6HHH
Crystal Structure of AKT1 in Complex with Covalent-Allosteric AKT Inhibitor 31
Summary for 6HHH
Entry DOI | 10.2210/pdb6hhh/pdb |
Descriptor | RAC-alpha serine/threonine-protein kinase, ~{N}-[4-[4-[[4-(5-oxidanylidene-3-phenyl-6~{H}-1,6-naphthyridin-2-yl)phenyl]methyl]piperazin-1-yl]phenyl]propanamide (3 entities in total) |
Functional Keywords | akt1, covalent-allosteric, transferase |
Biological source | Homo sapiens |
Total number of polymer chains | 1 |
Total formula weight | 52289.69 |
Authors | Landel, I.,Weisner, J.,Mueller, M.P.,Scheinpflug, R.,Rauh, D. (deposition date: 2018-08-28, release date: 2019-02-20, Last modification date: 2024-01-17) |
Primary citation | Uhlenbrock, N.,Smith, S.,Weisner, J.,Landel, I.,Lindemann, M.,Le, T.A.,Hardick, J.,Gontla, R.,Scheinpflug, R.,Czodrowski, P.,Janning, P.,Depta, L.,Quambusch, L.,Muller, M.P.,Engels, B.,Rauh, D. Structural and chemical insights into the covalent-allosteric inhibition of the protein kinase Akt. Chem Sci, 10:3573-3585, 2019 Cited by PubMed: 30996949DOI: 10.1039/c8sc05212c PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
Download full validation report