5VZS
BRD4-BD1 in complex with Cpd19 (3-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-N-methyl-1-(tetrahydro-2H-pyran-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide)
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 201 |
| Chain | Residue |
| A | ILE100 |
| A | ILE101 |
| A | LYS102 |
| A | THR103 |
| A | ASN135 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue 9U4 A 202 |
| Chain | Residue |
| A | TYR139 |
| A | ASN140 |
| A | HOH304 |
| A | HOH326 |
| B | GLN78 |
| B | 9U4203 |
| A | TRP81 |
| A | PHE83 |
| A | LEU92 |
| A | LEU94 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 201 |
| Chain | Residue |
| B | ILE100 |
| B | ILE101 |
| B | LYS102 |
| B | THR103 |
| B | ASN135 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 202 |
| Chain | Residue |
| B | TRP75 |
| B | LYS76 |
| B | HIS77 |
| B | GLN84 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | binding site for residue 9U4 B 203 |
| Chain | Residue |
| A | 9U4202 |
| B | GLN78 |
| B | TRP81 |
| B | PRO82 |
| B | PHE83 |
| B | ASN140 |
| B | MET149 |
| B | HOH307 |
| B | HOH330 |
Functional Information from PROSITE/UniProt
| site_id | PS00633 |
| Number of Residues | 60 |
| Details | BROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY |
| Chain | Residue | Details |
| A | ALA80-TYR139 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | ASN140 | |
| B | ASN140 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| A | LYS99 | |
| B | LYS99 | |
