PDB: 2561 件ウェブページステータス検索Chemie searchBIRD

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7QO1	complex of DNA ligase I and FEN1 on PCNA and DNA 分子名称: ADENOSINE MONOPHOSPHATE, DNA ligase 1, Flap endonuclease 1, ... 著者 Blair, K, Tehseen, M, Raducanu, V.S, Shahid, T, Lancey, C, Cruehet, R, Hamdan, S, De Biasio, A. 登録日 2021-12-23 公開日 2023-01-11 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (4.4 Å) 主引用文献 Mechanism of human Lig1 regulation by PCNA in Okazaki fragment sealing. Nat Commun, 13, 2022
6HHF	Crystal Structure of AKT1 in Complex with Covalent-Allosteric AKT Inhibitor Borussertib 分子名称: Borussertib, RAC-alpha serine/threonine-protein kinase 著者 Landel, I, Weisner, J, Mueller, M.P, Scheinpflug, R, Rauh, D. 登録日 2018-08-28 公開日 2019-03-20 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Preclinical Efficacy of Covalent-Allosteric AKT Inhibitor Borussertib in Combination with Trametinib inKRAS-Mutant Pancreatic and Colorectal Cancer. Cancer Res., 79, 2019
6HHI	Crystal Structure of AKT1 in Complex with Covalent-Allosteric AKT Inhibitor 30b 分子名称: RAC-alpha serine/threonine-protein kinase, ~{N}-[1-[[4-(5-oxidanylidene-3-phenyl-6~{H}-1,6-naphthyridin-2-yl)phenyl]methyl]piperidin-4-yl]-3-(propanoylamino)benzamide 著者 Landel, I, Weisner, J, Mueller, M.P, Scheinpflug, R, Rauh, D. 登録日 2018-08-28 公開日 2019-02-20 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural and chemical insights into the covalent-allosteric inhibition of the protein kinase Akt. Chem Sci, 10, 2019
6OFC	Crystal structure of M. tuberculosis glutamine-dependent NAD+ synthetase complexed with Sulfonamide derivative 1, pyrophosphate, and glutamine 分子名称: 5'-O-[(pyridine-3-carbonyl)sulfamoyl]adenosine, CHLORIDE ION, GLUTAMINE, ... 著者 Chuenchor, W, Doukov, T.I, Gerratana, B. 登録日 2019-03-28 公開日 2020-01-08 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (3.14 Å) 主引用文献 Different ways to transport ammonia in human and Mycobacterium tuberculosis NAD+synthetases. Nat Commun, 11, 2020
6HHG	Crystal Structure of AKT1 in Complex with Covalent-Allosteric AKT Inhibitor 27 分子名称: RAC-alpha serine/threonine-protein kinase, ~{N}-[2-chloranyl-5-[[1-[[4-(5-oxidanylidene-3-phenyl-6~{H}-1,6-naphthyridin-2-yl)phenyl]methyl]piperidin-4-yl]carbamoylamino]phenyl]propanamide 著者 Landel, I, Weisner, J, Mueller, M.P, Scheinpflug, R, Rauh, D. 登録日 2018-08-28 公開日 2019-02-20 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural and chemical insights into the covalent-allosteric inhibition of the protein kinase Akt. Chem Sci, 10, 2019
6HHJ	Crystal Structure of AKT1 in Complex with Covalent-Allosteric AKT Inhibitor 24b 分子名称: RAC-alpha serine/threonine-protein kinase, ~{N}-[1-methyl-2-oxidanylidene-3-[1-[[4-(5-oxidanylidene-3-phenyl-6~{H}-1,6-naphthyridin-2-yl)phenyl]methyl]piperidin-4-yl]benzimidazol-5-yl]propanamide 著者 Landel, I, Weisner, J, Mueller, M.P, Scheinpflug, R, Rauh, D. 登録日 2018-08-28 公開日 2019-02-20 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural and chemical insights into the covalent-allosteric inhibition of the protein kinase Akt. Chem Sci, 10, 2019
6HHH	Crystal Structure of AKT1 in Complex with Covalent-Allosteric AKT Inhibitor 31 分子名称: RAC-alpha serine/threonine-protein kinase, ~{N}-[4-[4-[[4-(5-oxidanylidene-3-phenyl-6~{H}-1,6-naphthyridin-2-yl)phenyl]methyl]piperazin-1-yl]phenyl]propanamide 著者 Landel, I, Weisner, J, Mueller, M.P, Scheinpflug, R, Rauh, D. 登録日 2018-08-28 公開日 2019-02-20 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural and chemical insights into the covalent-allosteric inhibition of the protein kinase Akt. Chem Sci, 10, 2019
2VWB	Structure of the archaeal Kae1-Bud32 fusion protein MJ1130: a model for the eukaryotic EKC-KEOPS subcomplex involved in transcription and telomere homeostasis. 分子名称: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, PUTATIVE O-SIALOGLYCOPROTEIN ENDOPEPTIDASE 著者 Hecker, A, Lopreiato, R, Graille, M, Collinet, B, Forterre, P, Domenico, L, van Tilbeurgh, H. 登録日 2008-06-20 公開日 2008-08-19 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (3.05 Å) 主引用文献 Structure of the Archaeal Kae1/Bud32 Fusion Protein Mj1130: A Model for the Eukaryotic Ekc/Keops Subcomplex Embo J., 27, 2008
