5VZS
BRD4-BD1 in complex with Cpd19 (3-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-N-methyl-1-(tetrahydro-2H-pyran-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide)
Summary for 5VZS
Entry DOI | 10.2210/pdb5vzs/pdb |
Descriptor | Bromodomain-containing protein 4, 1,2-ETHANEDIOL, 3-[7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl]-N-methyl-1-(oxan-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide, ... (4 entities in total) |
Functional Keywords | brd4, bromodomain, small molecule inhibitor, transcription regulator-inhibitor complex, transcription regulator/inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus: O60885 |
Total number of polymer chains | 2 |
Total formula weight | 38651.89 |
Authors | Murray, J.M. (deposition date: 2017-05-29, release date: 2018-05-30, Last modification date: 2023-10-04) |
Primary citation | Murray, J.M. GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of CBP/P300 To be published, |
Experimental method | X-RAY DIFFRACTION (1.707 Å) |
Structure validation
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