5TLW

Fructose-1,6-bisphosphate aldolase from rabbit muscle in complex with the inhibitor 1-phosphate-benzene 4-bisphosphonate

Summary for 5TLW

Entry DOI	10.2210/pdb5tlw/pdb
Related	5TLE 5TLH 5TLZ
Descriptor	Fructose-bisphosphate aldolase A, {[4-(phosphonooxy)phenyl]methylene}bis(phosphonic acid), GLYCEROL, ... (4 entities in total)
Functional Keywords	inhibitor, bisphosphonate, complex, aldolase, lyase, lyase-inhibitor complex, lyase/inhibitor
Biological source	Oryctolagus cuniculus (Rabbit)
Total number of polymer chains	4
Total formula weight	158631.19
Authors	Heron, P.W.,Sygusch, J. (deposition date: 2016-10-12, release date: 2017-10-25, Last modification date: 2023-10-18)
Primary citation	Heron, P.W.,Abellan-Flos, M.,Salmon, L.,Sygusch, J. Bisphosphonate Inhibitors of Mammalian Glycolytic Aldolase. J.Med.Chem., 61:10558-10572, 2018 Cited by PubMed: 30418024 DOI: 10.1021/acs.jmedchem.8b01000 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.29 Å)

Structure validation