8HZ4	The tetrameric structure of biotin carboxylase from Chloroflexus aurantiacus in complex with bicarbonate 分子名称: Biotin carboxylase 著者 Shen, J, Wu, W, Xu, X. 登録日 2023-01-08 公開日 2024-01-10 最終更新日 2024-07-24 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Chloroflexus aurantiacus acetyl-CoA carboxylase evolves fused biotin carboxylase and biotin carboxyl carrier protein to complete carboxylation activity. Mbio, 15, 2024
6VR0	Agrobacterium Tumefaciens ADP-glucose pyrophosphorylase W106A 分子名称: GLYCEROL, Glucose-1-phosphate adenylyltransferase, SULFATE ION 著者 Mascarenhas, R.N, Liu, D, Ballicora, M, Iglesias, A, Asencion, M, Figueroa, C. 登録日 2020-02-06 公開日 2021-02-17 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Agrobacterium Tumefaciens ADP-glucose pyrophosphorylase W106A To Be Published
6HQV	Pentafunctional AROM Complex from Chaetomium thermophilum 分子名称: (3R,4S,5R)-3,4,5-TRIHYDROXYCYCLOHEX-1-ENE-1-CARBOXYLIC ACID, (4S,5R)-4,5-dihydroxy-3-oxocyclohex-1-ene-1-carboxylic acid, GLUTAMIC ACID, ... 著者 Arora Verasto, H, Hartmann, M.D. 登録日 2018-09-25 公開日 2020-05-06 最終更新日 2020-08-26 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Architecture and functional dynamics of the pentafunctional AROM complex. Nat.Chem.Biol., 16, 2020
7RPW	Archaeal DNA ligase and heterotrimeric PCNA in complex with adenylated DNA 分子名称: ADENOSINE MONOPHOSPHATE, DNA ligase, DNA polymerase sliding clamp 1, ... 著者 Sverzhinsky, A, Pascal, J.M. 登録日 2021-08-04 公開日 2021-11-17 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (4.38 Å) 主引用文献 Cryo-EM structures and biochemical insights into heterotrimeric PCNA regulation of DNA ligase. Structure, 30, 2022
7RPO	Archaeal DNA ligase and heterotrimeric PCNA in complex with non-ligatable DNA 分子名称: ADENOSINE MONOPHOSPHATE, DNA ligase, DNA polymerase sliding clamp 1, ... 著者 Sverzhinsky, A, Pascal, J.M. 登録日 2021-08-03 公開日 2021-11-17 最終更新日 2022-03-16 実験手法 ELECTRON MICROSCOPY (4.16 Å) 主引用文献 Cryo-EM structures and biochemical insights into heterotrimeric PCNA regulation of DNA ligase. Structure, 30, 2022
7RPX	Archaeal DNA ligase and heterotrimeric PCNA in complex with end-joined DNA 分子名称: DNA ligase, DNA polymerase sliding clamp 1, DNA polymerase sliding clamp 2, ... 著者 Sverzhinsky, A, Pascal, J.M. 登録日 2021-08-04 公開日 2021-11-17 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Cryo-EM structures and biochemical insights into heterotrimeric PCNA regulation of DNA ligase. Structure, 30, 2022
7KR3	Human DNA Ligase 1(E346A/E592A) Bound to a bulged DNA substrate 分子名称: ACETATE ION, ADENOSINE MONOPHOSPHATE, DNA (5'-D(*AP*AP*TP*GP*TP*CP*TP*GP*CP*CP*CP*C)-3'), ... 著者 Tumbale, P.P, Williams, R.S. 登録日 2020-11-18 公開日 2021-02-03 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.778 Å) 主引用文献 High-fidelity DNA ligation enforces accurate Okazaki fragment maturation during DNA replication. Nat Commun, 12, 2021
7L34	Human DNA Ligase 1 - R641L nicked DNA complex 分子名称: ADENOSINE MONOPHOSPHATE, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*TP*C)-3'), DNA (5'-D(*GP*TP*CP*CP*GP*AP*CP*GP*AP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ... 著者 Tumbale, P.P, Williams, R.S, Schellenberg, M.S. 登録日 2020-12-17 公開日 2021-01-13 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.901 Å) 主引用文献 LIG1 syndrome mutations remodel a cooperative network of ligand binding interactions to compromise ligation efficiency. Nucleic Acids Res., 49, 2021
7KR4	Human DNA Ligase 1(E346A/E592A) Bound to a nicked DNA substrate control duplex 分子名称: ACETATE ION, ADENOSINE MONOPHOSPHATE, DNA (5'-D(*AP*AP*TP*GP*TP*CP*TP*GP*CP*CP*C)-3'), ... 著者 Tumbale, P.P, Williams, R.S. 登録日 2020-11-18 公開日 2021-02-03 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 High-fidelity DNA ligation enforces accurate Okazaki fragment maturation during DNA replication. Nat Commun, 12, 2021
7L35	Human DNA Ligase 1 - R771W nicked DNA complex 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE MONOPHOSPHATE, DI(HYDROXYETHYL)ETHER, ... 著者 Tumbale, P.P, Williams, R.S, Schellenberg, M.S. 登録日 2020-12-17 公開日 2021-01-13 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 LIG1 syndrome mutations remodel a cooperative network of ligand binding interactions to compromise ligation efficiency. Nucleic Acids Res., 49, 2021
2P02	Crystal structure of the alpha subunit of human S-adenosylmethionine synthetase 2 分子名称: CHLORIDE ION, S-ADENOSYLMETHIONINE, S-adenosylmethionine synthetase isoform type-2 著者 Papagrigoriou, E, Shafqat, N, Rojkova, A, Niessen, F.H, Kavanagh, K.L, von Delft, F, Gorrec, F, Ugochukwu, E, Arrowsmith, C.H, Edwards, A, Weigelt, J, Sundstrom, M, Oppermann, U, Structural Genomics Consortium (SGC) 登録日 2007-02-28 公開日 2007-03-13 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.21 Å) 主引用文献 Crystal structure of the alpha subunit of human S-adenosylmethionine synthetase 2 To be Published
2OBV	Crystal structure of the human S-adenosylmethionine synthetase 1 in complex with the product 分子名称: S-ADENOSYLMETHIONINE, S-adenosylmethionine synthetase isoform type-1, SODIUM ION, ... 著者 Pilka, E.S, Shafqat, N, Kavanagh, K.L, Cooper, C, Hozjan, V, Turnbull, A, von Delft, F, Arrowsmith, C.H, Edwards, A, Weigelt, J, Sundstrom, M, Oppermann, U, Structural Genomics Consortium (SGC) 登録日 2006-12-20 公開日 2007-01-02 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Crystal structure of the human S-adenosylmethionine synthetase 1 in complex with the product. To be Published
6P0B	Human DNA Ligase 1 (E346A/E592A) Bound to an Adenylated, dideoxy Terminated DNA nick with 200 mM Mg2+ 分子名称: ADENOSINE MONOPHOSPHATE, DI(HYDROXYETHYL)ETHER, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*TP*C)-3'), ... 著者 Schellenberg, M.J, Williams, R.S, Tumbale, P.S, Riccio, A.A. 登録日 2019-05-16 公開日 2019-12-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.203 Å) 主引用文献 Two-tiered enforcement of high-fidelity DNA ligation. Nat Commun, 10, 2019
7NH4	Co-Crystal Structure of Akt1 in Complex with Covalent-Allosteric Akt Inhibitor 3 分子名称: ACETATE ION, RAC-alpha serine/threonine-protein kinase, ~{N}-[3-[1-[[4-[5-(hydroxymethyl)-3-phenyl-pyridin-2-yl]phenyl]methyl]piperidin-4-yl]-2-oxidanylidene-1~{H}-benzimidazol-5-yl]propanamide 著者 Landel, I, Mueller, M.P, Rauh, D. 登録日 2021-02-10 公開日 2021-09-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Cellular model system to dissect the isoform-selectivity of Akt inhibitors. Nat Commun, 12, 2021
7NH5	Co-Crystal Structure of Akt1 in Complex with Covalent-Allosteric Akt Inhibitor 6 分子名称: ACETATE ION, RAC-alpha serine/threonine-protein kinase, ~{N}-methyl-6-[4-[[4-[2-oxidanylidene-6-(propanoylamino)-3~{H}-benzimidazol-1-yl]piperidin-1-yl]methyl]phenyl]-5-phenyl-pyridine-3-carboxamide 著者 Landel, I, Mueller, M.P, Rauh, D. 登録日 2021-02-10 公開日 2021-09-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Cellular model system to dissect the isoform-selectivity of Akt inhibitors. Nat Commun, 12, 2021
6P0A	Human DNA Ligase 1 Bound to an Adenylated, dideoxy Terminated DNA nick with 2 mM Mg2+ 分子名称: ADENOSINE MONOPHOSPHATE, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*TP*C)-3'), DNA (5'-D(*GP*TP*CP*CP*GP*AP*CP*GP*AP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ... 著者 Schellenberg, M.J, Williams, R.S, Tumbale, P.S, Riccio, A.A. 登録日 2019-05-16 公開日 2019-12-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Two-tiered enforcement of high-fidelity DNA ligation. Nat Commun, 10, 2019
6P0D	Human DNA Ligase 1 (E346A/E592A) Bound to an Adenylated, hydroxyl terminated DNA nick 分子名称: ADENOSINE MONOPHOSPHATE, DI(HYDROXYETHYL)ETHER, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*TP*C)-3'), ... 著者 Schellenberg, M.J, Williams, R.S, Tumbale, P.S, Riccio, A.A. 登録日 2019-05-16 公開日 2019-12-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Two-tiered enforcement of high-fidelity DNA ligation. Nat Commun, 10, 2019

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