6HHF

Crystal Structure of AKT1 in Complex with Covalent-Allosteric AKT Inhibitor Borussertib

Summary for 6HHF

Entry DOI	10.2210/pdb6hhf/pdb
Descriptor	RAC-alpha serine/threonine-protein kinase, Borussertib (3 entities in total)
Functional Keywords	akt1, borussertib, covalent-allosteric, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	52344.73
Authors	Landel, I.,Weisner, J.,Mueller, M.P.,Scheinpflug, R.,Rauh, D. (deposition date: 2018-08-28, release date: 2019-03-20, Last modification date: 2024-01-17)
Primary citation	Weisner, J.,Landel, I.,Reintjes, C.,Uhlenbrock, N.,Trajkovic-Arsic, M.,Dienstbier, N.,Hardick, J.,Ladigan, S.,Lindemann, M.,Smith, S.,Quambusch, L.,Scheinpflug, R.,Depta, L.,Gontla, R.,Unger, A.,Muller, H.,Baumann, M.,Schultz-Fademrecht, C.,Gunther, G.,Maghnouj, A.,Muller, M.P.,Pohl, M.,Teschendorf, C.,Wolters, H.,Viebahn, R.,Tannapfel, A.,Uhl, W.,Hengstler, J.G.,Hahn, S.A.,Siveke, J.T.,Rauh, D. Preclinical Efficacy of Covalent-Allosteric AKT Inhibitor Borussertib in Combination with Trametinib inKRAS-Mutant Pancreatic and Colorectal Cancer. Cancer Res., 79:2367-2378, 2019 Cited by PubMed: 30858154 DOI: 10.1158/0008-5472.CAN-18-2861 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation