R.,Matthay, K.K.,Hertz, N.T.,Eilers, M.,Shokat, K.M.,Weiss, W.A.; Drugging MYCN through an Allosteric Transition in Aurora Kinase A.; Cancer Cell, 26:414-427, 2014; PubMed: 25175806; DOI: 10.1016/j.ccr.2014.07.015

Experimental method

X-RAY DIFFRACTION (1.853 Å)