6HHJ

Crystal Structure of AKT1 in Complex with Covalent-Allosteric AKT Inhibitor 24b

Summary for 6HHJ

Entry DOI	10.2210/pdb6hhj/pdb
Descriptor	RAC-alpha serine/threonine-protein kinase, ~{N}-[1-methyl-2-oxidanylidene-3-[1-[[4-(5-oxidanylidene-3-phenyl-6~{H}-1,6-naphthyridin-2-yl)phenyl]methyl]piperidin-4-yl]benzimidazol-5-yl]propanamide (3 entities in total)
Functional Keywords	akt1, covalent-allosteric, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	52358.76
Authors	Landel, I.,Weisner, J.,Mueller, M.P.,Scheinpflug, R.,Rauh, D. (deposition date: 2018-08-28, release date: 2019-02-20, Last modification date: 2024-01-17)
Primary citation	Uhlenbrock, N.,Smith, S.,Weisner, J.,Landel, I.,Lindemann, M.,Le, T.A.,Hardick, J.,Gontla, R.,Scheinpflug, R.,Czodrowski, P.,Janning, P.,Depta, L.,Quambusch, L.,Muller, M.P.,Engels, B.,Rauh, D. Structural and chemical insights into the covalent-allosteric inhibition of the protein kinase Akt. Chem Sci, 10:3573-3585, 2019 Cited by PubMed: 30996949 DOI: 10.1039/c8sc05212c PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation