7KR4

Human DNA Ligase 1(E346A/E592A) Bound to a nicked DNA substrate control duplex

Summary for 7KR4

• Entry DOI: 10.2210/pdb7kr4/pdb
• Descriptor: DNA ligase 1, DNA (5'-D(*AP*AP*TP*GP*TP*CP*TP*GP*CP*CP*C)-3'), DNA (5'-D(P*AP*TP*TP*CP*TP*GP*C)-3'), ... (7 entities in total)
• Functional Keywords: dna ligase, dna replication, dna repair, replication fidelity, ligase, ligase-dna complex, ligase/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 83486.84

Authors

Tumbale, P.P.,Williams, R.S. (deposition date: 2020-11-18, release date: 2021-02-03, Last modification date: 2023-10-18)

• Primary citation: Williams, J.S.,Tumbale, P.P.,Arana, M.E.,Rana, J.A.,Williams, R.S.,Kunkel, T.A.; High-fidelity DNA ligation enforces accurate Okazaki fragment maturation during DNA replication.; Nat Commun, 12:482-482, 2021; PubMed: 33473124; DOI: 10.1038/s41467-020-20800-1

Experimental method

X-RAY DIFFRACTION (2.2 Å)