PDB: 5495 件ウェブページステータス検索Chemie searchBIRD

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5TLW	Fructose-1,6-bisphosphate aldolase from rabbit muscle in complex with the inhibitor 1-phosphate-benzene 4-bisphosphonate 分子名称: Fructose-bisphosphate aldolase A, GLYCEROL, {[4-(phosphonooxy)phenyl]methylene}bis(phosphonic acid) 著者 Heron, P.W, Sygusch, J. 登録日 2016-10-12 公開日 2017-10-25 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.29 Å) 主引用文献 Bisphosphonate Inhibitors of Mammalian Glycolytic Aldolase. J.Med.Chem., 61, 2018
5TEG	Crystal structure of hSETD8 in complex with histone H4K20 norleucine mutant peptide and S-Adenosylmethionine 分子名称: Histone H4 mutant peptide with H4K20norleucine, N-lysine methyltransferase KMT5A, S-ADENOSYLMETHIONINE 著者 Judge, R.A, Petros, A.M. 登録日 2016-09-21 公開日 2016-12-07 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Turning a Substrate Peptide into a Potent Inhibitor for the Histone Methyltransferase SETD8. ACS Med Chem Lett, 7, 2016
4Z3A	Acetate-free structure of the enzyme-product complex resulting from TDG action on a GU mismatch 分子名称: DNA (28-MER), G/T mismatch-specific thymine DNA glycosylase 著者 Pozharski, E, Malik, S.S, Drohat, A.C. 登録日 2015-03-31 公開日 2015-09-16 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 Thymine DNA glycosylase exhibits negligible affinity for nucleobases that it removes from DNA. Nucleic Acids Res., 43, 2015
8EJM	Crystal structure of human DEAH-box helicase DHX15 in complex with SUGP1 G-patch 分子名称: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent RNA helicase DHX15, CHLORIDE ION, ... 著者 Huang, J, Tong, L. 登録日 2022-09-17 公開日 2022-12-14 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 DHX15 is involved in SUGP1-mediated RNA missplicing by mutant SF3B1 in cancer. Proc.Natl.Acad.Sci.USA, 119, 2022
8EHG	Rabbit muscle aldolase determined using single-particle cryo-EM with Apollo camera. 分子名称: Fructose-bisphosphate aldolase A 著者 Peng, R, Fu, X, Mendez, J.H, Randolph, P.H, Bammes, B, Stagg, S.M. 登録日 2022-09-14 公開日 2022-12-21 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.24 Å) 主引用文献 Characterizing the resolution and throughput of the Apollo direct electron detector. J Struct Biol X, 7, 2023
5TI5	CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH INHIBITOR 8841880 分子名称: 1,2-ETHANEDIOL, 3-bromo-N-[3-(2-oxo-2,3-dihydro-1H-pyrrol-1-yl)phenyl]benzene-1-sulfonamide, Bromodomain-containing protein 4 著者 Zhu, J.-Y, Ember, S.W.J, Schonbrunn, E. 登録日 2016-10-01 公開日 2017-08-09 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Identification of a Novel Class of BRD4 Inhibitors by Computational Screening and Binding Simulations. ACS Omega, 2, 2017
4Z7Z	Structure of the enzyme-product complex resulting from TDG action on a GT mismatch in the presence of excess base 分子名称: 1,2-ETHANEDIOL, ACETIC ACID, DNA (28-MER), ... 著者 Pozharski, E, Malik, S.S, Drohat, A.C. 登録日 2015-04-08 公開日 2015-09-16 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Thymine DNA glycosylase exhibits negligible affinity for nucleobases that it removes from DNA. Nucleic Acids Res., 43, 2015
4Z96	Crystal structure of DNMT1 in complex with USP7 分子名称: DNA (cytosine-5)-methyltransferase 1, Ubiquitin carboxyl-terminal hydrolase 7 著者 Zhang, Z.M, Song, J. 登録日 2015-04-09 公開日 2016-10-12 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Crystal structure of DNMT1 in complex with USP7 To Be Published
5TIJ	Structure of Human Enolase 2 with ((3S,5S)-1,5-dihydroxy-3-methyl-2-oxopyrrolidin-3-yl)phosphonate (purified enantiomer) 分子名称: ((3S,5S)-1,5-dihydroxy-3-methyl-2-oxopyrrolidin-3-yl)phosphonic acid, Gamma-enolase, MAGNESIUM ION 著者 Leonard, P.G, Muller, F.L. 登録日 2016-10-03 公開日 2017-10-18 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.634 Å) 主引用文献 Eradication of ENO1-deleted Glioblastoma through Collateral Lethality Biorxiv, 2019
5TI4	CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH INHIBITOR 8841871 分子名称: 1,2-ETHANEDIOL, 3-chloro-4-fluoro-N-[3-(2-oxopyrrolidin-1-yl)phenyl]benzene-1-sulfonamide, Bromodomain-containing protein 4 著者 Zhu, J.-Y, Ember, S.W.J, SCHONBRUNN, E. 登録日 2016-09-30 公開日 2017-08-09 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.62 Å) 主引用文献 Identification of a Novel Class of BRD4 Inhibitors by Computational Screening and Binding Simulations. ACS Omega, 2, 2017
4ZA0	Structure of Human Enolase 2 in complex with Phosphonoacetohydroxamate 分子名称: Gamma-enolase, MAGNESIUM ION, PHOSPHONOACETOHYDROXAMIC ACID 著者 Leonard, P.G, Maxwell, D, Czako, B, Muller, F.L. 登録日 2015-04-13 公開日 2016-04-13 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.31 Å) 主引用文献 SF2312 is a natural phosphonate inhibitor of enolase. Nat.Chem.Biol., 12, 2016
5VTB	Crystal structure of RBBP4 bound to BCL11a peptide 分子名称: B-cell lymphoma/leukemia 11A, GLYCEROL, Histone-binding protein RBBP4 著者 Meagher, J.L, Stuckey, J.A. 登録日 2017-05-16 公開日 2017-12-27 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Probing the interaction between the histone methyltransferase/deacetylase subunit RBBP4/7 and the transcription factor BCL11A in epigenetic complexes. J. Biol. Chem., 293, 2018
4Z49	Homo Sapiens Fatty Acid Synthetase, Thioesterase Domain at 1.7 Angstroms Resolution 分子名称: Fatty acid synthase, POTASSIUM ION 著者 Spraggon, G. 登録日 2015-04-01 公開日 2016-03-16 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Estimation of Hydrogen-Exchange Protection Factors from MD Simulation Based on Amide Hydrogen Bonding Analysis. J.Chem.Inf.Model., 55, 2015
5UWR	Crystal Structure of CDC7 NES Peptide (extended) in complex with CRM1-Ran-RanBP1 分子名称: CHLORIDE ION, Cell division cycle 7-related protein kinase, Exportin-1, ... 著者 Fung, H.Y.J, Chook, Y.M. 登録日 2017-02-21 公開日 2017-03-22 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.24 Å) 主引用文献 Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals. Elife, 6, 2017
5UPD	Methyltransferase domain of human Wolf-Hirschhorn Syndrome Candidate 1-Like protein 1 (WHSC1L1) 分子名称: Histone-lysine N-methyltransferase NSD3, S-ADENOSYLMETHIONINE, UNKNOWN ATOM OR ION, ... 著者 Tempel, W, Yu, W, Dong, A, Cerovina, T, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Wu, H, Structural Genomics Consortium (SGC) 登録日 2017-02-02 公開日 2017-02-15 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Methyltransferase domain of human Wolf-Hirschhorn Syndrome Candidate 1-Like protein 1 (WHSC1L1) To Be Published
4Z7B	Structure of the enzyme-product complex resulting from TDG action on a GfC mismatch 分子名称: 1,2-ETHANEDIOL, ACETIC ACID, DNA (28-MER), ... 著者 Pozharski, E, Malik, S.S, Drohat, A.C. 登録日 2015-04-07 公開日 2015-09-16 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Thymine DNA glycosylase exhibits negligible affinity for nucleobases that it removes from DNA. Nucleic Acids Res., 43, 2015
