4KN6
Crystal structure of human hypoxanthine-guanine phosphoribosyltransferase in complex with 6-fluoro-3-hydroxy-2-pyrazinecarboxamide (T-705) ribose-5'-monophosphate
Summary for 4KN6
Entry DOI | 10.2210/pdb4kn6/pdb |
Descriptor | Hypoxanthine-guanine phosphoribosyltransferase, 6-fluoro-3-oxo-4-(5-O-phosphono-beta-D-ribofuranosyl)-3,4-dihydropyrazine-2-carboxamide (3 entities in total) |
Functional Keywords | favipiravir, 6-oxopurine phosphoribosyltransferase, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P00492 |
Total number of polymer chains | 1 |
Total formula weight | 24779.34 |
Authors | Naesens, L.,Guddat, L.,Keough, D.,van Kuilenburg, A.B.P.,Meijer, J.,Vande Voorde, J.,Balzarini, J. (deposition date: 2013-05-08, release date: 2013-08-14, Last modification date: 2024-02-28) |
Primary citation | Naesens, L.,Guddat, L.W.,Keough, D.T.,van Kuilenburg, A.B.,Meijer, J.,Vande Voorde, J.,Balzarini, J. Role of human hypoxanthine Guanine phosphoribosyltransferase in activation of the antiviral agent T-705 (favipiravir). Mol.Pharmacol., 84:615-629, 2013 Cited by PubMed: 23907213DOI: 10.1124/mol.113.087247 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.728 Å) |
Structure validation
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