5VZS

BRD4-BD1 in complex with Cpd19 (3-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-N-methyl-1-(tetrahydro-2H-pyran-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide)

Summary for 5VZS

• Entry DOI: 10.2210/pdb5vzs/pdb
• Descriptor: Bromodomain-containing protein 4, 1,2-ETHANEDIOL, 3-[7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl]-N-methyl-1-(oxan-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide, ... (4 entities in total)
• Functional Keywords: brd4, bromodomain, small molecule inhibitor, transcription regulator-inhibitor complex, transcription regulator/inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus: O60885
• Total number of polymer chains: 2
• Total formula weight: 38651.89

Authors

Murray, J.M. (deposition date: 2017-05-29, release date: 2018-05-30, Last modification date: 2023-10-04)

• Primary citation: Murray, J.M.; GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of CBP/P300; To be published,

Experimental method

X-RAY DIFFRACTION (1.707 Å)