5VOM	Benzopiperazine BET bromodomain inhibitor in complex with BD1 of Brd4 分子名称: 3-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquinoxalin-6-yl]-N-methylbenzamide, Bromodomain-containing protein 4 著者 Toms, A.V, Herbertz, T. 登録日 2017-05-03 公開日 2017-08-02 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 Design and Optimization of Benzopiperazines as Potent Inhibitors of BET Bromodomains. ACS Med Chem Lett, 8, 2017
5T2W	Structure of thymine DNA glycosylase bound to substrate analog 2'-F-5-formyl-dC 分子名称: DNA (27-MER), DNA (28-MER), G/T mismatch-specific thymine DNA glycosylase 著者 Pidugu, L.S, Pozharski, E, Drohat, A.C. 登録日 2016-08-24 公開日 2016-11-09 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural Basis for Excision of 5-Formylcytosine by Thymine DNA Glycosylase. Biochemistry, 55, 2016
5VY5	Rabbit muscle aldolase using 200keV 分子名称: Fructose-bisphosphate aldolase A 著者 Herzik Jr, M.A, Wu, M, Lander, G.C. 登録日 2017-05-24 公開日 2017-06-14 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (2.6 Å) 主引用文献 Achieving better-than-3- angstrom resolution by single-particle cryo-EM at 200 keV. Nat. Methods, 14, 2017
5VZS	BRD4-BD1 in complex with Cpd19 (3-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-N-methyl-1-(tetrahydro-2H-pyran-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide) 分子名称: 1,2-ETHANEDIOL, 3-[7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl]-N-methyl-1-(oxan-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide, Bromodomain-containing protein 4 著者 Murray, J.M. 登録日 2017-05-29 公開日 2018-05-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.707 Å) 主引用文献 GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of CBP/P300 To be published
3I7O	Crystal Structure of DDB1 in Complex with the H-Box Motif of IQWD1 分子名称: DNA damage-binding protein 1, IQ motif and WD repeat-containing protein 1 著者 Li, T, Robert, E.I, Breugel, P.C.V, Strubin, M, Zheng, N. 登録日 2009-07-08 公開日 2009-12-08 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery. Nat.Struct.Mol.Biol., 17, 2010
3IHI	Crystal structure of mouse thymidylate synthase 分子名称: SULFATE ION, Thymidylate synthase 著者 Dowiercial, A, Jarmula, A, Rypniewski, W.R, Sokolowska, M, Fraczyk, T, Ciesla, J, Rode, W. 登録日 2009-07-30 公開日 2010-02-02 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Mouse thymidylate synthase does not show the inactive conformation, observed for the human enzyme Struct Chem, 2016
3I7N	Crystal Structure of DDB1 in Complex with the H-Box Motif of WDTC1 分子名称: DNA damage-binding protein 1, WD and tetratricopeptide repeats protein 1 著者 Li, T, Robert, E.I, Breugel, P.C.V, Strubin, M, Zheng, N. 登録日 2009-07-08 公開日 2009-12-08 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery. Nat.Struct.Mol.Biol., 17, 2010
1ADO	FRUCTOSE 1,6-BISPHOSPHATE ALDOLASE FROM RABBIT MUSCLE 分子名称: 1,3-DIHYDROXYACETONEPHOSPHATE, ALDOLASE, SULFATE ION 著者 Blom, N.S, Sygusch, J. 登録日 1996-12-02 公開日 1997-12-24 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Product binding and role of the C-terminal region in class I D-fructose 1,6-bisphosphate aldolase. Nat.Struct.Biol., 4, 1997
3QWZ	Crystal structure of FAF1 UBX-p97N-domain complex 分子名称: FAS-associated factor 1, Transitional endoplasmic reticulum ATPase 著者 Park, J.K, Jeon, H, Lee, J.J, Kim, K.H, Lee, K.J, Kim, E.E. 登録日 2011-02-28 公開日 2012-05-09 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Dissection of the interaction between FAF1 UBX and p97 To be Published

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