5VOM
Benzopiperazine BET bromodomain inhibitor in complex with BD1 of Brd4
Summary for 5VOM
| Entry DOI | 10.2210/pdb5vom/pdb |
| Descriptor | Bromodomain-containing protein 4, 3-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquinoxalin-6-yl]-N-methylbenzamide (3 entities in total) |
| Functional Keywords | bromodomain brd4 bet benzopiperazine, transcription-inhibitor complex, transcription/inhibitor |
| Biological source | Homo sapiens (Human) |
| Cellular location | Nucleus: O60885 |
| Total number of polymer chains | 2 |
| Total formula weight | 36084.99 |
| Authors | Toms, A.V.,Herbertz, T. (deposition date: 2017-05-03, release date: 2017-08-02, Last modification date: 2024-03-13) |
| Primary citation | Millan, D.S.,Kayser-Bricker, K.J.,Martin, M.W.,Talbot, A.C.,Schiller, S.E.R.,Herbertz, T.,Williams, G.L.,Luke, G.P.,Hubbs, S.,Alvarez Morales, M.A.,Cardillo, D.,Troccolo, P.,Mendes, R.L.,McKinnon, C. Design and Optimization of Benzopiperazines as Potent Inhibitors of BET Bromodomains. ACS Med Chem Lett, 8:847-852, 2017 Cited by PubMed: 28835800DOI: 10.1021/acsmedchemlett.7b00191 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.67 Å) |
Structure validation
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